The GLCCI1 rs37973 variant and the efficacy of inhaled corticosteroids in the treatment of asthma: A meta-analysis.

Objective: This study investigated the relationship between the glucocorticoid-induced transcript 1 (GLCCI1) gene variant and the degree of improvement in lung function with inhaled corticosteroids (ICS).

Methods: We searched the PubMed, Embase, Cochrane Library, CBM, CNKI and Wanfang databases to obtain studies on the GLCCI1 rs37973 variant and the efficacy of ICS in asthma.

Results: The overall meta-analysis showed that patients with the GG phenotype (mutant homozygotes) exhibited significantly smaller forced expiratory volume in 1 sec (FEV1) change than patients with the AG phenotype (mutant heterozygous) (MD = -0.

Theoretical Insights into the Electron Capture Behavior of H₂SO₄···N₂O Complex: A DFT and Molecular Dynamics Study.

Both sulfuric acid (H₂SO₄) and nitrous oxide (N₂O) play a central role in the atmospheric chemistry in regulating the global environment and climate changes. In this study, the interaction behavior between H₂SO₄ and N₂O before and after electron capture has been explored using the density functional theory (DFT) method as well as molecular dynamics simulation. The intermolecular interactions have been characterized by atoms in molecules (AIM), natural bond orbital (NBO), and reduced density gradient (RDG) analyses, respectively.

Dissociative electron attachments to ethanol and acetaldehyde: A combined experimental and simulation study.

Dissociation dynamics of the temporary negative ions of ethanol and acetaldehyde formed by the low-energy electron attachments is investigated by using the anion velocity map imaging technique and ab initio molecular dynamics simulations. The momentum images of the dominant fragments O(-)/OH(-) and CH3 (-) are recorded, indicating the low kinetic energies of O(-)/OH(-) for ethanol while the low and high kinetic energy distributions of O(-) ions for acetaldehyde. The CH3 (-) image for acetaldehyde also shows the low kinetic energy.

Ab initio molecular dynamics simulation study of dissociative electron attachment to dialanine conformers.

Dissociative electron attachment (DEA) processes of six low-lying conformers (1-6) of dialanine in the gas phase are investigated by using ab initio molecular dynamics simulations. The incoming electron is captured and primarily occupies the virtual molecular orbital π*, which is followed by the different dissociation processes. The electron attachments to conformers 1 and 2 having the stronger N-H···N and O-H···O intramolecular hydrogen bonds do not lead to fragmentations, but two different backbone bonds are broken in the DEAs to conformers 3 (or 4) and 6, respectively.

Three-dimensional finite element analysis and comparison of a new intramedullary fixation with interlocking intramedullary nail.

This study was set to introduce a new intramedullary fixation, explore its biomechanical properties, and provide guidance for further biomechanical experiments. With the help of CT scans and finite element modeling software, finite element model was established for a new intramedullary fixation and intramedullary nailing of femoral shaft fractures in a volunteer adult. By finite element analysis software ANSYS 10.

18F-FDG PET/CT-related metabolic parameters and their value in early prediction of chemotherapy response in a VX2 tumor model.

Objective: This study acquired fluorine-18-deoxyglucose (FDG) kinetic parameters prior and subsequent to cisplatin chemotherapy so as to define the optimal parameters for early prediction of chemotherapy response.

Methods: A total of 12 non-tumor-bearing rabbits were used to obtain noninvasive input function, five VX2 tumor-bearing rabbits were used for validation and 32 tumor-bearing rabbits underwent 4 mg kg(-1) cisplatin chemotherapy. Dynamic FDG PET/CT was performed at pretherapy, Day 0, Day 1, Day 7 and Day 14 after cisplatin administration.