Frontiers and hotspots in anxiety disorders: A bibliometric analysis from 2004 to 2024.

Objective: This study aimed to analyze research on anxiety disorders using VOSviewer and CiteSpace to identify research hotspots and future directions.

Methods: We conduct ed a comprehensive search on the Web of Science Core Collection (WoSCC) for relevant studies about anxiety disorders published within the past two decades (from 2004 to 2024). VOSviewer and CiteSpace were mainly used to analyze the authors, institutions, countries, publishing journals, reference co-citation patterns, keyword co-occurrence, keyword clustering, and other aspects to construct a knowledge atlas.

High-Performance Turn-On Fluorescent Metal-Organic Framework for Detecting Trace Water in Organic Solvents Based on the Excited-State Intramolecular Proton Transfer Mechanism.

Simple, fast, and sensitive detection of trace water in organic solvents is an urgent requirement for chemical industries. Herein, combining the unusual excited-state intramolecular proton transfer (ESIPT) mechanism with the effective strategy of pore space partition, for the first time, we construct a powerful fluorescent metal-organic framework (SNNU-301) probe with excellent water stability. The SNNU-301 probe shows a remarkable performance for turn-on ESIPT-based fluorescence response to water in nine common organic solvents, exhibiting wide linear ranges, low limit of detection values, and ultrafast response, especially in dimethyl sulfoxide (0-5.

Safety of the 15-valent pneumococcal conjugate vaccine: A phase I clinical trial.

To evaluate the safety of the 15-valent pneumococcal conjugate vaccine (PCV15 (by LvZhu & Co. Ltd)) in healthy infants aged 2 months (minimum to 6 weeks) and 3 months old. This phase I clinical trial enrolled 80 subjects in Laishui County, Hebei Province, China.

Coinfections in hospitalized patients with severe fever with thrombocytopenia syndrome: A retrospective study.

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease with a high case fatality rate. Few studies have been performed on bacterial or fungal coinfections or the effect of antibiotic therapy. A retrospective, observational study was performed to assess the prevalence of bacterial and fungal coinfections in patients hospitalized for SFTSV infection.

A New Molecular Recognition Concept: Multiple Hydrogen Bonds and Their Optically Triggered Proton Transfer in Confined Metal-Organic Frameworks for Superior Sensing Element.

We report a new sensing mechanism based on an indium-dihydroxyterephthalic acid metal-organic framework (MOF, SNNU-153), in which the spatially fitted analyte-MOF hydrogen-bond (H-bond) formation provides selective recognition while the analyte-H-bond assisted excited-state intramolecular proton transfer (ESIPT) and the resulting ratiometric emission act as a superior signal transducer with ultrafast response. The synergy of ESIPT signal transduction and confined MOF pore enables the SNNU-153 sensor selectively sensing hydrazine even among nitrogen-containing hydride analogs such as NH, NHOH, and (Me)NNH. The key of H-bond and associated ESIPT was further counter evidenced by an indium-2,5-dimethoxyterephthalic acid MOF (SNNU-152), where the hydroxyl protons were removed by methylation, showing near inertness to NH.

Design of two isoreticular Cd-biphenyltetracarboxylate frameworks for dye adsorption, separation and photocatalytic degradation.

Two novel isoreticular cadmium metal-organic frameworks (MOFs) with the framework formula of [Cd(BPTC)(solvent)] (HBPTC = 3,3',5,5'-biphenyltetracarboxylic acid) have been constructed under diverse reaction conditions and characterized by single crystal X-ray diffraction, PXRD, IR and TGA. The neutral 3D frameworks of 1 and 2 with one-dimensional (1D) rhombic channels exhibit both distinct uptake and good selectivity for cationic methylene blue (MB) dye molecules. The adsorption capacity and adsorption kinetic constant of 2 are greater than those of 1, showing the importance of porosity and pore size during the adsorption.

Tuning of valence States, bonding types, hierarchical structures, and physical properties in copper/halide/isonicotinate system.

Seven cupric halide coordination polymers, namely [Cu5(OH)3Br3(ina)4] (1), [Cu5(OH)3Cl3(ina)4] (2), [Cu2(OH)Cl(ina)2] (3), [Cu3(OH)2Cl2(ina)2]·2H2O (4), [Cu3(OH)2Br2(ina)2]·2H2O (5), [Cu2Cl2(ina)2(H2O)2] (6), [Cu2Cl(ina)2(gca)(H2O)] (7), cupric complex templated cuprous halide [Cu(II)(Me-ina)2(H2O)][Cu(I)5Br7] (8), and organic templated cuprous halide Me2-ina[Cu2Br3] (9) (Hina = isonicotinic acid), were prepared from the starting materials of cupric halide and Hina via fine-tuning solvothermal reactions. According to valence states of copper, 1-7 are copper(II) complexes, 8 is a mixed-valent Cu(I,II) complex, while 9 is a Cu(I) compound. According to bonding types of halides, nine complexes can be classified as three types: complexes 1-3 include only normal X-Cu bond (X = halide); complexes 4-7 include normal X-Cu bond and X···Cu weak bond; complexes 8 and 9 include normal X-Cu bond and X···H-C halogen hydrogen bonds.

The first ionothermal synthesis of a 3D ferroelectric metal-organic framework with colossal dielectric constant.

A novel 3D (4,6)-connected topological architecture, obtained under ionothermal conditions by using 1-ethyl-3-methyl imidazolium bromide ([EMI]Br) as solvent and structure-directing agent, presents a non-centrosymmetric polar packing arrangement showing an interesting ferroelectric property.

[Ursodeoxycholic acid inhibits hepatocyte-like cell apoptosis by down-regulating the expressions of Bax and Caspase-3].

Objective: To investigate the mechanism of ursodeoxycholic acid (UDCA) in hepatocyte apoptosis using differentiated hepatocytes derived from bone marrow mesenchymal cells.

Methods: Rat bone marrow mesenchymal cell was induced into mature hepatocytes in vitro and then treated with PBS (Cont), deoxycholic acid (DCA), DCA plus UDCA (U + D) or UDCA alone (UDCA). Cell apoptosis was detected by Hoechst staining and Caspase-3 activity measurement.

[Case-control study of risk factors in cholangiocarcinoma].

Objective: To investigate the risk factors of intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC).

Methods: The clinicopathological data of 190 patients with cholangiocarcinomas (61 ICC and 129 ECC) diagnosed and treated in the Peking Union Medical College Hospital between 1998 and 2008 were collected. The clinicopathological data of 380 matched healthy controls were also collected.

[Expression of hepatocyte-enriched transcriptional factors during the differentiation of bone marrow mesenchymal stem cell-derived hepatocytes].

Objective: To study the expression and distribution of hepatocyte-enriched transcriptional factors during the differentiation of hepatocyte by rat bone marrow stem cells in vitro.

Methods: Mesenchymal stem cells were isolated from rat bone marrow and induced into mature hepatocyte in vitro. The mRNA expression levels of hepatocyte nuclear factor 4 alpha (HNF4 alpha), CCAAT enhancer binding protein (C/EBP) alpha and beta were compared between induced and non-induced cultures using semi-quantitative reverse transcription-polymerase chain reaction.