Publications by authors named "Wen-yan Chen"

Article Synopsis
  • Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), have high rates of illness and death, and effective treatments are lacking; the gut microbiota plays a significant role in lung health through the lung-gut axis.
  • The study aimed to investigate how human umbilical cord mesenchymal cells (HUC-MSCs) can mitigate ALI caused by lipopolysaccharide (LPS) in mice and their effects on gut and lung interaction.
  • Results indicated that HUC-MSCs significantly reduced lung and ileal damage and alleviated pulmonary edema, suggesting their potential as a therapeutic option for ALI.
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Article Synopsis
  • The study investigates the need for more accurate thrombus biomarkers to diagnose venous thromboembolism (VTE) due to the limitations of D-dimer specificity.
  • Plasma samples from low-risk and high-risk groups were analyzed using mass spectrometry, identifying 371 proteins, with 30 showing significant differences in expression.
  • Among these, von Willebrand factor (VWF) levels were notably higher in the high-risk group, indicating its potential as a biomarker for thrombus in orthopedic surgery patients.
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In this study, three polysaccharides (BGPs: BGPs-Z21, BGPs-Z23, and BGPs-Z31) were successively extracted from barley (Hordeum vulgare L.) grasses (BG) at different growth stages, including seedling (Z21), tillering (Z23), and stem elongation (Z31). The effects of in vitro simulated saliva-gastrointestinal digestion on the physicochemical characteristics and biological activities of BGPs were investigated and compared.

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Despite N6-methyladenosine (mA) is functionally important in various biological processes, its role in the underlying regulatory mechanism in TNBC are lacking. In this study, we investigate the pathological role and the underlying mechanism of the mA methylated RNA level and its major methyltransferase METTL3 in the TNBC progression. We found that the mA methylated RNA was dramatically decreased in TNBC tissues and cell lines.

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Objective: To explore the protective effect of electroacupuncture (EA) on hepatic ischemia-reperfusion injury (HIRI) and the expression of high mobility group protein 1 (HMGB1) in liver tissues in rats.

Methods: A total of 40 male SD rats were randomly divided into 4 groups, namely sham control, HIRI model, "Ganshu"(BL18) -"Yanglingquan"(GB34) and non-acupoint group, with 10 rats in each group. The HIRI model was induced by blocking the arteries, veins and bile ducts supplying the middle and left lobes of the liver for 1 h, and reperfusion for 4 h to induce an area of about 70% HIRI.

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Different fertilization regimes can substantially influence soil fungal community composition, yet fewer studies try to control for the effects of nitrogen input. Here, we investigated the impact of fertilization with equal nitrogen upon soil properties and soil fungal diversity and community composition in the North China Plain in a long-term field experiment. Long-term (32 years) fertilization regimes were applied with equal amounts of nitrogen: no chemical fertilizer or organic manure; chemical fertilization only; organic manure fertilization only, and; combination of 1/2 chemical fertilizer and 1/2 organic manure.

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To clarify phylogenetic relationships amongst , and in , we examined detailed morphological characters and performed phylogenetic analyses of a concatenated dataset, based on the ITS, LSU, and DNA sequences of fungal specimens in China. Four species of nectria-related fungi were identified, i.e.

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To better evaluate the toxicity of tannery and textile effluents from various emission stages, the research attempted battery of toxicological bioassays and toxicological indices. The bioassays employed Microtox test, zebra fish embryo-larval test and algae (Chlorella vulgaris) test. Meanwhile, toxicological indices including Toxicity Unit (TU), Average Toxicity (AvTx), Toxic Print (TxPr), Most Sensitive Test (MST) and Potential Ecotoxic Effects Probe (PEEP) were applied.

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Aim: The aim of this study was to explore the genes and pathways involved in the aggressive breast cancer cells.

Methods: The gene expression profiles of GSE40057, including four aggressive breast cell lines and six less aggressive cell lines, were downloaded from the Gene Expression Omnibus (GEO) database. The gene differential expression analysis was carried out with limma software with the method of Bayes for multiple tests.

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