Tunable electronic structure and excellent catalytic properties of transition-metal-doped BeN monolayer.

The electronic properties and OER catalytic activity of pristine BeN monolayers and single-transition-metal-doped BeN monolayers (TM@BeN) were systematically investigated using density functional theory. Among all the types of TM@BeN analyzed, Fe@BeN was determined to exhibit the best OER activity, with an overpotential of 0.33 V, and to display excellent metallic conductivity.

Enhanced optical absorption in two-dimensional Ruddlesden-Popper (CHCHNH)PbI perovskites biaxial strain and surface doping.

Two-dimensional Ruddlesden-Popper (2D RP) perovskites can form layered protective materials using long organic cations as "barrier" caps, which is expected to solve the problem of instability of perovskites in the working environment. In this work, we systematically studied the 2D Ruddlesden-Popper (CHCHNH)PbI hybrid perovskites using density functional theory. The results reveal that the 2D (CHCHNH)PbI perovskites are semiconductors with band gaps of 2.

Development and validation of an MRI-based radiomics nomogram for distinguishing Warthin's tumour from pleomorphic adenomas of the parotid gland.

Objective：: Preoperative differentiation between parotid Warthin's tumor (WT) and pleomorphic adenoma (PMA) is crucial for treatment decisions. The purpose of this study was to establish and validate an MRI-based radiomics nomogram for preoperative differentiation between WT and PMA.

Methods And Materials: A total of 127 patients with histological diagnosis of WT or PMA from two clinical centres were enrolled in training set ( = 75; WT = 34, PMA = 41) and external test set ( = 52; WT = 24, PMA = 28).

[Analysis of a Pollution Process in the Beijing-Tianjin-Hebei Region Based on Satellite and Surface Observations].

The air pollution control of the Beijing-Tianjin-Hebei region (BTH region) is gradually moving toward regional joint mode. Remote sensing technology can be used to realize real-time dynamic monitoring over a wide range of space and ground-based monitoring can obtain accurate point information. Combining satellite with ground-based data, the formation and dissipation of pollution can be traced in three dimensions.

[Estimation of Coal Consumption and the Emission of Related Contaminants in the Plain Area Around Beijing During 2015-2017].

Spatial distribution of bungalow areas in the plain area of Beijing was interpreted using high resolution remote sensing images from 2015-2017, and data for the nearby surrounding areas was added in 2017. The bungalow development areas were then refined by a combination of field sampling and imagery interpretation. A statistical model was developed to estimate the coal consumption in bungalow areas based on statistical records of the developed areas.

[Spatial and Temporal Distribution Characteristics and Fugitive Dust Emission of Building Sites in Beijing].

Because of the continuous expansion of the city and the evacuation of non-core functions, the city pattern of Beijing has gradually changed in recent years. Based on many construction projects, building sites are widely distributed within the city. Therefore, fugitive dust emission is an important factor affecting the air quality in Beijing.

A potential material for hydrogen storage: a Li decorated graphitic-CN monolayer.

Motivated by recent experimental developments of graphitic-CN (g-CN) sheets, we investigate the suitability of hydrogen storage on Li decorated g-CN via first-principles calculations. We find that the binding energies of Li atoms are very large, ranging from 2.70 to 4.

Cystatin C Shifts APP Processing from Amyloid-β Production towards Non-Amyloidgenic Pathway in Brain Endothelial Cells.

Amyloid-β (Aβ), the major component of neuritic plaques in Alzheimer's disease (AD), is derived from sequential proteolytic cleavage of amyloid protein precursor (APP) by secretases. In this study, we found that cystatin C (CysC), a natural cysteine protease inhibitor, is able to reduce Aβ40 secretion in human brain microvascular endothelial cells (HBMEC). The CysC-induced Aβ40 reduction was caused by degradation of β-secretase BACE1 through the ubiquitin/proteasome pathway.

Two-dimensional interlocked pentagonal bilayer ice: how do water molecules form a hydrogen bonding network?

The plethora of ice structures observed both in bulk and under nanoscale confinement reflects the extraordinary ability of water molecules to form diverse forms of hydrogen bonding networks. An ideal hydrogen bonding network of water should satisfy three requirements: (1) four hydrogen bonds connected with every water molecule, (2) nearly linear hydrogen bonds, and (3) tetrahedral configuration for the four hydrogen bonds around an O atom. However, under nanoscale confinement, some of the three requirements have to be unmet, and the selection of the specific requirement(s) leads to different types of hydrogen bonding structures.

Association between IL-27 2905T/G genotypes and the risk and survival of cervical cancer: a case-control study.

Background: Interleukin-27 (IL-27) has been recognized as a pleiotropic cytokine with both pro- and anti-inflammatory properties.

Patients And Methods: A case-control study was conducted to investigate the possible associations of IL-27 gene polymorphisms with susceptibility to cervical cancer and clinical outcome.

Results: Our results suggested that the IL-27 2905T/G was significantly associated with a decreased risk of cervical cancer.

[Distribution Characteristics and Source Analysis of Dustfall Trace Elements During Winter in Beijing].

The dustfall content is one of the evaluation indexes of atmospheric pollution. Trace elements especially heavy metals in dustfall can lead to risks to ecological environment and human health. In order to study the distribution characteristics of trace elements, heavy metals pollution and their sources in winter atmospheric dust, 49 dustfall samples were collected in Beijing City and nearby during November 2013 to March 2014.

Highly confined water: two-dimensional ice, amorphous ice, and clathrate hydrates.

Understanding phase behavior of highly confined water, ice, amorphous ice, and clathrate hydrates (or gas hydrates), not only enriches our view of phase transitions and structures of quasi-two-dimensional (Q2D) solids not seen in the bulk phases but also has important implications for diverse phenomena at the intersection between physical chemistry, cell biology, chemical engineering, and nanoscience. Relevant examples include, among others, boundary lubrication in nanofluidic and lab-on-a-chip devices, synthesis of antifreeze proteins for ice-growth inhibition, rapid cooling of biological suspensions or quenching emulsified water under high pressure, and storage of H2 and CO2 in gas hydrates. Classical molecular simulation (MD) is an indispensable tool to explore states and properties of highly confined water and ice.

[Spatial distribution of inhalable particulate and association with respiratory disease in Beijing City].

Inhalable particulate has become the premier pollutant of Beijing, which has enormous influence on the environmental quality of the city and health of the residents. Inhalable particle pollutants (particulate matter of 0.3, 0.

[Analysis of medication with hypertension by different glucose tolerance status].

Objective: To analyze the combination of hypertension and the use of antihypertensive drugs by different glucose tolerance status.

Methods: Matched case-control design was used to sample the subjects from the population for the prevalence of diabetes mellitus and metabolism syndrome from 2007 to 2008. There were 3 groups including normal glucose tolerance (NGT, n = 2124), impaired glucose regulation (IGR, n = 2162) and diabetes (DM, n = 2470).

Highly selective adsorption of methanol in carbon nanotubes immersed in methanol-water solution.

The systems of open-ended carbon nanotubes (CNTs) immersed in methanol-water solution are studied by molecular dynamics simulations. For the (6,6) CNT, nearly pure methanol is found to preferentially occupy interior space of the CNT. Even when the mass fraction (MF) of methanol in bulk solution is as low as 1%, the methanol MF within the CNT is still more than 90%.

[Correlates of cognitive impairment in patients with leukoaraiosis by magnetic resonance spectroscopy].

Objective: To explore the pathological changes in patients with leukoaraiosis (LA) by magnetic resonance spectroscopy (MRS) and examine its relationship with cognitive function.

Methods: Twenty-three LA patients and 23 age and gender-matched healthy subjects were recruited from the Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University between August 2010 and November 2010. All participants underwent the neuropsychological tests.

Chemiluminescence determination of gemifloxacin based on diperiodatoargentate (III)-sulphuric acid reaction in a micellar medium.

A novel flow-injection chemiluminescence (FI-CL) analysis method for the determination of gemifloxacin in the presence of cetyltrimethylammonium bromide (CTAB) surfactant micelles is described. Strong CL signal was generated during the reaction of gemifloxacin with diperiodatoargentate (III) in a sulfuric acid medium sensitized by CTAB. Under optimum experimental conditions, the CL intensity was linearly related to the concentration of gemifloxacin from 1.

[Serum uric acid level and related clinical features in neuromyelitis optica].

Objective: To investigate serum uric acid (UA) levels and related clinical characteristics of neuromyelitis optica (NMO).

Methods: The serum uric acid levels were measured in 65 patients with NMO, compared to control groups which were 76 cases with multiple sclerosis (MS), 126 cases with cerebral vascular diseases (CVD) and 130 healthy controls (HC). The disability severity in NMO was assessed by the Expanded Disability Status Scale (EDSS).

[Relation between c-erbB1, c-erbB2, MAPK expression and resistance to tamoxifen in breast cancer cells in vitro].

Objective: To study the growth regulation pathway and the mechanism of acquired resistance to tamoxifen (TAM) in breast cancer cells.

Methods: TAM was used to induce wild-type MCF-7 human breast cancer cell line and establish a tamoxifen-resistant (TAM-R) cell line. RT-PCR, Western blot and immuocytochemical techniques were used to detect and compare mRNA and protein of c-erbB1, cerbB2, c-erbB3, c-erbB4 in wild-type MCF-7 and TAM-R MCF-7 cell lines.

[Relationship between hepatic insulin resistance and the expression of genes involved in hepatic glucose output].

Objective: To study the relationship between hepatic insulin resistance induced by high fat diet and the expression of genes involving hepatic glucose output.

Methods: Normal 8-week-old male SD rats were randomly divided into two groups, i.e, normal chow group (NC, n = 10) and high fat diet group (HF, n = 10).

[Effect on late-stage mammary cancer treated by endocrinotherapy or chemotherapy combined with pingxiao capsule].

Objective: To explore the action of pingxiao capsules (PXC) and its significance in the treatment of late stage mammary cancer (LSMC).

Methods: One hundred and forty-two LSMC patients were randomized into four groups: the two single treated groups treated by endocrinotherapy (ET) alone (n = 27) and by chemotherapy alone (n=44) respectively, and the two PXC combined treated groups treated with PXC plus endocrinotherapy (n=27) or chemotherapy (n=44). The remission rate and progression time (TTP) of disease, the survival time and quality of life (QOL) of patients, and the adverse reaction were compared between the single treated groups and the combined treated groups.

[Relationship between adipose phosphoenolpyruvate carboxykinase and occurrence and reversion of insulin resistance].

Objective: To investigate the relationship between the expression of phosphoenolpyruvate carboxykinase (PEPCK) gene and insulin resistance induced by high-fat diet and the effect of rosiglitazone, a thiazolidinedione drug.

Methods: Sixty-three normal 8-week-old male SD rats were randomly divided into 2 groups: short-term group, n = 33, to be fed for 8 weeks and re-divide into 3 equal subgroups: standard chow diet subgroup (NC subgroup fed with standard chow diet), high-fat diet subgroup (HF subgroup, to be fed with lard), and high-fat diet with rosiglitazone subgroup (HF + rosiglitazone subgroup); and long-term group, n = 30, to be fed for 28 weeks, and re-divided into 3 corresponding 3 subgroups: By the end of experiment, serum samples were collected to examine the blood glucose (BG), triglyceride (TG) and free fatty acid (FFA). At the end of the experiment the rats were killed and the visceral adipose tissue was taken out to be weighed, and the liver, muscle, and epididymis were isolated.

[The effect of high fat feeding and rosiglitazone intervention on pancreatic alpha cell in rats].

Objective: To observe the effect of high-fat diet and rosiglitazone intervention on the function of pancreatic alpha cell of SD rats.

Methods: 36 normal male SD rats, 8-week old, were randomly divided into 3 groups i.e.

[Effects of rosiglitazone and metformin on insulin resistance in high-fat diet rats].

Objective: To observe the effects of rosiglitazone and metformin in rats on insulin resistance induced by high-fat diet.

Methods: Normal 8-week old male SD rats were divided into four groups. They were normal chow group (NC, n = 11), high-fat diet (HF, n = 11), metformin-treated (HF + Met, n = 11) and rosiglitazone-treated group (HF + Ros, n = 11).