[Treatment strategies for pediatric patients with primary cardiac tumors].

Objective: To analyze the experience of treatment strategies for pediatric patients with primary cardiac tumors.

Methods: The clinical data of 27 patients with primary cardiac tumors which detected by echocardiography from May 1999 to May 2009 was analyzed retrospectively. There were 20 male and 7 female patients, aged from 24 d to 12.

Development of mechanical circulatory support devices in China.

Myocardial dysfunction leading to low cardiac output syndrome is a common clinical pathophysiological state. Currently, the use of mechanical circulatory support (MCS) is an essential aspect of the treatment of patients with cardiac failure. Several groups in China are engaged in the design and development of MCS devices.

Arterial switch operation with coronary arteries from a single sinus in infants.

Background: The implantation of a coronary artery (CA) is critical for the arterial switch operation (ASO) done to treat complete transposition of the great arteries (TGA). Coronary artery abnormalities are risk factors for both early and late mortality after surgery. In this study, the methodology and effects of ASO surgery with coronary arteries from a single sinus were evaluated.

Use of the lecompte procedure for ventriculoarterial connection abnormalities in infants and children with congenital heart diseases.

Background: The Lecompte (REV) procedure is used to correct abnormal ventriculoarterial connections in patients with congenital heart diseases; it avoids the need for an extracardiac conduit for pulmonary outflow tract reconstruction. The present study aimed to investigate effectiveness and criteria of the REV procedure in children with abnormal ventriculoarterial connections.

Methods: Thirty-eight children (mean age, (2.

[Individualized surgical management of pulmonary atresia with intact ventricular septum].

Objective: To delineate individualized surgical management strategy for the optimal management of pulmonary atresia with intact ventricular septum (PA/IVS).

Methods: Between 1997 to 2005, 52 consecutive patients with PA/IVS, 31 male and 21 female, aged 2-9, divided into 2 groups according if right ventricle-dependent coronary circulation (RVDCC) existed, underwent individualized surgical treatment. The patients in Group I (with: RVDCC, n = 6) underwent single ventricle repair.

Surgical experience of coarctation of the aorta in infants and young children.

We evaluated the effectiveness of surgical treatment for coarctation of the aorta in infants and young children, based on our experience over 7 years. From March 1999 to December 2005, 168 cases of coarctation of the aorta in patients aged 21 days to 3 years were treated by end-to-end, extended end-to-end, or extended end-to-side ascending aorta and aortic arch anastomosis. The mortality rate was 0.

[Analysis surgical results of 113 patients with complete transposition of the great arteries].

Objective: To review and analysis the surgical results of 113 arteries Switch operations.

Methods: One hundred and thirteen patients had been repaired by arterial Switch operation from January 2001 to December 2005. There were 60 patients with transposition of the great arteries and intact ventricular septum (TGA/IVS), 53 patients with transposition of great arteries and ventricular septal defect (TGA/VSD).

Surgical treatment of persistent fifth aortic arch associated with interrupted aortic arch.

This study describes two cases of the rare congenital anomaly, persistent fifth aortic arch. Both cases involve boys (1 at 9 years of age and another at 7 months of age). To detect persistent fifth aortic arch with interrupted aortic arch, the following methods were used: echocardiogram, angiocardiography, and magnetic resonance imaging.

Left ventricular assist device for pediatric postcardiotomy cardiac failure.

Children with postcardiotomy heart failure who are unresponsive to maximal medical management have limited options for survival. Short-term mechanical circulatory support, such as with extracorporeal membrane oxygenation and ventricular assist devices, has assumed an expanding role in the care of these patients by providing a bridge to recovery. This report describes the use of left ventricular assist devices with centrifugal pumps in five pediatric cases (weight <15 kg) with postcardiotomy heart failure.

Seven years' experience of pediatric cardiopulmonary bypass: 8685 cases in Shanghai Children's Medical Center.

Herein we report our 7-year-experience of cardiopulmonary bypass. Between April 1, 1999, and December 31, 2005, 8685 children with congenital heart disease underwent cardiopulmonary bypass in Shanghai Children's Medical Center. The number of cases increased every year, and the number of patients younger than 1 year or weighing <10 kg also increased.

[Arterial switch operation for transposition of the great arteries and double outlet of right ventricle with subpulmonary ventricular septum defect].

Objective: To summarize the clinical experience on the arterial switch operation for complex congenital heart disease in recent 3 years in our hospital.

Methods: Sixty-one patients with complex congenital heart disease received by arterial switch operation from Jan 2000 to May 2003. There were 26 patients with transposition of the great arteries and intact ventricular septum (TGA-IVS), 19 patients with transposition of the great arteries and ventricular septal defect (TGA-VSD) and 16 patients with double outlet of right ventricle with subpulmonary ventricular septum defect (Taussig-Bing).

Lung perfusion with oxygenated blood during aortic clamping prevents lung injury.

To evaluate the protective effect of continuous pulmonary perfusion with oxygenated blood during aortic crossclamping, 12 mixed-breed piglets (7-12 kg) were placed on cardiopulmonary bypass for 130 minutes. An experiment group of 6 (group E) had continuous pulmonary perfusion with oxygenated blood during cardiopulmonary bypass, while the other 6 served as controls (group C). Pulmonary function was measured at the beginning and end of cardiopulmonary bypass and one hour later.

Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytes.

To solve the problem of immune incompatibility, nuclear transplantation has been envisaged as a means to produce cells or tissues for human autologous transplantation. Here we have derived embryonic stem cells by the transfer of human somatic nuclei into rabbit oocytes. The number of blastocysts that developed from the fused nuclear transfer was comparable among nuclear donors at ages of 5, 42, 52 and 60 years, and nuclear transfer (NT) embryonic stem cells (ntES cells) were subsequently derived from each of the four age groups.