Synergistic Effects Between Mixed Plastics and Their Impact on Pyrolysis Behavior and Pyrolysis Products.

Pyrolysis is recognized as a promising technology for waste plastics management. Although there have been many studies on pyrolysis of waste plastics, there is still a lack of in-depth research on the mechanism of synergistic effect between mixed plastics and the mechanism of product formation. In this paper, based on the pyrolysis characteristics of Polystyrene, Polyethylene, and mixed plastics (Polystyrene/Polyethylene), it is demonstrated that a synergistic effect exists in the co-pyrolysis of Polystyrene/Polyethylene and affects the pyrolysis behavior and pyrolysis products.

Serum miR-155-5p assists the diagnostic sensitivity and accuracy of low-dose spiral CT imaging in early lung cancer.

Background: Low-dose spiral CT imaging has been employed for cancer diagnosis, but its sensitivity and specificity were unsatisfactory. MicroRNAs have been considered an approach for screening cancers, and the function of miR-155-5p in lung cancer has been previously revealed.

Objectives: This study assessed the diagnostic value of combining low-dose spiral CT with serum miR-155-5p in lung cancer aiming to explore a novel strategy to assist the clinical cancer diagnosis.

Activating Esterase D by PFD5 exerts antiviral effect through inhibiting glutathionization of LAMP1 during Senecavirus A infection.

Seneca virus A (SVA) is a newly discovered small nucleic acid virus, which can cause swine blister disease (PVD). Currently, there is no drug or vaccine. Studies have shown that SVA relies on the endolysosomal pathway to accomplish intracellular transport and release, and can disrupt lysosomal homeostasis, but its specific mechanism has not been revealed.

Consumption of Total and Specific Alcoholic Beverages and Long-Term Risk of Gout Among Men and Women.

Importance: Previous studies on alcohol consumption and incident gout have mostly included men or combined both sexes, and the sex-specific associations between alcohol consumption and gout are poorly understood.

Objective: To evaluate the consumption of total and specific alcoholic beverages in association with incident gout in men and women.

Design, Setting, And Participants: This prospective cohort study included 401 128 participants in the UK Biobank aged 37 to 73 years who were free of gout at baseline (2006-2010).

Adduct of Pesticide and Lignocellulosic Waste via Cleavable Silaketal Linkages for Agricultural Double Reduction.

The abuse of hazardous agrochemicals leads to excessive toxic agricultural emissions, posing a tremendous threat to the natural surroundings and human well-being. In practice, the amount of pesticides in protecting crops is often far less than that lost into the environment through evaporation and leaching. Minimizing the use of pesticides as well as improving their use efficiency has been included in the policy of "agricultural double reduction," besides replacing the chemical fertilizer with straw returning.

Piezoelectric-based large-angle stroke fast steering mirror with high ratio of output range to resolution and self-sensing capability.

In space optical applications, the piezoelectric-actuated fast steering mirror (FSM) is one of the pivotal components for high-precision beam capturing and trajectory tracking. The FSM is restrained in small-angle scanning applications due to the short actuation stroke of the incorporated piezoelectric materials. This study introduces a dual-axis sub-radian stroke FSM with a high ratio of output range to resolution and self-sensing capability, based on cascading structures for displacement amplification and flexible parts for feedback.

Female reproductive factors, exogenous hormone use, and incident chronic kidney disease and end-stage renal disease.

Context: Younger women have a slower progressive loss of kidney function than age-matched men and the sex advantage diminishes after menopause, suggesting a role for female hormones in the development of kidney diseases.

Objective: To examine the relationships of numerous reproductive factors and exogenous hormone use with long-term risk of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in women.

Methods: A total of 260,108 women without prevalent CKD and ESRD were included.

Expression of RIPK1 and FADD are associated with chemosensitivity and survival in head and heck squamous cell carcinoma via tanshinone IIA-mediated modulation of the RIPK1-FADD-Caspase 8 complex.

Tanshinone IIA (Tan IIA), a main active ingredient of salvia miltiorrhiza, has a wide range of antitumor effects, while its specific role and mechanism in head and neck squamous cell carcinomas (HNSCC) is not fully understood. Totally 59 primary HNSCC patients underwent two courses of induction chemotherapy before surgery. The association between expression of Fas-Associated Death Domain (FADD) and receptor interacting protein kinase 1 (RIPK1) and chemotherapy resistance and survival were evaluated.

Crosstalk between T lymphocyte and extracellular matrix in tumor microenvironment.

The extracellular matrix (ECM) is a complex three-dimensional structure composed of proteins, glycans, and proteoglycans, constituting a critical component of the tumor microenvironment. Complex interactions among immune cells, extracellular matrix, and tumor cells promote tumor development and metastasis, consequently influencing therapeutic efficacy. Hence, elucidating these interaction mechanisms is pivotal for precision cancer therapy.

CircSNX6 promotes proliferation, metastasis, and angiogenesis in hepatocellular carcinoma via miR-383-5p/VEGFA signaling pathway.

The role of circular RNA (circRNAs) in hepatocellular carcinoma (HCC) has been extensively studied. Previous research has highlighted the regulatory role of circSNX6 in HCC cells and tissues. However, the precise mechanism underlying HCC progression still requires comprehensive investigation.

Microvascular burden and long-term risk of stroke and dementia in type 2 diabetes mellitus.

Objective: To examine the associations between microvascular disease (MVD) and risk of stroke, dementia, and their major subtypes among individuals with type 2 diabetes mellitus (T2DM).

Methods: We included 26,173 participants with T2DM from the UK Biobank who had no known stroke or dementia at baseline. MVD burden was reflected by the presence of retinopathy, peripheral neuropathy, and chronic kidney disease.

Revealing the Mechanism of Ink Flaking from Surfaces of Palm Leaves ().

Palm leaves are the primary literary support in South and Southeast Asia before the widespread use of paper. However, palm leaf manuscripts face the threat of information loss due to the persistent issue of ink flaking during long-term preservation. Herein, we focus on studying the botanical structure, surface properties, and surface composition of palm leaves to gain an insightful understanding of the mechanism of ink flaking.

Glutathione supplementation improves fat graft survival by inhibiting ferroptosis via the SLC7A11/GPX4 axis.

Background: Autologous fat grafting is hampered by unpredictable graft survival, which is potentially regulated by ferroptosis. Glutathione (GSH), a powerful antioxidant used in tissue preservation, has ferroptosis-regulating activity; however, its effects on fat grafts are unclear. This study investigated the effects and mechanisms of GSH in fat graft survival.

Cyanide removal of gold cyanide residues by manganese compounds as new decyanation reagents.

Plenty of the toxic gold cyanide residues are produced by cyanidation process of gold extraction. As a kind of hazardous solid wastes, cyanide residues must be treated to remove cyanide before disposal. In this study, the removal of cyanide in gold cyanide residues by manganese compounds (KMnO and MnO) was investigated.

Association of phthalate exposure with all-cause mortality across renal function status: The U.S. National Health and Nutrition Examination Survey, 2005-2018.

Background: Wide phthalate exposure has been associated with both declines in renal function and an elevated risk of mortality. Whether phthalate-associated risk of premature mortality differs by renal function status remains unclear.

Methods: This study included 9605 adults from the U.

IGF2 is upregulated by its antisense RNA to potentiate pancreatic cancer progression.

Pancreatic cancer is a deadly cancer. More and more long noncoding RNAs (lncRNAs) have received confirmation to be dysregulated in tumors and exert the regulatory function. Studies have suggested that lncRNA insulin-like growth factor 2 antisense RNA (IGF2-AS) participates in the development of some cancers.

Characteristics of FXa-storing platelets in hemophilia B mice and the influence of alcohol on the platelets.

Platelet-stored activated blood coagulation factor X (FXa) has great potential in the gene therapy of hemophilia B (HB). However, we still need to understand more about the properties of FXa-storing platelets and how dietary factors affect them. We created transgenic mice called 2bFXa-HB, which had stable expression and storage of FXa in their platelets, resulting in the alleviation of the bleeding disorder in these mice.

Coffee Consumption and Incidence of Cardiovascular and Microvascular Diseases in Never-Smoking Adults with Type 2 Diabetes Mellitus.

The relationship between coffee consumption and diabetes-related vascular complications remains unclear. To eliminate confounding by smoking, this study assessed the relationships of coffee consumption with major cardiovascular disease (CVD) and microvascular disease (MVD) in never-smokers with type 2 diabetes mellitus (T2DM). Included were 9964 never-smokers with T2DM from the UK Biobank without known CVD or cancer at baseline (7781 were free of MVD).

Progress in the mechanism of autophagy and traditional Chinese medicine herb involved in alcohol-related liver disease.

Alcohol-related liver disease (ALD) is chronic liver damage caused by long-term heavy drinking with, extremely complicated pathogenesis. The current studies speculated that excessive alcohol and its metabolites are the major causes of liver cell toxicity. Autophagy is evolutionarily conserved in eukaryotes and aggravates alcoholic liver damage, through various mechanisms, such as cellular oxidative stress, inflammation, mitochondrial damage and lipid metabolism disorders.

Interactive effect between sleep and exercise on depressive symptoms in Chinese adolescents.

Objectives: The study aimed to investigate the effects of sleep and exercise, individually and jointly, on depressive symptoms in Chinese adolescents.

Methods: Cluster sampling was used to conduct a cross-sectional, electronic survey among 11,563 students from five primary and high schools in Sichuan Province in Western China. The questionnaire contained custom-designed items concerning sleep and exercise, while it used the Center for Epidemiologic Studies Depression Scale to assess depressive symptoms and the Core Self-Evaluations Scale to assess core self-evaluation.

CDCA7 serves as a novel prognostic marker in human hepatocellular carcinoma.

c-Myc oncogene plays an important role in tumorigenesis, cell division cycle associated 7 (CDCA7), recently found that it is a direct target gene of c-Myc, is upregulated in many tumors, but its role in tumor progression is still poorly understood. CDCA7 expression and prognosis were analyzed in hepatocellular carcinoma using TIMER2.0 and Kaplan-Meier databases, while genomic changes were studied using cbioportal.