Publications by authors named "Wen-jiao Zeng"
Hepatocyte apoptosis plays important roles in both the removal of external microorganisms and the occurrence and development of liver diseases. Different conditions, such as virus infection, fatty liver disease, hepatic ischemia reperfusion, and drug-induced liver injury, are accompanied by hepatocyte apoptosis. This review summarizes recent research on the mechanism of hepatocyte apoptosis involving the classical extrinsic and intrinsic apoptotic pathways, endoplasmic reticulum stress, and oxidative stress-induced apoptosis.
View Article and Find Full Text PDFBackground And Aim: Traditional pathological scoring systems for liver fibrosis progression are predominantly based on the description of architectural changes with no consideration of the amount of collagen fiber deposition. Our purpose was to explore a true histological standard in accordance with the liver stiffness measured by point shear wave elastography (PSWE) in patients with chronic hepatitis B.
Methods: A total of 78 patients with liver neoplasms underwent liver stiffness measurements with PSWE as well as biochemical investigations within 3 days before partial hepatectomy.
[Real-time elastography for quantitative assessment of liver fibrosis in a rat model].
Zhonghua Gan Zang Bing Za Zhi
May 2012
Article Synopsis
- The study aimed to evaluate the effectiveness of real-time elastography for measuring liver fibrosis in a rat model, specifically using 70 male Wistar rats with induced liver injury and 10 saline-injected controls.
- After administering dimethylnitrosamine (DMN), rats were sacrificed at various time points for pathology analysis, while elastography was used to measure liver fibrosis index and low-strain area ratios.
- The results indicated a significant correlation between elastography measurements and liver fibrosis stages, with both the liver fibrosis index and low-strain area increasing as fibrosis severity escalated, suggesting that real-time elastography could be a reliable tool for assessing liver health.
Aim: To study the relationship between prognosis and pathological characteristics, proliferating cell nuclear antigen labeling index (PCNA-LI) and DNA index (DI) in patients with moderately differentiated hepatocellular carcinoma(HCC).
Methods: 51 cases of moderately differentiated HCC were analyzed with respect to the relation between their clinical follow-up data and pathological characteristics. Meanwhile, PCNA-LI of HCC cells was detected by immunohistochemistry assay and DI was measured by Feulgen staining and automatic image analysis technique.