Publications by authors named "Wen-jun Sun"

Skyrmions, a stable topological vectorial textures characteristic with skyrmionic number, hold promise for advanced applications in information storage and transmission. While the dynamic motion control of skyrmions has been realized with various techniques in magnetics and optics, the manipulation of acoustic skyrmion has not been done. Here, the propagation and control of acoustic skyrmion along a chain of metastructures are shown.

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Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer, has a poor prognosis and limited access to efficient targeted treatments. Chronic unpredictable mild stress (CUMS) is highly risk factor for TNBC occurrence and development. Type X collagen (COL10A1), a crucial protein component of the extracellular matrix, ranks second among all aberrantly expressed genes in TNBC, and it is significantly up-regulated under CUMS.

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In this paper, we use a pair of self-resonating subwavelength spoof plasmonic structures to achieve remote non-radiative terahertz wireless power transfer, while nearly without affecting the electromagnetic environment of free space around the structure. The resonating frequency and quality factor of the magnetic dipole mode supported by the spoof plasmonic structures can be freely tuned by tailoring the geometric structure. By putting the weak source and detector into the self-resonating structures, we can find that the effective non-radiative terahertz power transferring distance can reach several hundred times the radius of the structures.

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The mechanical environment is important for tumorigenesis and progression. Tumor cells can sense mechanical signals by mechanosensitive receptors, and these mechanical signals can be converted to biochemical signals to regulate cell behaviors, such as cell differentiation, proliferation, migration, apoptosis, and drug resistance. Here, we summarized the effects of the mechanical microenvironment on breast cancer cell activity, and mechanotransduction mechanism from cellular microenvironment to cell membrane, and finally to the nucleus, and also relative mechanosensitive proteins, ion channels, and signaling pathways were elaborated, therefore the mechanical signal could be transduced to biochemical or molecular signal.

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Article Synopsis
  • Esculetin (ELT) is a well-known coumarin with strong antioxidant properties but has low solubility and absorption issues.
  • To enhance its solubility, researchers created a cocrystal of ELT using nicotinamide (NAM), which has good water solubility and can boost ELT's antioxidant effects.
  • The study found that this cocrystal significantly improved ELT's solubility and bioavailability, also showing enhanced antioxidant activity and potential liver protection in rat experiments.
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Background: Most studies of the gut-brain axis have focused on bacteria; little is known about commensal fungi. Children and adolescents with depression were reported to have gut bacterial microbiota dysbiosis, but the role of the mycobiota has not been evaluated.

Methods: Faecal samples were obtained from 145 children and adolescents with depression and 110 age- and gender-matched healthy controls.

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UV/peroxymonosulfate (UV/PMS) advanced oxidation process has attracted significant attention for removal of micropollutants in water. However, during practical water treatment applications, the PMS treatment must be performed before the UV treatment to achieve full contact. In this study, sulfamethoxazole (SMX) was selected as the target micropollutant.

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The mechanism underlying the biological effects caused by an extremely low-frequency electromagnetic field (ELF-EMF) is still unclear. Previously, we found that L-type calcium channel and sphingosine kinase 1 (SK1) were involved in 50-Hz MF exposure-induced cell proliferation. In the present study, the role of intracellular Ca and signal molecules related to SK1 in cell proliferation induced by 50-Hz MF was investigated in human amniotic epithelial (FL) cells.

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Article Synopsis
  • Premenstrual dysphoric disorder (PMDD) affects about 5% of women and challenges treatment due to its varied symptoms and unclear genetic causes.
  • A study used genomic sequencing to identify copy number variations (CNVs) in patients, leading to two distinct groups correlated with different clinical presentations of PMDD, achieving 89% consistency.
  • The research found that these CNV features could effectively classify PMDD types with high accuracy, supporting the idea that genetics play a significant role in PMDD diagnosis and etiology.
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Objective: This study aimed to investigate community residents' awareness of basic life support (BLS) and their willingness to attempt rescue.

Methods: From October to December 2020, in the communities of Nantong City, a stratified three-stage random sampling method was adopted to select residents from 12 neighborhood committees over the age of 18 with whom to conduct a cross-sectional questionnaire survey. A self-designed questionnaire was adopted, the contents of which included the general situation of the respondent, knowledge, attitude, and behavior in relation to BLS; the Cronbach's α coefficient of the questionnaire was 0.

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Objective: To observe the effects of electroacupuncture (EA) on the body weight, disease progression and the expression of heat shock protein 70 (HSP70) in lumbar spinal cord of amyotrophic lateral sclerosis (ALS) mice, so as to explore the mechanism of EA on treating ALS.

Methods: Eighteen ALS transgenic SOD1 mice were randomly divided into model, EA and medication groups, with 6 mice in each group, and six C57BL/6J mice were used as the normal group. Mice in the EA group received EA at "Quchi"(LI11)-"Hegu"(LI4), "Zusanli"(ST36)- "Sanyinjiao"(SP6), 30 min/time, 5 times/week, for 8 weeks.

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Purpose: This study aimed to examine the cross-sectional and longitudinal associations of three walking parameters (frequency, duration, and intensity) with overall mental health in older adults.

Methods: A cross-sectional survey was conducted in 2014 with 1255 community-dwelling older adults aged 65 years and older in Taipei, Taiwan. Among them, 408 participants completed the one-year follow-up survey in 2015.

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High-throughput lipidomics technology was used to explore the potential therapeutic targets and mechanism of action of gelanxinning capsule on rat model with coronary heart disease (CHD). This study attempts to provide a novel method to interpret the molecular mechanism of traditional medicine. The lipid markers of CHD were determined by full-scan analysis based on ultra-performance liquid chromatography-high-definition mass spectrometry.

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Peracetic acid (PAA) has attracted growing attention as an alternative oxidant and disinfectant in wastewater treatment due to the increased demand to reduce chlorine usage and control disinfection byproducts (DBPs). These applications have stimulated new investigations on PAA-based advanced oxidation processes (AOPs), which can enhance water disinfection and remove micropollutants. The purpose of this review is to conduct a comprehensive analysis of scientific information and experimental data reported in recent years on the applications of PAA-based AOPs for the removal of chemical and microbiological micropollutants from water and wastewater.

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Article Synopsis
  • Silver nanoparticle-decorated zinc oxide (Ag-ZnO) nanowires were synthesized using chemical vapour deposition and magnetron sputtering methods, showing uniform distribution of Ag nanoparticles on ZnO.
  • The room temperature photoluminescence (RTPL) analysis indicated two strong emission peaks in the visible region for the Ag-ZnO nanowires, surpassing those of unmodified ZnO, with detailed mechanisms discussed.
  • Investigations into the nonlinear optical properties revealed behaviors like self-focusing nonlinearity and good two-photon absorption, suggesting Ag-ZnO nanowires are promising for future nonlinear optical device applications.
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In order to investigate the third-order nonlinear optical properties of InN thin film, the sample was deposited on sapphire substrates by reactive RF magnetron sputtering. The prepared samples with a hexagonal wurtzite structure were confirmed by both X-ray diffraction (XRD) and scanning electron microscope (SEM). The optical absorption spectrum of the prepared samples was measured by a double beam UV/Visible spectrophotometer.

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Objective: To establish a high-performance liquid chromatography-tandem mass spectrometry (HPLC-ESI-MS) method for simultaneous quantitative analysis of different ceramide species in cells.

Methods: The analysis was performed on an Agilent 1290 HPLC system with a ZORBAX Eclipse XDB-C8 (150.0 mm × 2.

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Metabolomics can provide an opportunity to develop the systematic analysis of the metabolites in biological samples and has been increasingly applied to discovering and identifying biomarkers and perturbed pathways. It enables us to better understand the metabolic pathways which can clarify the mechanism of traditional Chinese medicines (TCM). Yinchenhao (YCH, Artemisia annua L), a famous TCM plant, has been used clinically for more than a thousand years to relieve liver diseases in Asia, and its mechanisms are not still completely clear.

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Objective: To study the use of data mining techniques in analyzing the syndrome discipline of generalized anxiety disorder (GAD).

Methods: From August 1, 2009 to July 31, 2010, 705 patients with GAD in 10 hospitals of Beijing were investigated over one year. Data mining techniques, such as Bayes net and cluster analysis, were used to analyze the syndrome discipline of GAD.

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Objective: To study the effects of 50-Hz extremely low frequency electromagnetic field (ELF-EMF) exposure on the pH of the adult male semen and the motoricity and motoricity parameters of spermatozoa.

Methods: Healthy adult male fresh semen was exposed to a 50-Hz EMF at 0.4 mT for 15, 30 and 60 min, respectively.

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Synopsis of recent research by authors named "Wen-jun Sun"

  • - Wen-Jun Sun's recent research encompasses a diverse range of topics, including the manipulation of acoustic skyrmions for advanced materials applications, as demonstrated in his study on skyrmionic mode coupling in subwavelength metastructures.
  • - His work on triple-negative breast cancer reveals the significant role of type X collagen in tumor progression, emphasizing potential therapeutic targets through mechanistic understanding of molecular pathways influenced by chronic unpredictable mild stress.
  • - Sun has also contributed to innovative technologies such as remote terahertz wireless power transfer using spoof plasmonic structures, and examined the interplay between gut microbiota and mental health in adolescents, highlighting the influence of altered interkingdom networks in depression.