alleviates LPS-induced depressive behavior via enhancing the abundance of spp.

The rising incidence rate of depression presents a substantial threat to human well-being. (ST), the dried mature seeds of L., has a long-standing traditional reputation for alleviating anxiety and hopelessness.

Ocular inflammation in tsutsugamushi disease - a case report.

A 64-year-old male, working at a mountain site in Taitung County, suffered from primary open angle glaucoma (POAG) post trabeculectomy with well-controlled intraocular pressure (IOP) in both eyes (OU). He presented with headache accompanied by red eyes (OU) for 10 days. Physical examination revealed fever up to 38.

Detrended seasonal relationships and impact of climatic factors combined with spatiotemporal effect on the prevalence of human brucellosis.

Human brucellosis (HB) is a seasonal and climate-affected infectious disease that is posing an increasing threat to public health and economy. However, most of the research on the seasonal relationships and impact of climatic factors on HB did not consider the secular trend and spatiotemporal effect related to the disease. We herein utilized long-term surveillance data on HB from 2008 to 2020 using sinusoidal models to explore detrended relationships between climatic factors and HB.

Lung protective effects of dietary malate esters derivatives from against SiO nanoparticles through activation of Nrf2 pathway.

Objective: To study the protective activities of the dietary malate esters derivatives of against SiO nanoparticles-induced A549 cell lines and its mechanism action.

Methods: The components were isolated and elucidated by spectroscopic methods such as 1D NMR and 2D NMR. And MTT assays was used to tested these components on the A549 cell survival rates and ROS or proteins levels were detected by Western blotting.

Exploring risk transfer of human brucellosis in the context of livestock agriculture transition: A case study in Shaanxi, China.

With the booming of worldwide agriculture intensification, brucellosis, one of the most neglected zoonotic diseases, has become an increasing challenge for global public health. Although the transmission patterns of human brucellosis (HB) have been studied in many regions, the dynamic transfer processes of risk and its driving factors remain poorly understood, especially in the context of agricultural intensification. This study attempted to explore the risk transfer of HB between the exact epidemic areas and the neighboring or distant low-risk areas to explain the impact of livestock agriculture intensification and foodborne infections on the transmission of HB in Shaanxi Province as a case study.

Exploring Anticancer Activities and Structure-Activity Relationships of Binuclear Oxidovanadium(IV) Complexes.

Dimeric mixed-ligand oxidovanadium complexes [VO(1,3-pdta)(bpy)]·9HO () and [VO(1,3-pdta)(phen)]·6HO () feature a symmetric binuclear structure bridged by 1,3-pdta, which is different from our previous reported asymmetric binuclear complex [VO(edta)(phen)]·11HO ().In this study, a wide range of analytical techniques were carried out to fully characterize the complexes and and further investigate their structural stabilities. Density functional theory calculations of and also suggest that they might have good reactivity with biomolecules as anticancer agents.

Brucellosis Outbreak Caused by - Jingyang County, Shaanxi Province, China, March-May, 2020.

Brucellosis is one of the world's most overlooked zoonotic diseases, and humans can easily acquire brucellosis from animals and their products. Reemerging brucellosis outbreaks are probably attributable to sociocultural factors and compounded by the lack of adequate control measures in sheep and goat rearing systems. This is the first identified outbreak caused by bv.

Seroprevalence trend of human brucellosis and MLVA genotyping characteristics of Brucella melitensis in Shaanxi Province, China, during 2008-2020.

In this study, a total of 179,907 blood samples from populations with suspected Brucella spp. infections were collected between 2008 and 2020 and analyzed by the Rose Bengal plate test (RBPT) and serum agglutination test (SAT). Moreover, conventional biotyping, B.

Apigenin exerts chemopreventive effects on lung injury induced by SiO nanoparticles through the activation of Nrf2.

Apigenin (APG) is a flavonoid widely distributed in fruits, vegetables, and herbs, with comprehensive pharmacological effects. In this paper, we report that APG can elicit a protective effect, which is comparable to those induced by gymnoside II/n-BuOH extracts of Bletilla striata, on SiO-induced lung injury in vitro and in vivo. In vitro experiments showed that APG (25 μM) could restore the SiO-decreased A549 cell viability and lower the apoptotic rate and the production of intracellular reactive oxygen species (ROS) in A549 cells treated with nm SiO.

n-BuOH extract of Bletilla striata exerts chemopreventive effects on lung against SiO nanoparticles through activation of Nrf2 pathway.

Background: SiO nanoparticles (nm SiO) are ubiquitous in daily life and are acknowledged to be detrimental to human health. Bletilla striata is a traditional medicine used for generations in China and its polysaccharide has the anti-pulmonary fibrosis effect.

Purpose: To investigate the lung protective effect of the small molecules (n-BuOH extract) of B.

NR2F2 plays a major role in insulin-induced epithelial-mesenchymal transition in breast cancer cells.

Background: The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes mellitus (T2DM), has been regarded as a key risk factor for the progression of breast cancer. Nuclear receptor subfamily 2, group F, member 2 (NR2F2) has been implicated in the development of breast cancer, however its contribution to insulin-induced EMT in breast cancer remains unclear.

Licochalcone A reverses NNK-induced ectopic miRNA expression to elicit in vitro and in vivo chemopreventive effects.

Background: Chemoprevention is the best cost-effective way regarding cancers. MicroRNAs (miRNAs) have been reported to be differentially expressed during the development of lung cancer. However, if lung cancer prevention can be achieved through modulating miRNAs expression so far remains unknown.

Epidemiological Features and Risk Factors for Acquiring Hepatitis B, Hepatitis C, and Syphilis in HIV-Infected Patients in Shaanxi Province, Northwest China.

Human immunodeficiency virus (HIV)-infected patients are at a higher risk for co-infection with Hepatitis B virus (HBV), Hepatitis C virus (HCV), and Treponema pallidum (TP; the agent causing syphilis) than the general population. The prevalence of HBV, HCV, and syphilis has geographic differences and varies from region to region among HIV-positive individuals. A retrospective study was carried out on HIV-positive individuals between June 2011 and June 2016 in Shaanxi Province.

Stilbenes from the tubers of Bletilla striata with potential anti-neuroinflammatory activity.

Neuroinflammation are involved in the pathogenesis of many neurodegenerative disorders. In our screening of natural effective neuroinflammatory inhibitors from natural products, stilbenes, such as resveratrol and its analogues, have received considerable attention over the last several decades as anti-neuroinflammatory agents. Then, Bletilla striata attracted our attention due to its abundant stilbenes portion, PE fraction.

HIV-1 genetic diversity and recombinant forms among men who have sex with men at a sentinel surveillance site in Xi'an City, China.

HIV-1 genetic distribution and recombinant patterns are important in understanding the HIV epidemic among men who have sex with men (MSM). In this study, 83 HIV-positive MSM infections were confirmed at a sentinel surveillance site in Xi'an city, China in 2018. HIV-1 genotypes were determined by phylogenetic analyses of HIV-1 gag, pol and env gene fragments, including CRF07_BC (51.

Lactoferrin Protects Hyperoxia-Induced Lung and Kidney Systemic Inflammation in an In Vivo Imaging Model of NF-κB/Luciferase Transgenic Mice.

Purpose: High levels of oxygen are usually used in ventilatory support and extracorporeal membrane oxygenation (ECMO) in the intensive care unit of hospitals. Hyperoxia may induce the production of reactive oxygen species (ROS) that can cause lung damage and even systemic injury. In this study, the NF-κB/luciferase transgenic mouse model with non-invasive real-time in vivo imaging was established to test the functions of lactoferrin (LF) in antioxidant and anti-inflammation.

Identification of Three HIV-1 Unique (B/C) Recombinant Forms in Shaanxi, China.

HIV-1 intersubtype B/C recombinants were more commonplace reported in high-risk populations in Yunnan province, China. In this study, three unique (B/C) recombinant isolates (2015YL02, 2018YL07, and SN18015) were identified from patients infected with HIV-1 through sexual transmission in Shaanxi province. Phylogenetic and bootscan analyses showed that three recombinants comprised HIV-1 subtype B and subtype C.

Antiproliferative steroidal glycosides from rhizomes of Polygonatum sibiricum.

Screening assays showed that total glycoside-rich fraction (TG) of rhizomes of Polygonatum sibiricum unveiled remarkable anti-proliferative activities against three cancer cell lines (A549, HepG2, and Caco2). Activity-guided isolation of TG afforded seven undescribed steroidal glycosides (polygonosides 1-7), along with 24 known glycosides. Their structures were established by 1D and 2D NMR spectroscopic analyses, high-resolution mass spectrometry, and chemical evidence.

Identification of Two Novel HIV-1 Second-Generation Recombinant Forms (CRF01_AE/07_BC) in Shaanxi, China.

Sexual contact is the main route of transmission of HIV type 1 (HIV-1) pandemic in China. New unique recombinant forms (URFs) were increasingly characterized in sexual populations in recent years. We reported two URFs identified from two male HIV-1-positive patients who were infected through sexual exposure in Shaanxi, China.

Investigation of Zinc and Phosphorus Elements Incorporated into Micro-Arc Oxidation Coatings Developed on Ti-6Al-4V Alloys.

In order to clarify the mechanism that zinc and phosphorus elements entering the micro-arc oxidation (MAO) coatings developed on Ti-6Al-4V alloys, anodic coatings containing different zinc and phosphorus were fabricated using an orthogonal experiment of four factors with three levels in an electrolyte containing EDTA-ZnNa₂, KOH, and phytic acid. Surface morphology, element composition, chemical state and phase structure of MAO coatings were characterized by scanning electron microscope (SEM), energy dispersive X-ray spectrometer (EDS), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD). The concentrations of zinc and phosphorus in the electrolyte were analyzed by an inductively coupled plasma optical emission spectrometry (ICP-OES).