Is it possible to foot reflexology for infants with sensorineural hearing loss?

Foot reflexology is a non-invasive and safe complementary therapy that works by massaging the reflex zones of the feet and exerts systemic or whole-body regulation through meridian nerve conduction. This therapy is commonly used in the treatment of various conditions such as autism and Parkinson's disease. However, there is limited reporting on the use of foot reflexology therapy for infants with sensorineural hearing loss (SNHL).

Ultrastable Imidazole-linked Porous Organic Cages for Ammonia Capture and Detection.

Here, we report the facile synthesis of imidazole-linked porous organic cages (IPOCs) via an in situ cyclization reaction protocol. Specifically, three IPOCs with [2+4] lantern-like structures and one with a [3+6] triangular prism structure were successfully prepared through condensation reactions between tetraformyl-functionalized calix[4]arene and bis(o-phenylenediamine) monomers in a single pot. Notably, these IPOCs exhibit high porosity, with Brunauer-Emmett-Teller (BET) specific surface areas reaching up to 1162 m g.

Metal-Organic Framework with Open Metal Sites for D/H Separation.

The separation of hydrogen isotopes remains a significant challenge due to their nearly identical physicochemical properties. Recently, metal-organic frameworks employing the chemical affinity quantum sieving effect have garnered increasing attention for hydrogen isotope separation. In this study, with open metal sites was synthesized and demonstrated high hydrogen isotope adsorption capacities of 266 cm/g for H and 288 cm/g for D.

Maize Kernel Broken Rate Prediction Using Machine Vision and Machine Learning Algorithms.

Rapid online detection of broken rate can effectively guide maize harvest with minimal damage to prevent kernel fungal damage. The broken rate prediction model based on machine vision and machine learning algorithms is proposed in this manuscript. A new dataset of high moisture content maize kernel phenotypic features was constructed by extracting seven features (geometric and shape features).

Transcription factor CaPHR3 enhances phosphate starvation tolerance by up-regulating the expression of the CaPHT1;4 phosphate transporter gene in pepper.

Plants frequently encounter phosphate (Pi) starvation due to its scarce availability in soil, necessitating an adaptive phosphate starvation response (PSR). This study explores this adaptation in pepper (Capsicum annuum L.) under low-Pi stress, focusing on the PHOSPHATE STARVATION RESPONSE (PHR) gene family.

Plant extracellular vesicles contribute to the amplification of immune signals during systemic acquired resistance.

Plant extracellular vesicles play a role in systemic acquired resistance by facilitating the transmission of immune signals between plant cells. Extracellular vesicles (EVs) play a critical role in facilitating the transfer of nucleic acids and proteins between plants and pathogens. However, the involvement of plant EVs in intercellular communication and their contribution to the regulation of physiological and pathological conditions in plants remains unclear.

Hydrophilic Ethylene Glycol Fragments: A Determinant Affecting the Therapeutic Index of Paclitaxel Prodrug Nanoassemblies.

Prodrug-based nanoassemblies are promising platforms for cancer therapy. Prodrugs typically consist of three main components: drug modules, intelligent response modules, and modification modules. However, the available modification modules are usually hydrophobic aliphatic side chains, which affect the activation efficiency of the prodrugs.

The Prevalence of Low-level Viraemia and Its Association with Virological Failure in People Living With HIV: A Systematic Review and Meta-Analysis.

Low-level viraemia (LLV) following antiretroviral therapy (ART) in people living with HIV (PLWH) has not received sufficient attention. To the determine the prevalence of LLV and its association with virological failure (VF), we systematically reviewed evidence-based interventions for PLWH. We searched PubMed, the Cochrane Library, Embase, and Web of Science from inception to 22 May 2024.

Platelet Membrane-Coated HGF-PLGA Nanoparticles Promote Therapeutic Angiogenesis and Tissue Perfusion Recovery in Ischemic Hindlimbs.

Therapeutic angiogenesis has garnered significant attention as a potential treatment strategy for lower limb ischemic diseases. Although hepatocyte growth factor (HGF) has been identified as a key promoter of therapeutic angiogenesis, its clinical application is limited due to its short half-life. In this study, we successfully developed and characterized platelet membrane-coated HGF-poly(lactic--glycolic acid) (PLGA) nanoparticles (NPs).

sTREM2 cerebrospinal fluid levels are a potential biomarker in amyotrophic lateral sclerosis and associate with UMN burden.

Objectives: The aims of this study were to investigate whether CSF sTREM2 may be a potential marker of disease monitoring for amyotrophic lateral sclerosis (ALS).

Methods: We investigated whether CSF sTREM2 levels are altered in ALS patients and are correlated with upper motor neuron (UMN) burden and disease progression.

Results: CSF sTREM2 was greater in the ALS patients than in the controls ( = 0.

Comparative efficacy and safety of three endoscopic techniques for the treatment of large common bile duct stones (≥ 15 mm): Long-term follow-up.

Background & Aims: The effectiveness of endoscopic papillary large balloon dilation (EPLBD) alone versus EPLBD combined with endoscopic sphincterotomy (EST) in treating large common bile duct stones (CBDS, ≥ 15 mm) remains unclear. This study aimed to evaluate the safety and treatment outcomes of EPLBD combined with limited or large EST versus EPLBD alone in removing large CBDS.

Methods: Between January 2013 and September 2024, 408 patients underwent EPLBD, either alone or in combination with EST, to treat large CBDS (≥ 15 mm).

When animal viruses meet N-methyladenosine (mA) modifications: for better or worse?

N-methyladenosine (mA) is a prevalent and dynamic RNA modification, critical in regulating gene expression. Recent research has shed light on its significance in the life cycle of viruses, especially animal viruses. Depending on the context, these modifications can either enhance or inhibit the replication of viruses.

Non-, a Treatable Provocateur of Parkinson's Disease: Hypothesis, Evidence and Species Specificity.

Epidemiological and eradication trial evidence indicates that , a major causative factor in peptic ulcer and gastric cancer, is a driver of the hypokinesia of Parkinson's disease (PD). Psychological (cognitive impairment, depression and anxiety) and gastrointestinal (peptic ulceration and constipation) PD features can precede the symptomatic onset of motor features by decades. We hypothesise that the non- (NHPH), which have farm, companion and wild animals as their main hosts, can have a role in PD aetiopathogenesis.

Sesquiterpene lactone from Artemisia argyi inhibited cancer proliferation by inducing apoptosis and ferroptosis via key cell metabolism enzyme NDUFA4.

Background: Artemisia argyi is a well-known medicinal plant. A. argyi has been widely used in clinical for about 3000 years, owing to its extensive pharmacological activity.

Innate Immune Cell Profiling in Peripheral Blood Mononuclear Cells of Patients with Moyamoya Disease.

Moyamoya disease (MMD) is a rare cerebrovascular disease characterized by stenosis or occlusion of the internal carotid artery, thus leading to ischaemic and haemorrhagic strokes. Although genetic studies have identified ring finger protein 213 (RNF213) as a susceptibility gene, the low disease penetrance suggests that a secondary trigger, such as infection, may initiate disease onset. This study aimed to characterize the innate immune cell profile of peripheral blood mononuclear cells (PBMCs) of MMD patients via mass cytometry (CyTOF).

An enzyme-mimicking reactive oxygen species scavenger targeting oxidative stress-inflammation cycle ameliorates IR-AKI by inhibiting pyruvate dehydrogenase kinase 4.

: Ischemia-reperfusion-induced acute kidney injury (IR-AKI), characterized by the abrupt decline in renal function, is distinguished by the intricate interplay between oxidative stress and inflammation. In this study, a reactive oxygen species (ROS) scavenger-CF@PDA was developed to effectively target antioxidant and anti-inflammatory pathways to disrupt the oxidative stress-inflammation cycle in IR-AKI. : UV-vis absorption spectra, FTIR spectra, and TEM were employed to determine the successful construction of CF@P.

mRNA-encoded fluorescent proteins enable superior organelle labeling for live cell imaging.

Live cell labeling of various organelles is of great demand in the research field of cell biology. However, current approaches often lack an optimal balance between efficiency and versatility. We took advantage of chemical modified mRNA to express various organelle located fluorescent proteins.

Blue rubber blister nevus syndrome: A case report.

Background: Blue rubber blister nevus syndrome (BRBNS) is a congenital, rare disease characterized by venous malformations of the skin and internal organs, affecting all systems throughout the body. The pathogenesis is unknown. There is no consensus on the treatment of BRBNS.

Carrier transfer in quasi-2D perovskite/MoS monolayer heterostructure.

Two-dimensional layered semiconductors have attracted intense interest in recent years. The van der Waals coupling between the layers tolerates stacking various materials and establishing heterostructures with new characteristics for a wide range of optoelectronic applications. The interlayer exciton dynamics at the interface within the heterostructure are vitally important for the performance of the photodetector and photovoltaic device.

Prediction Model for Cesarean Scar Disorder Disappearance After Transvaginal Uterine Diverticulum Repair.

Objectives: Cesarean scar disorder (CSD) is a recently defined condition resulting from cesarean delivery (CD) surgery, and transvaginal uterine diverticulum repair (TVUDR) is generally chosen for treatment of CSD. This study constructed a prediction model for CSD disappearance after TVUDR using imaging data for CSD measured by transvaginal ultrasound (TVU), MRI, and contrast-enhanced MRI.

Methods: The data of 283 women with previous CD treated with TVUDR were retrospectively collected between January 2014 and February 2016.

Application of improved ant-lion algorithm for power systems.

An improved ant-lion algorithm is proposed to solve the load allocation problem to improve the efficiency of load allocation in the power system. The global search capability and optimization performance of the algorithm have been significantly improved by introducing elite weights and chaotic search mechanisms. The innovation of the research lies in not only optimizing economic goals, but also considering environmental goals, achieving dual optimization of economy and environment.

Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases.

Alternative splicing contributes to complex traits, but whether this differs in trait-relevant cell types across diverse genetic ancestries is unclear. Here we describe cell-type-specific, sex-biased and ancestry-biased alternative splicing in ~1 M peripheral blood mononuclear cells from 474 healthy donors from the Asian Immune Diversity Atlas. We identify widespread sex-biased and ancestry-biased differential splicing, most of which is cell-type-specific.

Mycobacterium paragordonae pulmonary disease with rapidly growing solitary lesions: a case report and literature review.

Introduction: Mycobacterium paragordonae (MPG) is a novel and uncommon nontuberculous mycobacterium (NTM). We describe a case of MPG pulmonary disease (MPGPD) with a single, rapidly growing, pulmonary mass, which has rarely been reported.

Case Report: A chest CT scan of a 66-year-old woman revealed a rapidly growing solitary mass-like lesion in the upper lobe of the right lung, which was not seen in the previous chest CT scan six months ago.