Publications by authors named "WenTao Ye"

Article Synopsis
  • Microcystin-LR (MC-LR) and microplastics (MPs) are emerging pollutants in freshwater aquaculture that can affect nitrogen cycles and microbial communities.
  • This study explored the effects of traditional (polystyrene) and biodegradable (polylactic acid) microplastics when co-exposed with MC-LR in simulated aquaculture environments.
  • Results indicated that combined pollution significantly disrupted nitrogen transformation processes and altered microbial community dynamics, with the combination of polystyrene and MC-LR presenting the highest risk.
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Electrochemical hydrogenation of aldehyde molecules, exemplified by 5-hydroxymethylfurfural (HMF), offers a sustainable approach for synthesizing higher value-added alcohols. However, severe coupling side reactions impede its practical implementation at high concentrations. In this work, a cluster-level heterostructure of a PMo/Cu catalyst is synthesized by loading Keggin-type phosphomolybdic acid (HPMoO, PMo) onto Cu nanowires.

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Background: Liquid biopsies, for example, exosomal circular RNA (circRNA) can be used to assess potential predictive markers for hepatocellular carcinoma (HCC) in patients after curative resection. This study aimed to search for effective prognostic biomarkers for HCC in patients after surgical resection based on exosomal circRNA expression profiles. We developed two nomograms incorporating circRNAs to predict the postoperative recurrence-free survival (RFS) and overall survival (OS) of HCC patients.

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Hepatocellular carcinoma (HCC) is associated with a highly heterogeneous immune environment that produces an immune response to various locoregional treatments (LRTs), which in turn affects the effectiveness of immunotherapy. Although LRTs still dominate HCC therapies, 50-60% of patients will ultimately be treated with systemic therapies and might receive those treatments for the rest of their life. TACE, SIRT, and thermal ablation can dramatically increase the immunosuppressive state of HCC, a condition that can be addressed by combination with immunotherapy to restore the activity of lymphocytes and the secretion of cellular immune factors.

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A variety of malignancies preferentially meet energy demands through the glycolytic pathway. Hypoxia‑induced cancer cell adaptations are essential for tumor development. However, in cancerous glycolysis, the functional importance and underlying molecular mechanism of prolyl hydroxylase domain protein 2 (PHD2) have not been fully elucidated.

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Background: Exploring the association of diet and indoor and outdoor environments on the gut microbiome of red-crowned cranes. We investigated the microbiome profile of the 24 fecal samples collected from nine cranes from day 1 to 35. Differences in the gut microbiome composition were compared across diet and environments.

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Background: Efforts to precisely assess tumor-specific T-cell immune responses still face major challenges, and the potential molecular mechanisms mediating hepatocellular carcinoma (HCC) microenvironment imbalance after incomplete radiofrequency ablation (iRFA) are unclear. This study aimed to provide further insight into the integrated transcriptomic and proteogenomic landscape and identify a new target involved in HCC progression following iRFA.

Methods: Peripheral blood and matched tissue samples were collected from 10 RFA-treated HCC patients.

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Background: The combined immunotargeting therapy of hepatocellular carcinoma (HCC) have brought remarkable results. There are still some drawbacks to the application of the immune-modified Response Evaluation Criteria in Solid Tumors to Immunotherapy (imRECIST). How many weeks does it take to confirm the true disease progression for HCC patients who had reported disease progression for the first time based on imRECIST.

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Hepatic stellate cells (HSCs) play an essential role in various liver diseases, and exosomes are critical mediators of intercellular communication in local and distant microenvironments. Cellular crosstalk between HSCs and surrounding multiple tissue-resident cells promotes or inhibits the activation of HSCs. Substantial evidence has revealed that HSC-derived exosomes are involved in the occurrence and development of liver diseases through the regulation of retinoid metabolism, lipid metabolism, glucose metabolism, protein metabolism, and mitochondrial metabolism.

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Article Synopsis
  • Chlorantraniliprole (CAP) is an agricultural pesticide that can negatively impact silkworm (Bombyx mori) cocoon formation, prompting the need for better toxicity assessment methods.
  • The study found that exposure to low concentrations of CAP decreases key ATPase activities in silkworms and significantly affects the regulation of AMPK-related and autophagy-related genes.
  • Overall, the findings highlight that CAP exposure causes autophagy in the silk glands of silkworms, impairing their physiological functions and aiding in evaluating the toxicity of environmental pesticide residues.
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Here, we develop a simple, efficient, bacmid-based, selection marker-free method for gene deletion and editing in baculovirus genomes. Specifically, based on pFastbac1, a donor plasmid with long left and right homology arms but without a reporter was constructed for disrupting ie1, an essential baculovirus gene. Instead of ligating with a plasmid, the homology arms were introduced to the polyhedrin locus of BmNPV bacmid using the BmNPV bac-to-bac expression system.

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The intensive application of chlorantraniliprole (CAP) leaves residues in the environment, posing a potential threat to non-target organisms. In the present study, we investigated the adverse effects of sublethal CAP exposure on Bombyx mori. Sublethal CAP (0.

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Hepatocellular carcinoma (HCC) remains a health challenge with increasing incidence worldwide. Radiofrequency ablation (RFA) is a potentially curative option for patients with early-stage HCC. However, the high rate of tumor recurrence limits long-term survival when the tumors are larger than 2 cm and undergoing insufficient RFA (iRFA).

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Recently, the emerging role of circular RNAs (circRNAs) in tumor development and progression has been a topic of great interest. Nevertheless, the effects of hepatic stellate cell (HSC)-derived exosomes in hepatocellular carcinoma (HCC) remain unclear. Here, we aim to explore the potential effect of HSC exosome-derived circWDR25 on the aggressiveness of HCC.

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Gut microbiota homeostasis is important for host health and well-being; however, drugs may affect the composition and function of the gut microbiota. Red-crowned cranes are a vulnerable species. Treatment of red-crowned cranes with avian influenza vaccines and anthelmintics has played pivotal roles in therapeutic management in zoos.

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The Tachinidae are natural enemies of many lepidopteran and coleopteran pests of crops, forests, and fruits. However, host-tachinid parasitoid interactions have been largely unexplored. In this study, we investigated the effects of tachinids on host biological traits, using , a generalist parasitoid, and the silkworm , its lepidopteran host, as models.

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A representative silkworm rearing mode of Ⅰ-Ⅲ instars reared on artificial diet and Ⅳ-Ⅴ instars reared on fresh mulberry leaves has been recognized in some sericultural areas of China. Under this rearing mode, silkworms are prone to be poisoned by pesticide residues on mulberry leaves at the Ⅳ and Ⅴ instar stages. As one of the most widely applied insecticides, λ-cyhalothrin was used to study the insecticide tolerance of silkworm reared on artificial diet (referred as the AD group).

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The red-crowned crane (Grus japonensis) is an endangered species distributed across southeast Russia, northeast China, Korea, and Japan. Here, we sequenced for the first time the full-length unreferenced transcriptome of red-crowned crane mixed samples using a PacBio Sequel platform. A total of 359,136 circular consensus sequences (CCS) were obtained via clustering to remove redundancy.

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The neonicotinoid insecticide acetamiprid is widely applied for pest control in agriculture production, and its exposure often results in adverse effects on a non-target insect, Bombyx mori. However, only few studies have investigated the effects of exposure to sublethal doses of neonicotinoid insecticides on gut microbiota and susceptibility to pathogenic bacteria. In this study, we aimed to explore the possible mechanisms underlying the acetamiprid-induced compositional changes in gut microbiota of silkworm and reduced host resistance against detrimental microbes.

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Silkworm (Bombyx mori) is an important economic insect and an attractive model system. A series of autophagy-related genes (Atgs) are involved in the autophagic process, and these Atgs have been proved to play important roles in the development. Atg7 stands at the hub of two ubiquitin-like systems involving Atg8 and Atg12 in the autophagic vesicle.

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Members of the genus (Columbidae) are widely distributed in southern Asia and the Indo-Malayan Region but their relationships are poorly understood. Better knowledge of the systematic status of this genus may help studies of historical biogeography and taxonomy. The complete mitochondrial genome of was characterized, a first for the genus.

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Article Synopsis
  • TiO nanoparticles (TiO NPs) are commonly used in various industries but pose environmental health risks due to their persistence, prompting concerns about their safety.* -
  • A study using the ovarian cell line from the silkworm Bombyx mori found that exposure to TiO NPs negatively affected cell viability, especially at concentrations over 20 mg/L.* -
  • The research revealed that TiO NPs exposure led to oxidative stress, DNA damage, and inflammatory responses by reducing antioxidant gene expression and increasing pro-inflammatory signaling pathways.*
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Article Synopsis
  • * Silkworms exposed to acetamiprid showed reduced silk gland index and cocooning rates, with gene expression analysis revealing significant oxidative stress and up-regulation of antioxidant enzymes in their posterior silk glands.
  • * The study highlights the up-regulation of key genes in the FoxO/CncC/Keap1 signaling pathway, indicating that the oxidative stress from acetamiprid exposure may be responsible for the cocooning disorder in silkworms, providing
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The accurate prediction of storm surge disasters' direct economic losses plays a positive role in providing critical support for disaster prevention decision-making and management. Previous researches on storm surge disaster loss assessment did not pay much attention to the overfitting phenomenon caused by the data scarcity and the excessive model complexity. To solve these problems, this paper puts forward a new evaluation system for forecasting the regional direct economic loss of storm surge disasters, consisting of three parts.

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This study aimed to explore the toxicity of environmental residues of graphene oxide nanoparticles (GONPs) to reproduction of Lepidopteron insects using both ovary cell line (BmN) and individual female Bombyx mori as the research subjects. The results showed that GONPs dose dependently affect BmN cells. At higher concentrations (>25 mg/L), GONPs led to oxidative stress, ROS accumulation and DNA damage in BmN cells and significantly reduced their survival rate (p ≤ 0.

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Synopsis of recent research by authors named "WenTao Ye"

  • - Wentao Ye's research focuses on the environmental impacts of pollutants, particularly the interactions between cyanotoxins and microplastics in aquaculture systems, as well as their effects on nitrogen transformation and microbial communities.
  • - In the field of cancer research, Ye has developed prognostic nomograms based on exosomal circRNA and studied the immune responses of hepatocellular carcinoma (HCC) to various treatments, seeking to improve therapeutic strategies and patient outcomes.
  • - His studies also investigate metabolic pathways in different cancers, specifically the role of prolyl hydroxylase 2 in colorectal cancer and the effects of hepatic stellate cell-derived exosomes in liver diseases, indicating a strong commitment to understanding disease mechanisms and potential treatment targets.

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