Palladium-Catalyzed Stereospecific Glycosylation Enables Divergent Synthesis of N-O-Linked Glycosides.

We present a versatile palladium-catalyzed glycosylation platform that enables facile access to structurally diverse N-O-linked glycosides with constantly excellent regio- and stereoselectivities. Importantly, this approach offers a broad substrate scope, low catalyst loadings, and outstanding chemoselectivity, allowing for the selective reaction of oximes/hydroximic acids over hydroxyl groups that would otherwise pose challenges in conventional glycosylation methods. The synthetic utility of this method is further exemplified through a range of synthetic transformations and late-stage modification of bioactive molecules.

A nomogram predicting the risk of venous thromboembolism in patients following urologic surgeries.

There are inconsistent results pertaining to risk factors for venous thromboembolism (VTE) in patients following urologic surgeries. We attempted to establish a visualization model to shed further light upon this topic. Consequently, a total of 436 patients who were tested for VTE following urologic surgeries were retrospectively enrolled.

Prognostic Value of Coronary CT Angiography-Derived Quantitative Flow Ratio in Suspected Coronary Artery Disease.

Background The prognostic value of coronary CT angiography (CTA)-derived quantitative flow ratio (CT-QFR) remains unknown. Purpose To determine the prognostic value of CT-QFR in predicting the long-term outcomes of patients with suspected coronary artery disease (CAD) in comparison with invasive coronary angiography (ICA)/SPECT and to determine the influence of prior percutaneous coronary intervention (PCI) on the prognostic value of CT-QFR. Materials and Methods In this secondary analysis of the prospective international CORE320 study, 379 participants who underwent coronary CTA and SPECT within 60 days before ICA between November 2009 and July 2011 were included for follow-up.

Graph Batch Coarsening framework for scalable graph neural networks.

Due to the neighborhood explosion phenomenon, scaling up graph neural networks to large graphs remains a huge challenge. Various sampling-based mini-batch approaches, such as node-wise, layer-wise, and subgraph sampling, have been proposed to alleviate this issue. However, intensive random sampling incurs additional overhead during training and often fails to deliver good performance consistently.

PhAN2 regulated Ph3GT silencing changes the flower color and anthocyanin content in petunias.

Anthocyanins are important secondary metabolites in plants. After the formation of anthocyanidins, Flavonoid 3-O-glucosyltransferase (3GT) mediated glycosylation first occurs at the C-3 site, forming a stable anthocyanin 3-O-glucoside. Several studies have investigated the function of 3GT using biochemical methods.

Spatiotemporal Programmability of 3D Chiral Color Units Driven by Ink Spontaneous Diffusion toward Customized Printing.

Blue phase liquid crystals (BPLCs) have exhibited promising applications in 3D flexible displays due to their molecular-level self-assembled chiral structures, fast response, and tunable polarized colors. However, there remain challenges for spatiotemporal programming of 3D chiral color units for BPLC dynamic patterning. Herein, the programmable temporal evolution of micrometer-scale color units and spatial configuration switch of chiral modes are achieved by spontaneous ink diffusion-driven asymmetric lattice deformation in dual-chiral polymer-templated blue phases.

Investigating the peri-saphenous vein graft fat attenuation index on computed tomography angiography: relationship with progression of venous coronary artery bypass graft disease and temporal trends.

Background: To clarify the fat attenuation index (FAI) change trend of peri-saphenous vein graft (SVG) and determine the association between FAI and graft disease progression based on CCTA images.

Methods: Patients with venous coronary artery bypass grafts (CABGs) were consecutively enrolled in this retrospective study. In study 1, 72 patients who had undergone 1, 3, and 5 years of CCTA examinations without graft occlusion were recruited, and generalized estimation equation was used to analyze the peri-SVG FAI change trend over time.

Dan'e fukang decoction reduces hemorrhage in a rat model of mifepristone induced incomplete abortion and may correlate with cell adhesion molecule signaling interference.

Ethnopharmacological Relevance: Dan'e fukang decoction (DFD) is a traditional Chinese medicine formula. DFD obtains 10 herbs, including Salvia yunnanensis C.H.

Hierarchical zeolite-encapsulated metal nanoparticles for heterogeneous catalysis.

Zeolites, characterized by their highly porous structure, have become integral to modern industry and environmental science due to their broad applications in adsorption, separation, and catalysis. Recent advancements in zeolite synthesis, particularly through hydrothermal methods and the incorporation of metal nanoparticles, have significantly expanded their utility. This review delves into the innovative strategies for encapsulating metal nanoparticles within zeolite matrices, enhancing catalytic reactions' efficiency, selectivity, and durability.

Performance of iodine quantification through high-pitch dual-source photon-counting CT: a phantom study.

Purpose: To investigate the feasibility and accuracy of iodine quantification using PCD-CT in standard-pitch and high-pitch scanning at different scan parameters in a phantom model.

Materials And Methods: Four inserts with known iodine concentrations (2, 5, 10, and 15 mg/mL) were placed in the removable CT phantom and scanned using high-pitch (3.2) and standard-pitch (0.

RVD2 emerges as a serological marker in relation to severity and six-month clinical outcome following acute intracerebral hemorrhage: A prospective cohort study from a single academic institution.

Background: Resolvin D2 (RvD2), with an anti-inflammatory activity, harbors a neuroprotective property. Here, serum RvD2 levels were detected with an attempt to explore its prognostic implication in human acute intracerebral hemorrhage (ICH).

Methods: In this prospective cohort study, serum RvD2 levels of 301 ICH patients, coupled with 100 heathy individuals, were gauged.

The divisome is a self-enhancing machine in Escherichia coli and Caulobacter crescentus.

During bacterial cytokinesis, polymers of the bacterial tubulin FtsZ coalesce into the Z ring to orchestrate divisome assembly and septal cell wall synthesis. Previous studies have found that Z ring condensation and stability is critical for successful cell division. However, how FtsZ filaments condense into a Z ring remains enigmatic and whether septal cell wall synthesis can feedback to the Z ring has not been investigated.

Wee1 inhibitor PD0166285 sensitized TP53 mutant lung squamous cell carcinoma to cisplatin via STAT1.

Background: Lung squamous cell carcinoma (LUSCs) is associated with high mortality (20-30%) and lacks of effective treatments. Almost all LUSC exhibit somatic mutations in TP53. Wee1, a tyrosine kinase, regulates the cell cycle at the G2/M checkpoint.

Single-cell and spatial transcriptome assays reveal heterogeneity in gliomas through stress responses and pathway alterations.

Background: Glioma is a highly heterogeneous malignancy of the central nervous system. This heterogeneity is driven by various molecular processes, including neoplastic transformation, cell cycle dysregulation, and angiogenesis. Among these biomolecular events, inflammation and stress pathways in the development and driving factors of glioma heterogeneity have been reported.

Two Birds with One Stone: Impedance-Voltage Dual-Mode Low Humidity Sensor Based on LiBr-MOF-801 with High Response.

Dual-mode humidity sensors have received wide attention in recent years due to their great potential in multifunction applications. Herein, following a "two birds with one stone" strategy, a dual-mode and self-powered low humidity sensor based on LiBr-MOF-801 with high response and power generation is proposed. The optimized LiBr-MOF-801-based sensor exhibits impedance-voltage dual-mode sensitivity in the low humidity range of 0-23% relative humidity (RH) with high response (57.

A two-center prospective cohort study of serum RIP-3 as a potential biomarker in relation to severity and prognosis after severe traumatic brain injury.

Receptor-interacting protein kinase-3 (RIP-3) is a key component for inducing necroptosis following acute brain injury. Purpose of this study is to unveil whether serum RIP-3 levels are related to severity and clinical outcomes after human severe traumatic brain injury (sTBI). In this two-center prospective cohort study, serum RIP-3 levels were detected in 127 healthy controls coupled with 127 sTBI patients.

Vanillin-based flame retardant enables polylactic acid high-efficiency fireproof, anti-UV and oxygen barrier for food packaging.

Polylactic acid (PLA) is widely known for its biocompatibility, biodegradability, and high transparency. However, it still has varied limitations such as flammability, UV sensitivity, and poor oxygen barrier properties. To address these issues, a bio-based compound, hexasubstituted cyclotriphosphazene (HVP), was synthesized by using vanillin and hexachlorocyclotriphosphazene to enhance the overall performance of PLA.

Temperature-Sensitive Template for Preparation of ZnO/CeO Composite Photocatalytic Materials and Its Catalytic Performance.

In this work, a series of thermosensitive ionic liquid functionalized polymers, PN(IL), with controllable morphology and particle size were prepared by free radical polymerization. Then, using the polymer PN(IL) with uniform morphology as a templating agent, the ZnO composite photocatalytic materials doped with rare earth metal Ce were prepared in combination with a microwave-assisted and templated hydrothermal reaction method. Series different Ce-doping amount photocatalytic materials ZnO-Ce-x‱ were characterized by XRD, SEM, TEM, XPS, and other methods.

DF-1-Derived exosomes mediate transmission of reticuloendotheliosis virus and resist REV-specific antibodies.

Background: Reticuloendotheliosis virus (REV), a member of the family Retroviridae, is a hot area of research, and a previous study showed that exosomes purified from REV-positive semen were not blocked by REV-specific neutralizing antibodies and established productive infections.

Methods: To further verify the infectivity of exosomes from REV-infected cells, we isolated and purified exosomes from REV-infected DF-1 cells and identified them using Western blot and a transmission electron microscope. We then inoculated 7-day-old embryonated eggs, 1-day-old chicks and 23-week-old hens with and without antibody treatment.

Physiologically Based Pharmacokinetic Model for Predicting Omadacycline Pharmacokinetics and Pharmacodynamics in Healthy and Hepatic Impairment Populations.

Purpose: Omadacycline is a new broad-spectrum aminomethylcycline antibiotic. However, there have been limited pharmacokinetic and pharmacodynamic (PK/PD) studies of omadacycline in patients with hepatic impairment. The aim of this study was to explore the PK/PD of omadacycline intravenous administration in healthy and hepatically impaired populations.

The Identification of Oral Cariogenic Bacteria through Colorimetric Sensor Array Based on Single-Atom Nanozymes.

Effective identification of multiple cariogenic bacteria in saliva samples is important for oral disease prevention and treatment. Here, a simple colorimetric sensor array is developed for the identification of cariogenic bacteria using single-atom nanozymes (SANs) assisted by machine learning. Interestingly, cariogenic bacteria can increase oxidase-like activity of iron (Fe)─nitrogen (N)─carbon (C) SANs by accelerating electron transfer, and inversely reduce the activity of Fe─N─C further reconstruction with urea.