Publications by authors named "Wen-xia Du"
[3, 4- dinitro-furazan-based oxidation furazan acute and subchronic toxicity studies].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
March 2013
Objective: To study the 3, 4- dinitro-furazan-based oxidation furazan (DNTF) of sub-acute toxicity and chronic toxicity, to determine the acute toxicity classification DNTF, the nature of toxic effects and major target organ for the development provide the basis for occupational exposure limits.
Methods: ( 1) Acute toxicity: The oral gavage method once infected, symptoms of poisoning of animals observed to calculate the LD50DNTF and 95% confidence limits. ( 2) sub-chronic experiment: selection of 96 healthy SD rats were randomly divided into four groups, doses of 25, 56.
[Teratogenicity of 3, 4 two furazan-based oxidation furazan in rats].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
September 2012
Objective: To study the teratogenicity of new high-energy compounds, 3, 4 two furazan-based oxidation furazan (DNTF) and the impact on human health, occupational exposure limits were provided for the following research.
Methods: Pregnant SD rats were randomly divided into five groups by Standard teratogenicity test, including three dose groups (5.0, 15.
[Study on mutagenicity and teratogenicity of ammonium dinitramide].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
November 2011
Article Synopsis
- The study aimed to evaluate the mutagenic and teratogenic effects of ammonium dinitramide (ADN) using various toxicity tests.
- Results from the Ames assay indicated ADN was not mutagenic at low doses, but higher doses led to increased micronucleus rates in mice, suggesting potential mutagenicity.
- Teratogenic assessments revealed higher rates of fetal malformations and survival issues in mice exposed to higher doses of ADN, implying ADN has teratogenic effects.
[Study on acute and subchronic toxicity of ammonium dinitramide].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
November 2011
Article Synopsis
- - The study investigates the toxicity effects of ammonium dinitramide (ADN) over different exposure durations (acute, subacute, and subchronic) to identify affected organs and toxicity levels.
- - Oral toxicity tests on mice and rats revealed an LDx of about 569 mg/kg and 617 mg/kg respectively, indicating low-level acute toxicity, with liver issues showing significant adverse effects at mid-range doses.
- - Findings indicate that exposure to 30.8 mg/kg ADN showed no negative effects, confirming the liver as the primary target organ for toxicity at higher doses.
[Research and determination of occupational exposure limits of nitroguanidine in air of working places].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
May 2010