Preliminary study of the effect of FK506 nanospheric-suspension eye drops on rejection of penetrating keratoplasty.

Objective: The aim of this study was to investigate the effect of a topical FK506 nanospheric suspension in a rat model of penetrating keratoplasty.

Methods: FK506 nanospheres were prepared by using a biodegradable poly (lactic-co-glycolic acid) copolymer (PLGA). Its distribution in the eye and blood after a single instillation was examined in rabbits.

[The pharmacokinetics of FK506 and its nanoparticles in aqueous humor of rabbits].

Objective: To investigate the pharmacokinetics of FK506 and its nanoparticles in aqueous humor of rabbits applied with eye drops or subconjunctiva injections.

Methods: 42 New Zealand albino rabbits were divided into 2 groups. (1) Nanoparticle solution containing 10 microg FK506 was injected into subconjunctiva or dropped on conjunctival sac of rabbits (68 eyes in 34 cases).

[Dry eye in graft-versus-host disease].

Objective: To investigate patients who had ocular presentations after allogeneic hematopoietic stem cell transplantation.

Methods: The eyes of 20 patients of leukemia who had undergone allogeneic hematopoietic stem cell transplantation were examined. The ocular surface of these patients was examined by slit-lamp.