Mapping environmental noise of Guangzhou based on land use regression models.

Background: Environmental noise seriously affects people's health and life quality, but there is a scarcity of noise exposure data in metropolitan cities and at nighttime, especially in developing countries.

Objective: This study aimed to assess the environmental noise level by land use regression (LUR) models and create daytime and nighttime noise maps with high-resolution of Guangzhou municipality.

Methods: A total of 100 monitoring sites were randomly selected according to population density.

Thrust-dominated unilateral rupture of a blind listric fault associated with the 2024 Hualien earthquake.

The 2024 Hualien M 7.4 earthquake struck the Longitudinal Valley, which accommodates the partial collision between the Eurasian and Philippine Sea plates. As the most significant event in Taiwan since the 1999 Chi-Chi M 7.

Enhanced therapeutic potential of a self-healing hyaluronic acid hydrogel for early intervention in osteoarthritis.

Osteoarthritis (OA) is characterized by symptoms such as abnormal lubrication function of synovial fluid and heightened friction on the cartilage surface in its early stages, prior to evident cartilage damage. Current early intervention strategies employing lubricated hydrogels to shield cartilage from friction often overlook the significance of hydrogel-cartilage adhesion and enhancement of the cartilage extracellular matrix (ECM). Herein, we constructed a hydrogel based on dihydrazide-modified hyaluronic acid (HA) (AHA) and catechol-conjugated aldehyde-modified HA (CHA), which not only adheres to the cartilage surface as an effective lubricant but also improves the extracellular environment of chondrocytes in OA.

Improving signal-to-noise ratio of Raman measurements based on ensemble learning approach.

Raman spectroscopy is an extensively explored vibrational spectroscopic technique to analyze the biochemical composition and molecular structure of samples, which is often assumed to be non-destructive when carefully using proper laser power and exposure time. However, the inherently weak Raman signal and concurrent fluorescence interference often lead to Raman measurements with a low signal-to-noise ratio (SNR), especially for biological samples. Great efforts have been made to develop experimental approaches and/or numerical algorithms to improve the SNR.

Toward an advanced physics-based scheme for retrieving land surface emissivity and temperature based on Fengyun-3D MERSI-II daytime mid-infrared data.

The hybrid nature of the mid-infrared (MIR) spectrum complicates the separation of reflected solar irradiance from total energy. Consequently, existing studies rarely use MIR satellite data alone for retrieving land surface temperature (LST) and land surface emissivity (LSE). In this study, we developed What we believe to be a novel physics-based approach to retrieve LSE and LST using MIR channel data from the MEdium Resolution Spectral Imager II (MERSI-II) onboard China's new-generation polar-orbiting meteorological satellite Fengyun-3D (FY-3D).

KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated mA modification of ATG4a to promote NPCs senescence and IVDD progression.

Intervertebral disc degeneration (IVDD), a disease associated with ageing, is characterised by a notable increase in senescent nucleus pulposus cells (NPCs) as IVDD progresses. However, the specific mechanisms that regulate the senescence of NPCs remain unknown. In this study, we observed impaired autophagy in IVDD-NPCs, which contributed to the upregulation of NPCs senescence and the senescence-associated secretory phenotype (SASP).

Electroacupuncture alleviated post-stroke cognitive impairment via the mTOR/NLRP3-mediated autophagy-inflammatory pathway.

Background: Post-stroke cognitive impairment (PSCI) severely reduces quality of life of patients with stroke. This study aimed to assess the effects of electroacupuncture (EA) on PSCI and the role of the mTOR/NLRP3-mediated autophagy-inflammatory pathway in this process.

Methods: The rat focal cerebral ischemia model was established using middle cerebral artery occlusion (MCAO).

Regioselective tungsten-catalyzed decarboxylative amination of allylic alcohols with isocyanates.

Highly regioselective tungsten (W)-catalyzed decarboxylative allylic amination of allylic carbamates has been developed. Allylic carbamates can be generated from readily available allylic alcohols and commercially available isocyanates. In the presence of a tungsten catalyst, branched allylic amines could be obtained in moderate to good yields with excellent regioselectivities (b/l > 20 : 1), and CO is the only byproduct.

Career adaptability and correlating factors among secondary vocational nursing students in China.

Background: Career adaptability significantly affects college students' career happiness in the future, and it is essential to make a detailed evaluation of its correlation for making a targeted intervention plan. However, the applicability of occupational adaptability to secondary vocational nursing students is still an unexplored field in academic research.

Objective: This study aimed to investigate the current situation of career adaptability and its influencing factors on secondary vocational nursing students in medical schools.

Nucleotide polymorphism-based study utilizes human plasma liposomes to discover potential therapeutic targets for intervertebral disc disease.

Background: While intervertebral disc degeneration (IVDD) is crucial in numerous spinally related illnesses and is common among the elderly, the complete understanding of its pathogenic mechanisms is still an area of ongoing study. In recent years, it has revealed that liposomes are crucial in the initiation and progression of IVDD. However, their intrinsic mediators and related mechanisms remain unclear.

The impact of quercetin and paclitaxel combination on ovarian cancer cells.

Ovarian cancer is a highly lethal gynecological malignancy, emphasizing the need for effective treatment strategies. This study investigated the synergistic effects of quercetin and paclitaxel on ovarian cancer. Using SKOV3 and A2780 cell lines, we found that the combined treatment significantly enhanced cell apoptosis and inhibited invasion and migration compared to individual treatments.

Risk prediction models for diabetic nephropathy among type 2 diabetes patients in China: a systematic review and meta-analysis.

Objective: This study systematically reviews and meta-analyzes existing risk prediction models for diabetic kidney disease (DKD) among patients with type 2 diabetes, aiming to provide references for scholars in China to develop higher-quality risk prediction models.

Methods: We searched databases including China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP Chinese Science and Technology Journal Database, Chinese Biomedical Literature Database (CBM), PubMed, Web of Science, Embase, and the Cochrane Library for studies on the construction of DKD risk prediction models among type 2 diabetes patients, up until 28 December 2023. Two researchers independently screened the literature and extracted and evaluated information according to a data extraction form and bias risk assessment tool for prediction model studies.

PCSK9 inhibitors and osteoporosis: mendelian randomization and meta-analysis.

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors represent an effective strategy for reducing cardiovascular disease risk. Yet, PCSK9's impact on osteoporosis remains unclear. Hence, we employed Mendelian randomization (MR) analysis for examining PCSK9 inhibitor effects on osteoporosis.

Global prevalence of obesity in patients with psoriasis: An analysis in the past two decades.

Background: Obesity is the risk factor for psoriasis. Therefore, we conducted a comprehensive review and meta-analysis to determine the prevalence of obesity in patients with psoriasis.

Methods: We examined four databases from their inception to October 2023 and used the Agency for Healthcare Research and Quality and the Newcastle-Ottawa Scale to assess the quality of observational studies.

Discovering Potential Mechanisms of Intervertebral Disc Disease Using Systematic Mendelian Randomization of Human Circulating Immunocytomics.

Background: Although intervertebral disc degeneration (IVDD) is a critical factor in many spine-related diseases and has an extremely high prevalence in the aging population, the potential pathogenesis remains to be clarified entirely. Immune cells have been found to perform an essential function during the onset and progression of IVDD in recent years. Therefore, we explored the association between immune cell characteristics and IVDD through Mendelian randomization (MR) analysis and further delved into the mediating role of potential metabolites.

Construction and Validation of a Risk Prediction Model for Mild Cognitive Impairment in Non-Dialysis Chronic Kidney Disease Patient.

Introduction: The aims of this study are to explore the factors affecting mild cognitive impairment in patients with chronic kidney disease (CKD) who are not undergoing dialysis and to construct and validate a nomogram risk prediction model.

Methods: Using a convenience sampling method, 383 non-dialysis CKD patients from two tertiary hospitals in Chengdu were selected between February 2023 and August 2023 to form the modeling group. The patients were divided into a mild cognitive impairment group (n = 192) and a non-mild cognitive impairment group (n = 191), and factors such as demographics, disease data, and sleep disorders were compared between the two groups.

Electroacupuncture Suppresses Oxidative Stress and Ferroptosis by Activating the mTOR/SREBP1 Pathway in Ischemic Stroke.

Ischemic stroke (IS) is one of the leading causes of death and disability worldwide. Electroacupuncture (EA) has been shown to exert a neuroprotective effect in IS. However, its specific anti-IS mechanisms remain to be fully elucidated.

l-arginine promotes angio-osteogenesis to enhance oxidative stress-inhibited bone formation by ameliorating mitophagy.

Background: Osteoporosis is one of the most common bone diseases in middle-aged and elderly populations worldwide. The development of new drugs to treat the disease is a key focus of research. Current treatments for osteoporosis are mainly directed at promoting osteoblasts and inhibiting osteoclasts.

 (Lamiaceae): A new species from Hunan, China.

This study provides detailed description of a newly-discovered Wen B. Xu, Xiao D. Li & Yan Ling Liu (Lamiaceae) species from Hunan, China.