Triboelectric Nanogenerator-Based Self-Powered Urinary Protein Detection Utilizing Triboelectric Material with Colorimetric Function.

Chronic kidney disease (CKD) has a high incidence rate, and if not detected and treated in a timely manner, it poses a risk of progressing to renal failure and even uremia. Performing home monitoring of urinary protein, which is a recognized indicator of CKD, is considered an effective means of achieving early warning for CKD. Although the existing urinary protein test strips for home self-testing are cost-effective and simple, they suffer from drawbacks such as susceptibility to contamination and lack of quantitative detection capability.

Sulforaphane potentiates the efficacy of chemoradiotherapy in glioblastoma by selectively targeting thioredoxin reductase 1.

Chemoradiotherapy is a conventional treatment modality for patients with glioblastoma (GBM). However, the efficacy of this approach is significantly hindered by the development of therapeutic resistance. The thioredoxin system, which plays a crucial role in maintaining redox homeostasis, confers protection to cancer cells against apoptosis induced by chemoradiotherapy.

Angular momentum modulation of vortex Cherenkov radiation in optical waveguides.

Vortex free-electron radiation has attracted considerable interest because of its promising potential for applications in communication, high-density radiation sources, and particle detection. Here, we reveal angular momentum modulation of vortex Cherenkov radiation using subwavelength silicon waveguides. The topological charge of vortex radiation field can be controlled by the position parameters of two electron beams based on the rotational symmetry.

Bamboo-Like Carbon Nanotube-Encapsulated FeC Nanoparticles Activate Confined FeO Nanoclusters Via d-p-d Orbital Coupling for Alkaline Oxygen Evolution Reaction.

The efficient anion exchange membrane water electrolysis is challenging with low cell voltage and long-term stability at large current density, due to the unstable anodic oxygen evolution reaction (OER). Fe-based electrocatalysts are potential candidates for the anodic OER. In Fe-based materials, iron oxides always show better stability in alkaline solution but lower OER activity.

Oxidative reconstructed Ru-based nanoclusters forming heterostructures with lanthanide oxides for acidic water oxidation.

Achieving rapid anodic oxygen evolution reaction (OER) kinetics and improving the stability of the corresponding ruthenium (Ru)-based catalysts is a current priority for the realisation of industrial water splitting. However, the activity and stability of O evolution in electrocatalysis are largely inhibited by the insufficient adsorption of the reactant HO and too strong adsorption of the intermediate OOH*, as well as by the dissolution of the active site due to excessive oxidation. To solve this challenge, herein, we developed a regulatory strategy combining lanthanide oxides and metal oxidative reconfiguration.

End-to-End Implicit Object Pose Estimation.

To accurately estimate the 6D pose of objects, most methods employ a two-stage algorithm. While such two-stage algorithms achieve high accuracy, they are often slow. Additionally, many approaches utilize encoding-decoding to obtain the 6D pose, with many employing bilinear sampling for decoding.

Enhancing hospice care with psychological support and a nomogram to predict delirium in patients with advanced solid tumors.

To assesses the impact of integrating hospice care with psychological interventions on patient well-being and to introduce a predictive nomogram model for delirium that incorporates clinical and psychosocial variables, thereby improving the accuracy in hospice care environments. Data from 381 patients treated from September 2018 to February 2023 were analyzed. The patients were divided into a control group (n=177, receiving standard care) and an experimental group (n=204, receiving combined hospice care and psychological interventions) according to the treatment modality.

Bioinspired Robust Gas-Permeable On-Skin Electronics: Armor-Designed Nanoporous Flash Graphene Assembly Enhancing Mechanical Resilience.

Soft on-skin electrodes play an important role in wearable technologies, requiring attributes such as wearing comfort, high conductivity, and gas permeability. However, conventional fabrication methods often compromise simplicity, cost-effectiveness, or mechanical resilience. In this study, a mechanically robust and gas-permeable on-skin electrode is presented that incorporates Flash Graphene (FG) integrated with a bioinspired armor design.

A Self-Powered Biochemical Sensor for Intelligent Agriculture Enabled by Signal Enhanced Triboelectric Nanogenerator.

Precise agriculture based on intelligent agriculture plays a significant role in sustainable development. The agricultural Internet of Things (IoTs) is a crucial foundation for intelligent agriculture. However, the development of agricultural IoTs has led to exponential growth in various sensors, posing a major challenge in achieving long-term stable power supply for these distributed sensors.

Polarized vortex Smith-Purcell radiation with cascaded metasurfaces.

We introduce the concept of polarized vortex Smith-Purcell radiation by the interaction of an electron beam and cascaded metasurfaces. The spin and orbital angular momenta of Smith-Purcell radiation are determined by the cascaded metasurface that consists of a grating and a phase gradient metasurface. The grating converts the electron beam radiation into the desired polarized light, while the phase gradient metasurface generates the vortex light.

Knocking out FAM20C in pre-osteoblasts leads to up-regulation of osteoclast differentiation to affect long bone development.

Family with sequence similarity 20 member C (FAM20C) is a Golgi casein kinase that phosphorylates extracellularly-secreted regulatory proteins involved in bone development and mineralization, but its specific role in bone development is still largely unknown. In this study, to examine the specific mechanisms that FAM20C influences bone development, we cross-bred Osx-Cre with FAM20C mice to establish a Osx-Cre; FAM20C knockout (oKO) mouse model; FAM20C was KO in pre-osteoblasts. oKO development was examined at 1-10 weeks, in which compared to control FAM20C, they had lower body weights and bone tissue mineralization.

Using formalin fixed paraffin embedded tissue to characterize the microbiota in p16-positive and p16-negative tongue squamous cell carcinoma: a pilot study.

Background: Tongue squamous cell carcinoma (TSCC) is the most common oral cavity cancer, and p16 immunohistochemistry is an exact and available tool in the prognostic and predictive characterization of squamous cell cancers in the head and neck. Microorganisms have a close relationship with the development of TSCC. However, the association between oral bacteria and p16 status has not been well defined in the case of TSCC.

Monometallic Ultrasmall Nanocatalysts via Different Valence Atomic Interfaces Boost Hydrogen Evolution Catalysis.

Synergistic monometallic nanocatalysts have attracted much attention due to their high intrinsic activity properties. However, current synergistic monometallic nanocatalysts tend to suffer from long reaction paths due to restricted nanoscale interfaces. In this paper, we synthesized the interstitial compound N-Pt/CNT with monometallic atomic interfaces.

Epithelial-specific deletion of FAM20A leads to short root defects.

Short Root Defects defined by a reduced ratio of root to crown, may culminate in root resorption and subsequent tooth loss, in spite of the absence of apparent symptoms. Such defects present considerable impediments to orthodontic treatment and restoration. Recent identification of Fam20a, an emergent pseudokinase, has been associated with enamel development and tooth eruption, yet its definitive role in root formation and eruption remains ambiguous.

Nursing model based on Snyder's hope theory in emergency care of patients with acute myocardial infarction.

Objective: To investigate the effect of Snyder's hope theory in emergency care for patients with acute myocardial infarction (AMI).

Methods: This retrospective study included 200 AMI patients admitted to Rugao People's Hospital from January 2019 to December 2021. The patients were divided into a conventional group (routine care, n=100) and an intervention group (care based on Snyder's Hope theory, n=100) according to differences in nursing approach.

RNautophagic regulation of DNMT3a-dependent DNA methylation by Linc00942 enhances chemoresistance in gastric cancer.

Background: Energy balance has long been known to extend lifespans and inhibit carcinogenesis in multiple species by slowing age-related epigenetic changes while the underlying mechanisms remain largely unknown. Herein, we found that starvation activated autophagy to remodel the DNA methylation profile by inhibiting DNMT3a expression.

Methods: Illumina Infinium MethylationEPIC BeadChip and dot blot assay were performed to quantify the global DNA methylation level.