The association between triglyceride -glucose index and stress urinary incontinence in adult American women: A population-based study.

Purpose: This investigation seeks to determine the triglyceride glucose (TyG) index's link to stress urinary incontinence (SUI) in American females of adult age.

Methods: The investigation relied on data acquired via the National Health and Nutrition Examination Survey (NHANES) conducted over the period from 2011 to 2018. The independent relationship between TyG index and SUI was tested using multivariate logistic regression analysis.

Effects of temperature, pH, and relative humidity on the growth of Penicillium paneum OM1 isolated from pears and its patulin production.

Patulin is a mycotoxin produced by several species of Penicillium sp., Aspergillus sp., and Byssochlamys sp.

Two cooperative binding sites sensitize PI(4,5)P recognition by the tubby domain.

Phosphoinositides (PIs) are lipid signaling molecules that operate by recruiting proteins to cellular membranes via PI recognition domains. The dominant PI of the plasma membrane is phosphatidylinositol 4,5-bisphosphate [PI(4,5)P]. One of only two PI(4,5)P recognition domains characterized in detail is the tubby domain.

Stability and bifurcation control analysis of a delayed fractional-order eco-epidemiological system.

Considering the factor of artificial intervention in biological control, a delayed fractional eco-epidemiological system with an extended feedback controller is proposed. By using the digestion delay as bifurcation parameter, the stability and Hopf bifurcation are investigated, and the branching conditions are given. The system undergoes Hopf bifurcation, when the parameter passes through the critical value.

Constructing zigzag-like hollow mesoporous nanospheres MoO/C with superior lithium storage performance.

Hollow mesoporous nanospheres MoO/C are successfully constructed through metal chelating reaction between molybdenum acetylacetone and glycerol as well as the Kirkendall effect induced by diammonium hydrogen phosphate. MoOnanoparticles coupled by amorphous carbon are assembled to unique zigzag-like hollow mesoporous nanosphere with large specific surface area of 147.7 mgand main pore size of 8.

Deterministic and stochastic dynamics of a modified Leslie-Gower prey-predator system with simplified Holling-type Ⅳ scheme.

In this paper, a prey-predator model with modified Leslie-Gower and simplified Holling-type Ⅳ functional responses is proposed to study the dynamic behaviors. For the deterministic system, we analyze the permanence of the system and the stability of the positive equilibrium point. For the stochastic system, we not only prove the existence and uniqueness of global positive solution, but also discuss the persistence in mean and extinction of the populations.

Orphan G Protein-Coupled Receptor GPRC5B Controls Smooth Muscle Contractility and Differentiation by Inhibiting Prostacyclin Receptor Signaling.

Background: G protein-coupled receptors are important regulators of contractility and differentiation in vascular smooth muscle cells (SMCs), but the specific function of SMC-expressed orphan G protein-coupled receptor class C group 5 member B (GPRC5B) is unclear.

Methods: We studied the role of GPRC5B in the regulation of contractility and dedifferentiation in human and murine SMCs in vitro and in iSM--KO (tamoxifen-inducible, SMC-specific knockout) mice under conditions of arterial hypertension and atherosclerosis in vivo.

Results: Mesenteric arteries from SMC-specific -KOs showed ex vivo significantly enhanced prostacyclin receptor (IP)-dependent relaxation, whereas responses to other relaxant or contractile factors were normal.

Transurethral endoscopic submucosal en bloc dissection for nonmuscle invasive bladder cancer: A comparison study of HybridKnife-assisted versus conventional dissection technique.

Subjects: The aim of this study is to compare the efficacy and safety of en bloc bladder tumor-endoscopic submucosal dissection (BT-ESD) and conventional transurethral resection of BT (TURBT) in nonmuscle invasive bladder cancer (NMIBC) patients.

Methods: A retrospective cohort study was carried out in Shaanxi Provincial People's Hospital. A total of 193 eligible NMIBC (Ta/T1) patients were enrolled in this study (95 cases in BT-ESD group and 98 cases in TURBT group), between November 2013 and January 2017.

Silibinin suppresses bladder cancer cell malignancy and chemoresistance in an NF-κB signal-dependent and signal-independent manner.

Because bladder cancer (BCa) is the 9th most common malignant tumor and 13th leading cause of death due to cancer, therapeutic approaches have attracted a great deal of attention from both clinicians and BCa patients. Although the development of surgery and targeted drugs has brought new challenges for the traditional concept of BCa therapy, various types of chemotherapy remain the final treatment method for many BCa patients. However, chemoresistance inevitably appears, leading to the failure of chemotherapy.

SPOP promotes tumor progression via activation of β-catenin/TCF4 complex in clear cell renal cell carcinoma.

Renal cell carcinoma (RCC) is the most common type of kidney cancer, about one third of the cases are diagnosed at advanced stages with metastases and effective treatments for metastatic RCC are lacking. The molecular events supporting RCC progression remain poorly understood. SPOP, an E3 ubiquitin ligase component, was recently showed to sufficiently promote RCC tumorigenesis, however, other potential functions of SPOP in RCC have not been studied.