Publications by authors named "Wen-qiong Xiu"
This study aims to investigate the characteristics of genomic variation of pandemic A/H1N1/2009 influenza virus isolated in Fujian Province, China. Complete genome sequence analysis was performed on 14 strains of pandemic A/H1N1/2009 influenza virus isolated from Fujian during 2009-2012. All virus strains were typical low-pathogenic influenza viruses, with resistance to amantadine and sensitivity to neuraminidase inhibitors.
View Article and Find Full Text PDFWU polyomavirus (WUPyV), a new member of the genus Polyomavirus in the family Polyomaviridae, is recently found in patients with respiratory tract infections. In our study, the complete genome of the two WUPyV isolates (FZ18, FZTF) were sequenced and deposited in GenBank (accession nos. FJ890981, FJ890982).
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- The study focused on the genetic and epidemic traits of influenza A (H3N2) viruses in Fujian Province, China, from 1996 to 2004, using phylogenetic analysis of HA1 gene sequences.
- Researchers found that mutations in the HA1 gene led to significant antigenic drift in the viruses over eight flu seasons, with key changes occurring at specific antibody binding sites.
- The findings suggest the importance of ongoing monitoring for mutations in HA1 to track H3 isolates as the influenza virus evolves, particularly in South Asia.
We introduced 38 single-point amino acid changes into the hemagglutinin (HA) protein of the reassortmented A/Duck/Mongolia/54/01 (H5N2) strain by a PCR random mutation method. The percentage of amino acid changes on the HA domain that did not abrogate hemadsorption activity was calculated to be 89%. Changes in the amino acids of the HA2 domain were observed to be about half of those in the HA1 domain of these mutants.
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