Targeted Inhibitory Effect of Nasopharyngeal Carcinoma Cells by Hre.Grp78 Chimeric Promoter Regulating Fusion Gene .

Objective: To construct plasmids with Hre.Grp78 chimeric promoter regulating fusion gene and elaborate the effects of overexpressed on nasopharyngeal carcinoma cells.

Methods: Four plasmids were constructed, including pcDNA3.

Numb inhibits epithelial-mesenchymal transition via RBP-Jκ-dependent Notch1/PTEN/FAK signaling pathway in tongue cancer.

Background: Oral cancer has been estimated as the sixth most frequent solid cancer all over the world, in which tongue squamous cell carcinoma (TSCC) is the most common type of oral cancers. However, the mechanism of TSCC metastasizing to lymph node and distant sites has not been completely understood.

Methods: In this study, RT-qPCR method was used to detect the mRNA level of Numb, PTEN and Notch1 genes, as well as EMT-associated genes.

[Surgical management for residual or recurrent diseases in the neck after radiotherapy in nasopharyngeal carcinoma].

Objective: To investigate the surgical managements for residual or recurrent diseases in the neck after radiotherapy in nasopharyngeal carcinoma.

Methods: Seventy-eight cases of neck masses (39 cases for unilateral residual diseases, 9 for bilateral residual diseases and 30 for recurrent diseases) after radiotherapy in nasopharyngeal carcinoma who were treated surgically between January 1990 and December 2005 were retrospectively analyzed. There were 56 males and 22 females.

[Management of thyroid goiters invading mediastinum and thoracic cavity].

Objective: To investigate the diagnosis and treatments of thyroid goiters invading mediastinum and thoracic cavity.

Methods: Seventy-eight cases of thyroid goiters invading mediastinum and thoracic cavity and undergoing surgery from 1995 to 2005 were reviewed. There were 22 males and 56 females and their age ranged from 45 years to 78 years with a median age of 59 years.

[Free anterolateral thigh flap for repairing the defects of oral cavity and maxillofacial].

Objective: To investigate the outcomes following the tumor resection of oral cavity and maxillofacial and reconstruction with free anterolateral thigh flaps (ALT).

Methods: Thirty one patients underwent ALT reconstruction following the tumor resection from Dec. 2004 to Dec.