Publications by authors named "Wen-long Lu"
Scaling up quantum dots to two-dimensional (2D) arrays is a crucial step for advancing semiconductor quantum computation. However, maintaining excellent tunability of quantum dot parameters, including both nearest-neighbor and next-nearest-neighbor couplings, during 2D scaling is challenging, particularly for silicon quantum dots due to their relatively small size. Here, we present a highly controllable and interconnected 2D quantum dot array in planar silicon, demonstrating independent control over electron fillings and the tunnel couplings of nearest-neighbor dots.
View Article and Find Full Text PDFObjective: To investigate the protective effect and possible mechanisms of vitamin B 6 against renal injury in patients with sepsis. Methods: A total of 128 patients with sepsis who met the entry criteria in multiple centers were randomly divided into experimental (intravenous vitamin B 6 therapy) and control (intravenous 0.9% sodium chloride therapy) groups based on usual care.
View Article and Find Full Text PDFAims: This study aims to analyse the worldwide trends in hypertensive heart disease (HHD) mortality and associations with age, period, and birth cohort and predict the future burden of HHD deaths.
Methods And Results: Mortality estimates were obtained from Global Burden of Disease 2019 study. We used age-period-cohort (APC) model to examine the age, period, and cohort effects on HHD mortality between 1990 and 2019.
Article Synopsis
- * The synthesized compounds showed varying levels of effectiveness against wild-type HIV-1, with some exhibiting strong potency and selectivity as reverse transcriptase inhibitors, especially compound 4d, which was particularly effective against both wild-type and several mutant strains of HIV-1.
- * Additional analyses included assessing the structure-activity relationships of the compounds, performing molecular modeling to investigate how DPAPYs bind to HIV-1 reverse transcriptase, and predicting their
An aptamer-Fe modified nanoparticle for lactate oxidation and tumor photodynamic therapy.
Colloids Surf B Biointerfaces
April 2018
Article Synopsis
- The study focuses on creating a nanoparticle called Mn-D@BPFe-A that targets cancer by converting lactate into pyruvate through a light-induced chemical reaction.
- This nanoparticle not only helps in reducing lactate levels in cancer tissues but also inhibits key proteins associated with tumor growth, specifically HIF-1α and Glut-1.
- The findings suggest that using this modified nanoparticle could be an effective method for phototherapy in cancer treatment, as it disrupts the energy production in cancer cells by targeting their mitochondria.
Hypoxia promotes not only the metastasis of tumors but also therapeutic resistance. Photosensitizer-mediated consumption of O during photodynamic therapy (PDT) reinforces tumor hypoxia. Herein, a light-dependent attenuator of a hypoxic environment is reported for accurate MRI and phototherapy of hypoxic cancer.
View Article and Find Full Text PDFA mitochondria targeting Mn nanoassembly of BODIPY for LDH-A, mitochondria modulated therapy and bimodal imaging of cancer.
Colloids Surf B Biointerfaces
November 2016
Article Synopsis
- * The study developed a fluorescent manganese(II) nanoparticle called PEG-Mn-BDA, which acts as both a fluorescent imaging agent and MRI contrast agent for cancer cells.
- * PEG-Mn-BDA effectively inhibits LDH-A, disrupts mitochondrial function, increases harmful reactive oxygen species (ROS), and promotes cancer cell death, showing promising results in both laboratory tests and in a mouse model of liver cancer.
Study on the interaction of Fe(III) complex of BODIPY appended di(picolyl)amine with water and HeLa cells.
Spectrochim Acta A Mol Biomol Spectrosc
December 2015
The iron complex [(m-BDA)FeCl3] (Fe1) (m-BDA=8-[di(2-picolyl)amine-3-benzyl]-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene) was characterized by spectroscopic methods. The emission intensity of Fe1 is weaker than that of m-BDA due to the electrostatic interaction between the Fe(III) ion and m-BDA. However, the coordination of water with the central Fe(III) ion in Fe1 changed metal-ligand charge transfer, thus the quenched emission at 509 nm was recovered.
View Article and Find Full Text PDF[Effects of land use type on spatiotemporal distribution of soil nutrients in Dianchi watershed, Yunnan Province of Southwest China].
Ying Yong Sheng Tai Xue Bao
October 2012
Surface soil samples were monthly collected from six land use types (abandoned greenhouse field, forest land, sloped farmland, table land, flat vegetable land and greenhouse field) in Dianchi watershed of Yunnan to determine the soil pH and the contents of soil organic matter (OM), total nitrogen (TN), and total phosphorus (TP), aimed to understand the effects of different land use types on the spatiotemporal distribution of the soil nutrients. The soil pH, SOM, TN and TP, contents, and soil C/N differed significantly with soil land use types. The soil pH was in the order of abandoned greenhouse field > flat vegetable land > greenhouse field > table land > sloped farmland > forest land; the OM content was in the sequence of abandoned greenhouse field > flat vegetable land > greenhouse field > sloped farmland > forest land > table land; the TN content was in the order of greenhouse field > flat vegetable land > abandoned greenhouse field > sloped farmland > table land > forest land; the TP content was in the order of flat vegetable field > greenhouse field > abandoned greenhouse field > sloped farmland > table land > forest land; and the C/N ratio was in the sequence of forest land > sloped farmland > flat vegetable plot > table land > abandoned greenhouse field > greenhouse field.
View Article and Find Full Text PDFObjective: A quantitative method was developed by gradient elution for the determination of notoginsenoside R1, ginsenoside Rg1, ginsenoside Re and ginsenoside Rb1 in different positions of Panax Notoginseng by HPLC. The content of 4 kinds saponins in different positions of Panax Notoginseng were compared.
Methods: The different positions of Panax notoginseng (including root, rhizome, branch root, leaf, flower) were extracted with methanol.