An Optimized Bidirectional Long Short-Term Memory Model Based on Hyperspectral Analysis of Protein Content in Milk Powder.

Protein content is an important index in the assessment of dairy nutrition. As a crucial source of protein absorption in people's daily life, the quality of milk powder products not only has a deep impact on the development of the dairy industry, but also seriously damages the health of consumers. It is of great significance to find a faster and more accurate method for detecting milk protein content.

Sex Differences in the Association Between Cardiovascular Autonomic Neuropathy and Mortality in Patients With Type 2 Diabetes: The ACCORD Study.

Background: Cardiovascular autonomic neuropathy (CAN) is a severe complication of type 2 diabetes. Significant sex-related differences have been observed in type 2 diabetes consequences such as mortality. However, the effect of sex on the association between CAN and mortality in patients with type 2 diabetes is currently unknown.

Correction: Reconstructing the phase of vanadium oxides enables redox-catalysis manipulated reversible sulfur conversion for stable Zn-S batteries.

[This corrects the article DOI: 10.1039/D4SC06593J.].

Functions of Insulin-like Peptide Genes ( and ) in Female Reproduction of the Predatory Ladybird (Coleoptera: Coccinellidae).

Insulin-like peptides (ILPs) are important peptide hormones in insects, particularly involved in regulating physiological processes such as growth, development, and reproduction. However, the specific roles of ILPs in the reproduction of natural enemy insects remain unknown. In this study, two ILP genes, and , were cloned and their functions were analyzed in female L.

Knockout or inhibition of DHPS suppresses ovarian tumor growth and metastasis by attenuating the TGFβ pathway.

Deoxyhypusine synthase (DHPS) is an enzyme encoded by the DHPS gene, with high expression in various cancers, including ovarian cancer (OC). DHPS regulates the translation initiation factor EIF5A, and EIF5A2 knockout inhibits OC tumor growth and metastasis by blocking the epithelial-to-mesenchymal transition (EMT) and the TGFβ pathway. In this study, we show that DHPS is amplified in OC patients, and its elevated expression correlates with poor survival.

Prognostic value of the derived inflammatory marker SIRI in postmenopausal women with coronary artery disease.

Objective: The aim of this study was to explore the predictive value of the Systemic Inflammatory Response Index (SIRI) for the prognosis of older postmenopausal women with coronary artery disease (CAD).

Patients And Methods: This retrospective cohort study included 617 postmenopausal female patients aged 50 years or older with a CAD diagnosis confirmed by coronary angiography seen at the First Affiliated Hospital of Zhengzhou University from January 2019 to December 2020. Patients were divided into three groups based on SIRI tertiles.

Advanced Catalysts for the Chemical Recycling of Plastic Waste.

Plastic products bring convenience to various aspects of the daily lives due to their lightweight, durability and versatility, but the massive accumulation of post-consumer plastic waste is posing significant environmental challenges. Catalytic methods can effectively convert plastic waste into value-added feedstocks, with catalysts playing an important role in regulating the yield and selectivity of products. This review explores the latest advancements in advanced catalysts applied in thermal catalysis, microwave-assisted catalysis, photocatalysis, electrocatalysis, and enzymatic catalysis reaction systems for the chemical recycling of plastic waste into valuable feedstocks.

MiR-675 Inhibits Primary Ovarian Tumor Growth and Metastasis by Suppressing EMT and TGFβ Signaling.

MicroRNAs (miRNAs) can function as either tumor suppressors or oncogenes. This study explores the role of miR-675 in ovarian cancer (OC) using OC cell lines and an orthotopic mouse model. We demonstrate that miR-675 expression inhibits primary tumor growth and metastasis by targeting TGFβ1, suppressing epithelial to mesenchymal transition (EMT), and attenuating the TGFβ signaling pathway.

Dynamic transcriptomics unveils parallel transcriptional regulation in artemisinin and phenylpropanoid biosynthesis pathways under cold stress in Artemisia annua.

Cold stress, a major abiotic factor, positively modulates the synthesis of artemisinin in Artemisia annua and influences the biosynthesis of other secondary metabolites. To elucidate the changes in the synthesis of secondary metabolites under low-temperature conditions, we conducted dynamic transcriptomic and metabolite quantification analyses of A. annua leaves.

The antitumor mechanisms of glabridin and drug delivery strategies for enhancing its bioavailability.

Glabridin, a flavonoid derived from the plant , has garnered significant attention due to its diverse pharmacological effects, including antioxidant, antibacterial, anti-inflammatory, hypolipidemic, and hypoglycemic activities. Studies have shown that glabridin exhibits substantial antitumor activity by modulating the proliferation, apoptosis, metastasis, and invasion of cancer cells through the targeting of various signaling pathways, thus indicating its potential as a therapeutic agent for malignant tumors. To enhance its solubility, stability, and bioavailability, several drug delivery systems have been developed, including liposomes, cyclodextrin inclusion complexes, nanoparticles, and polymeric micelles.

Clinical Insights into Neurosyphilis Patients with Leptomeningeal Enhancement of Spinal Cord.

Background And Objectives: This study aims to report the clinical, biological, and imaging features of cross-sectional study of neurosyphilis patients with leptomeningeal enhancement of spinal cord. Here, 51 neurosyphilis patients with leptomeningeal enhancement of spinal cord positivity are described, offering a promise in terms of early diagnosis, thereby enabling timely detection and treatment.

Methods: We retrospectively included all neurosyphilis patients enrolled in this study from December 2019 to January 2024.

The Relationship Between Family Communication and Adolescent Problematic Internet Use: The Chain Mediation Effects of Loneliness and Depression.

Introduction: Problematic internet use (PIU) is a significant issue during adolescence. It is recognized as a condition for further study in the DSM-5 and may also be a consequence of underlying psychopathologies, as suggested by previous studies. Poor family communication is an important predictor of adolescent PIU.

Risk of intraoperative hemorrhage during cesarean scar ectopic pregnancy surgery: development and validation of an interpretable machine learning prediction model.

Background: Current models for predicting intraoperative hemorrhage in cesarean scar ectopic pregnancy (CSEP) are constrained by known risk factors and conventional statistical methods. Our objective is to develop an interpretable prediction model using machine learning (ML) techniques to assess the risk of intraoperative hemorrhage during CSEP in women, followed by external validation and clinical application.

Methods: This multicenter retrospective study utilized electronic medical record (EMR) data from four tertiary medical institutions.

Deciphering structure-rheological properties relationship via the studies of 11 s-rich and 7 s-rich soy protein isolate.

Rheological properties influence the velocity gradient in the die passage of the extruder and the formation of fibrous structure of plant protein. The rheological properties of 11 s-rich (11 s-RI) and 7 s-rich (7 s-RI) soy protein fractions prepared at a pilot scale were studied to explore their potential in the production of extruded textured proteins. The results showed that compared to 7 s-RI, 11 s-RI exhibited larger particle sizes, lower solubility, lower water holding capacity of insoluble protein, and lower net surface charge in aqueous solutions.

The feature enhancement method of artistic images based on histogram equalization and bilateral filtering.

To improve the rendering effect of artistic images, a method enhancing features of artistic images is proposed based on histogram equalization and bilateral filtering in the article. Firstly, artistic images are divided into both high and low-frequency representations, and the multi-step enhancement processing level is delimited by multi-band decomposition. Secondly, the noise in the image is removed by bilateral filtering.

Associations of combined accelerated biological aging and genetic susceptibility with incidence of heart failure in a population-based cohort study.

The global aging population raises concerns about heart failure (HF), yet its association with accelerated biological age (BA) remains inadequately understood. We aimed to examine the longitudinal association between BA acceleration and incident HF risk, assess its modifying effect on genetic susceptibility, and how much BA acceleration mediates the impact of modifiable health behaviors on incident HF. We analyzed 274,608 UK Biobank participants without HF at baseline.

Enhanced Enantioselective Sensing of 1,1'-Bi-2-naphthol and Mandelic Acid by Proportional Fluorescence Sensor 3DOM Zn-MOF-74-l-Trp with Hierarchical Macro-Micropore Structure.

The enantioselective performance of porous chiral metal-organic frameworks (CMOFs) is closely related to the pore size and uniformity of easily accessible active sites. The chiral recognition efficiency of microporous CMOFs is hindered by the restricted diffusion of the guest. Hierarchical porous chiral CMOFs with multiple pore size regimes ranging from micropores to macropores have emerged as potential candidates in chiral separation applications.

Ultrastretchable and highly sensitive ionic conductive hydrogel for environmentally resistant all-in-one human-motion sensors.

Conductive hydrogels have been considered ideal candidate materials for fabricating human-motion sensors due to their combination properties of electronic and tissue-like soft nature and the similar functions of human skin with mechanical and sensory properties. However, the perfect integration of multiple functionalities such as environmentally tolerant, stretchable, self-adhesive, self-healing, transparent, high sensitivity, and rapid response in one system (all-in-one) is still a significant challenge. Herein, a novel ionic conductive hydrogel platform with excellent comprehensive performance through multiple dynamic interactions was prepared by employing [BMIm]BF/glycerol/water ternary solvent system.