Engineering NiSe/CoSe heterojunction for enhanced bifunctional Catalysis in Urea-Assisted hydrogen production.

Coupling the hydrogen evolution reaction (HER) with the urea oxidation reaction (UOR) represents a highly promising energy-saving strategy for hydrogen production. However, the development of cost-effective and high-performance bifunctional electrocatalysts remains a challenge. In this study, a NiSe/CoSe heterojunction was constructed via electrodeposition, leveraging interfacial synergy to significantly enhance catalytic performance.

Bile acids alleviate intestinal inflammation by modulating gut microbiota composition in LPS-challenged broilers.

Previous research has identified bile acids (BAs) as a valuable supplement for animal feed, especially in the poultry industry. However, there is limited research on the use of bile acids as a preventative measure against intestinal inflammation in broilers. This study aims to investigate the impact of dietary BAs on LPS-triggered intestinal inflammation in broilers.

Structural and physicochemical properties of debranched lotus seed starch treated with high hydrostatic pressure.

Lotus seeds represent a significant economic crop and are abundant in starch. To further enhance their application value, this study investigates the structural characteristics of lotus seed starch (LS) under the combined influence of pullulanase and high hydrostatic pressure (HHP). Pullulanase increased amylose content from 39.

LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease often treated with glucocorticoids, which can lead to complications such as osteoporosis and an increased infection risk. Hence, identifying safe and effective treatment strategies is crucial. has shown promise in improving immune disorders.

Multifunctional Phase Change Films with High Mechanical Strength, Thermally Induced Switchable Adhesion, and Shape Recoverability for Infrared Stealth.

The application of organic solid-liquid phase change materials (PCMs) is limited for the leakage problem after phase change and high rigidity. In this work, a novel flexible solid-solid PCM (DXPCM) was synthesized using a block copolymerization process with polyethylene glycol (PEG) as the energy storage segment. The phase transition temperature (from 36.

Changes in metabolite profiles in solid fermentation of glutamate waste treatment solution by Aspergillus niger and Candida tropicalis.

Aims: Glutamate wastewater poses a great environmental challenge to the monosodium glutamate production industry. However, its treatment solution is rich in crude protein, which has the potential to be developed as a new protein source for animal feed.

Methods And Results: Given that the fermentation process generates functionally different metabolites, this study innovatively utilized two strains of feed microorganisms, Aspergillus niger and Candida tropicalis, to perform solid-state fermentation of glutamate wastewater treatment solution.

[Regulatory effect of Epimedium flavonoid microparticles on pulmonary pre-metastatic microenvironment].

Tumor metastasis is the main cause of death in clinical patients. The proposal of the pre-metastatic microenvironment hypothesis offers a new research direction for tumor metastasis. Targeting and inhibiting the activation of the stimulator of interferon genes(STING) signals by tumor cell-derived microparticles may help reduce tumor metastasis.

OPG promotes lung metastasis by reducing CXCL10 production of monocyte-derived macrophages and decreasing NK cell recruitment.

Background: Lung metastasis is a critical and often fatal progression in cancer patients, with monocyte-derived macrophages (Mo-macs) playing multifaceted roles in this process. Despite the recognized importance of Mac-macs, most studies focus on these cells themselves, while the precise mechanisms through which tumor cells manipulate Mo-macs to promote metastasis remain poorly understood.

Methods: We developed an in vivo CRISPR screening system to identify genes involved in macrophage-dependent metastasis by depleting Mo-macs.

Fenugreek gum improves the rheological properties of konjac glucomannan in dynamic simulated digestion system and delays its gastric emptying.

The physicochemical properties of konjac glucomannan (KGM) are impaired in the harsh gastrointestinal tract, which may reduce its effectiveness in physiological functions. In this paper, fenugreek gum (FG) with high water holding capacity and stability was used as a gastric protectant for KGM, and the effects of the KGM-FG complexes with different composite ratios on gastric emptying were researched by in vitro dynamic simulated gastric digestion system. The results showed that FG significantly enhanced the delayed gastric emptying properties of KGM.

Interaction mechanism, fabrication strategies, and advanced applications of konjac glucomannan-based mixed polysaccharide systems.

Due to its high viscoelasticity and positive health benefits, konjac glucomannan (KGM)-based mixed polysaccharide systems are widely applied in food processing and pharmaceuticals. However, a knowledge gap exists between the relationship between KGM interactions with different polysaccharides and the resulting food processing properties and health benefits. This review elaborately aims to address this research gap by analyzing the literature on the updated KGM-based binary thermodynamic compatibility systems, classified and discussed according to the basic gel models.

Corrigendum: Immunological characteristics of a recombinant alphaherpesvirus with an envelope-embedded protein of circovirus.

[This corrects the article DOI: 10.3389/fimmu.2024.

Digestive characteristics and structural changes of lotus seed starch-lotus seed protein blend system during in vitro digestion.

This study analyzes the digestive characteristics, morphological changes, particle size distribution, and the evolution of crystalline and molecular structures of the lotus seed starch-lotus seed protein blend system (LS-LP) through simulated in vitro static and dynamic digestion experiments. The findings indicate that LS-LP, treated by high-pressure homogenization (HPH), exhibits a higher digestion rate and total digestibility compared to the physical mixture of lotus seed starch and protein (PM) and lotus seed starch (LS). Interestingly, scanning electron microscopy (SEM) observations reveal that during digestion, the structure of lotus seed protein (LP) changes, forming a physical barrier to LS, thereby partially slowing down the digestion process.

A bulk Schottky junction for high-sensitivity portable radiation detectors.

The thickness of X-ray detectors needs to reach hundreds of micrometers to absorb X-ray, and therefore, high voltages over tens or hundreds of volts should be applied to extract X-ray-generated carriers. Here, we propose a bulk Schottky junction for X-ray detection using interpenetrated macroporous-carbon electrodes and metal-halide perovskite networks. The X-ray-generated holes are extracted by the macroporous-carbon electrodes under the built-in electric field, while the electrons in the perovskite phase result in a high gain effect.

Litter Removal Counteracts the Effects of Warming on Soil Bacterial Communities in the Qinghai-Tibet Plateau.

Climate warming and high-intensity human activities threaten the stability of alpine meadow ecosystems. The stability of the soil microbial community is crucial for maintaining ecological service function. However, the effects of warming and litter removal on microbial interactions, community-building processes, and species coexistence strategies remain unclear.

Pharmacovigilance study of famciclovir in the Food and Drug administration adverse event reporting system database.

Famciclovir, mainly used to treat herpes zoster, is rapidly transforms into penciclovir when administered orally. Our study evaluated adverse events (AEs) associated with famciclovir by mining data from the publicly available Food and Drug Administration Adverse Event Reporting System (FAERS) database, providing a reference for clinical safety. Disproportionality analysis (including reported odds ratio and proportional reporting ratio) and Bayesian methods (including Bayesian Confidence Propagation Neural Network and Gamma-Poisson Shrinkage) were used to quantify the AE signals associated with famciclovir.

A Novel Cell- and Virus-Free SARS-CoV-2 Neutralizing Antibody ELISA Based on Site-Specific Labeling Technology.

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the global spread of coronavirus disease 2019 (COVID-19), creating an urgent need for updated methods to evaluate immune responses to vaccines and therapeutic strategies. In this study, we introduce a novel cell-free, virus-free SARS-CoV-2 neutralizing antibody ELISA (NAb-ELISA), which is based on competitive inhibition of the receptor binding domain (RBD) of spike protein binding to the angiotensin-converting enzyme 2 (ACE2) receptor. In this method, site-specific biotinylated hACE2-Fc-Avi recombinant protein is immobilized onto a 96-well plate for capture, and the RBD-Fc-vHRP recombinant proteins serve as detection probes.

Inhibits Appetite of Obese Mice by Suppressing Hypothalamic Inflammatory Response and / Neuron Expression.

(KGM) is used for appetite management. However, KGM's regulation of appetite through hypothalamic neurons and gut microbiota, particularly in nonobese populations, is required to be investigated. This study investigated the differential effects of KGM on appetite and energy metabolism in obese and nonobese mice.

Association of Physical Activity with Asthma and Chronic Obstructive Pulmonary Disease and Mediation of Frailty: Mendelian Randomization Analyses.

Background: The existence of an association between physical activity (PA) and asthma and chronic obstructive pulmonary disease (COPD) has been confirmed in observational studies. Therefore, it is necessary to reveal whether there is a risk-effect relationship between physical activity and asthma and COPD through Mendelian randomization (MR) analysis.

Materials And Methods: Univariate Mendelian randomization (UVMR) analyses were performed to examine the associations between moderate to vigorous physical activity (MVPA), vigorous physical activity (VPA), accelerometer-assessed physical activity (AA), and strenuous exercise or other exercise (SSOE) with asthma and COPD.

Controllable Synthesis and Ultrahigh Proton Conduction of a Hydrogen-Bond Network.

The functionalization of polyoxometalates with organic ligands provides a new-style strategy to accurately incorporate polyoxometalates with advanced functional organic moieties on their surfaces, the development of which has attracted increasing research interest due to the potential applications. A germanium tungstate Na(HO)[{Ru(bpy)}{WO(CO)}(GeWO)]·27HO (bpy = 2,2'-bipyridine) with two ligands covalently modified was triumphantly synthesized, using the conventional one-pot hydrothermal method. It was systematically characterized by thermogravimetric analysis (TGA), elemental analysis, infrared (IR) spectroscopy, single-crystal X-ray diffraction, X-ray photoelectron spectroscopy (XPS), powder diffraction (PXRD), scanning electronic microscopy (SEM), and ultraviolet-visible (UV-vis) spectroscopy.

ERK1/2 interaction with DHPS regulates eIF5A deoxyhypusination independently of ERK kinase activity.

This study explores a non-kinase effect of extracellular regulated kinases 1/2 (ERK1/2) on the interaction between deoxyhypusine synthase (DHPS) and its substrate, eukaryotic translation initiation factor 5A (eIF5A). We report that Raf/MEK/ERK activation decreases the DHPS-ERK1/2 interaction while increasing DHPS-eIF5A association in cells. We determined the cryoelectron microscopy (cryo-EM) structure of the DHPS-ERK2 complex at 3.