[Effects of Microplastics on Soil NO Emission and Nitrogen Transformations from Tropical Agricultural Soils].

A widespread concern had been there regarding soil ecological and environmental problems caused by microplastic pollution in agricultural soils. A controlled laboratory incubation experiment was performed to examine the effects of different types of microplastics on soil properties, NO emissions, and nitrogen （N） transformations in tropical arable soils from a pepper-corn cropping system in Hainan Province. Three treatments were done： soil without microplastics （CK） and soil amended with 5% of polyethylene （PE） or with 5% of polybutylene adipate co-terephthalate （PBAT）.

Clinicopathological characteristics and typing of multilocular cystic renal neoplasm of low malignant potential.

Background: Up until now, no research has been reported on the association between the clinical growth rate of multilocular cystic renal neoplasm of low malignant potential (MCRNLMP) and computed tomography (CT) imaging characteristics. Our study sought to examine the correlation between them, with the objective of distinguishing unique features of MCRNLMP from renal cysts and exploring effective management strategies.

Aim: To investigate optimal management strategies of MCRNLMP.

Time alignment quantum illumination based on single real-time coincidence counting.

We propose and demonstrate an improved quantum illumination protocol based on the time correlation of twin photons, for the high signal-to-noise ratio (SNR) of target detection and signal reconstruction in the strong noise environment. The Hong-Ou-Mandel (HOM) interferometer is applied after the spontaneous parametric down-conversion (SPDC) process to construct a probing twin-beam in which the photon times are precisely aligned between the beams. At the radar receiver, we put forward a single real-time coincidence counting (SRCC) method on a series of time slices to reconstruct the probe signals of pulse radar and calculate the SNR advantages against the conventional pulse radar, as well as the quantum illumination (QI) protocol.

[Short-term responses of foliar multi-element stoichiometry and nutrient resorption of slash pine to N addition in subtropical China].

We conducted a field experiment with three levels of N addition (0, 40 and 120 kg N·hm·a) in a Pinus elliottii plantation in subtropical China and collected green and senesced needles of P. elliottii at the peak (July) and the end (October) of each growing season in 2014 and 2015 for clarifying effects of nitrogen additions on concentrations of nine elements (C, N, P, K, Ca, Mg, Al, Fe and Mn) in the green and senesced needles and their corresponding resorption efficiency and resorption proficiency. Our results showed that N addition had positive effects on concentrations of N, Al and Mn, negative effects on the P concentration and the Ca concentration in 2014, and neutral effects on concentrations of C, K, Mg and Fe in green needles.

Design of potent B-Raf inhibitors by multiple copy simulation search strategy.

B-Raf kinase is a vital intermedium in the mitogen-activated protein kinase (MAPK) signaling pathway, which transforms extracellular signals into cellular mechanisms. Mutations in this kinase, for instance, the most common V600E mutation, can lead to the ERK signaling pathologically activated and hence cause severe diseases such as somatic tumors. So far, the development of B-Raf inhibitors has made remarkable progress.

[Effects of nitrogen addition on available nitrogen content and acidification in cold-temperate coniferous forest soil in the growing season].

Based on a low-level and multi-form N addition control experiment, this study took cold-temperate coniferous forest in Daxing'an Ling as the research object. After long-term and continuous nitrogen addition in situ, the available nitrogen (NH4(+) -N & NO3(-) -N) contents and pH values of the soil (0-10 cm) were measured in the early growing season (May) and the peak growing season (August) in 2010, 2012 and 2013. The results showed that, the available nitrogen in the early and peak growing seasons was mainly NH4(+) -N which accounted for over 96% of the inorganic nitrogen content, while the content of NO3(-) -N was very low.

The imprinted H19 gene regulates human placental trophoblast cell proliferation via encoding miR-675 that targets Nodal Modulator 1 (NOMO1).

Preeclampsia is a pregnancy-specific syndrome mainly characterized by hypertensive disorder and proteinuria after gestational weeks 20. So far the etiology of preeclampsia remains unclear. We previously reported that preeclamptic placentas exhibited decreased mRNA expression and hypermethylation in promoter region of the paternally imprinted H19 gene compared with normal placentas.

Detection of global DNA methylation and paternally imprinted H19 gene methylation in preeclamptic placentas.

Preeclampsia (PE) is a severe hypertensive disorder associated with pregnancy; despite substantial research effort in the past several years, the etiology of PE is still unclear. The role of epigenetic factors in the etiology of PE, including DNA methylation, has been poorly characterized. In the present study, we investigated global DNA methylation as well as DNA methylation of the paternally imprinted H19 gene in preeclamptic placentas.

Prostasin regulates human placental trophoblast cell proliferation via the epidermal growth factor receptor signaling pathway.

Background: Prostasin is a glycosylphosphatidylinositol-anchored extracellular serine protease with a role in epidermal growth factor receptor (EGFR) signal modulation. EGFR signaling has been shown to be important for regulating cytotrophoblast (CT) cell proliferation in human placenta. We investigated the impact of prostasin expression regulation on this cellular function as well as the molecular mechanisms involved in human cytotrophoblastic cells.

[DOT1: a distinct class of histone lysine methyltransferase].

Lysine methylation is an important covalent modification of histone and has fundamental and divers roles in biological processes including regulation of chromatin structure dynamics and gene expression. Recently, a distinct class of histone lysine methyltransferase DOT1 was found to methylate histone H3 lysine79 (H3K79) residue, which is located on the accessible face of the core nucleosome. The DOT1 proteins do not contain a SET domain, a conserved sequence motif found in all previously characterized histone H3 lysine methyltransferases that act on the histone N-termianl tail.