Fluorescent Carbon Dioxide-Based Polycarbonates Probe for Rapid Detection of Aniline in the Environment and Its Biomarkers in Urine.

Aniline compounds, as a class of widely used but highly toxic chemical raw materials, are increasingly being released and accumulated in the environment, posing serious threats to environmental safety and human health. Therefore, developing detection methods for aniline compounds is of particular significance. Herein, we synthesized the fluorescent third monomer cyano-stilbene epoxide M and ternary copolymerized it with carbon dioxide (CO) and propylene oxide (PO) to synthesize carbon dioxide-based polycarbonate (PPCM) with fluorescence recognition functions, as well as excellent performance, for the first time.

Regulation on air temperature by residential area morphology: A case study in Xuzhou City, China.

Due to woodlands and farmlands being replaced by residential areas in cities, continuous urbanization resulting in frequent urban heat island effects, especially in summer when high temperature seriously threaten health and lives of citizens. Although scientists realized that reasonable residential area morphology could effectively regulate air temperature and improve microclimate, it is lack of air temperature regulation-oriented specifications and requirements on morphology of residential areas. In this study, we used three types of morphological parameters of 15 residential areas in Xuzhou City and air temperature data via field investigation to analyze air temperature regulation caused by residential area morphology.

Nitro-oleic acid ameliorates erectile dysfunction in a streptozotocin-induced rat model of diabetes by inhibiting oxidative stress and apoptosis and activating the NO/cGMP pathway.

The major vascular complications associated with diabetes make the management of diabetic mellitus erectile dysfunction (DMED) a challenging endeavor. Notable factors contributing to DMED include oxidative stress, nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway activation, and apoptosis, while nitro-oleic acid (NO 2 -OA) has been shown to be beneficial in treating these aspects of this condition. We, herein, investigated the effects and possible mechanisms of NO 2 -OA on erectile function as assessed in a streptozotocin-induced rat model of diabetes.

Prognosis and clinical characteristics of patients with 3β-hydroxy-Δ5-C27-steroid dehydrogenase deficiency diagnosed in childhood: A systematic review of the literature.

Objectives: 3β-hydroxy-Δ5-C27-steroid dehydrogenase deficiency is a rare autosomal recessive condition. So far fewer than 100 cases have been reported and the factors affecting the prognosis are not yet established. The objective of this study is to explore a possible prediction of the outcome of this rare condition.

Functional Expression of Transient Receptor Potential and Piezo1 Channels in Cultured Interstitial Cells of Human-Bladder Lamina Propria.

The interstitial cells in bladder lamina propria (LP-ICs) are believed to be involved in sensing/afferent signaling in bladder mucosa. Transient receptor potential (TRP) cation channels act as mechano- or chemo-sensors and may underlie some of the sensing function of bladder LP-ICs. We aimed to investigate the molecular and functional expression of TRP channels implicated in bladder sensory function and Piezo1/Piezo2 channels in cultured LP-ICs of the human bladder.

SLC12A8 plays a key role in bladder cancer progression and EMT.

Bladder cancer is the most common malignant tumor of the urinary system. The intention of the present research is to explore the prognostic value and biological function of solute carrier family 12 member 8 (SLC12A8) in bladder cancer. The analysis based on the TCGA and ONCOMINE database revealed that the expression of SLC12A8 in bladder cancer was notably increased compared with the normal group.

A New Dinuclear Cobalt Complex for Copolymerization of CO and Propylene Oxide: High Activity and Selectivity.

Based on the ligand HSalen-8Bu (salen-), a new dinuclear cobalt complex (salen-)[Co(III)TFA] (salen- = 3,5-di--butylsalicylaldehyde-3,3'-diaminobiphenylamine; TFA = trifluoroacetic acid) has been firstly synthesized and characterized. It shows high catalytic activity for the copolymerization of propylene oxide (PO) and carbon dioxide (CO), yielding regioregular poly(propylene carbonate) (PPC) with little generation of propylene carbonate (PC) by-product. It has been found that (salen-)[Co(III)TFA] shows higher activity at milder conditions, generating a polymer with maximum Mn of 293 kg/mol and a narrow molecular weight distribution PDI of 1.

Enhancing the energy barrier by replacing the counterions in two holmium(iii)-pentagonal bipyramidal single-ion magnets.

Based on a phosphine oxide ligand, HMPA (hexamethylphosphoric triamide), two mononuclear Ho-pentagonal bipyramidal complexes were synthesized with the formulas [Ho(HMPA)(HO)]Cl·2HMPA·2HO (1) and [Ho(HMPA)(HO)]Br·2HMPA (2). Single-crystal X-ray diffraction results show that all Ho ions in both the two complexes are hepta-coordinated and are located in pentagonal bipyramidal {HoO7} coordination polyhedrons constructed by two axial HMPA ligands and five equatorial water molecules. However, due to the employment of different halide ions as counterions, the second coordination sphere surrounding each [Ho(HMPA)(HO)] moiety is different in the two complexes: in 1, three Cl ions, one water molecule and one HMPA ligand; in 2, three Br ions and two HMPA ligands.

Synthesis and Optimization of Ti/Li/Al Ternary Layered Double Hydroxides for Efficient Photocatalytic Reduction of CO to CH.

A series of Ti/Li/Al ternary layered double hydroxides (TiLiAl-LDHs) with different Ti:Li:Al molar ratios were prepared by a coprecipitation method for photocatalytic CO reduction. It was demonstrated that the contents of anions between the layers of Ti/Li/Al-LDHs greatly determined the photocatalytic activity for CO reduction. With Ti:Li:Al molar ratios optimized to be 1:3:2, the largest contents of [Formula: see text] anion and hydroxyl group were obtained for the TiLiAl-LDHs sample, which exhibited the highest photocatalytic activity for CO reduction, with CH production rate achieving 1.

A new air- and moisture-stable pentagonal-bipyramidal Dy single-ion magnet based on the HMPA ligand.

Based on the HMPA ligand, a new air- and moisture-stable pentagonal-bipyramidal DyIII single-ion magnet [Dy(HMPA)2(H2O)5]2·Br6·2HMPA·2H2O (1) was prepared and characterized. Single-crystal X-ray tests showed the two crystallographically independent DyIII ions located in a pentagonal-bipyramidal coordination sphere with strong axial HMPA ligands and weak equatorial water molecules relating to strong unaxial anisotropy. Direct-current and alternating-current magnetic susceptibilities were measured and showed that 1 exhibited slow relaxation of magnetization up to 36 K (1000 Hz) with an energy barrier of 556 K and blocking temperature of 7 K (defined by the peak temperature of zero-field cooling data).

New Coordination Complexes Based on the 2,6-bis[1-(Phenylimino)ethyl] Pyridine Ligand: Effective Catalysts for the Synthesis of Propylene Carbonates from Carbon Dioxide and Epoxides.

We aimed to develop new effective catalysts for the synthesis of propylene carbonate from propylene oxide and carbon dioxide. A kind of MCl coordination complex was fabricated based on the chelating tridentate ligand 2,6-bis[1-(phenylimino)ethyl] pyridine (). The obtained products were characterized by elemental analysis, infrared spectroscopy, ultraviolet spectroscopy, thermogravimetric analysis, and single-crystal X-ray diffraction.

[Real-time transrectal ultrasonography in seminal vesiculoscopy].

Objective: To compare three different pathways for transurethral seminal vesiculoscopy (SVS) and investigate the reliability and efficiency of transrectal ultrasonography (TRUS)-guided SVS (TRUS-SVS).

Methods: We retrospectively analyzed 90 cases of seminal vesiculoscopy conducted directly through the ejaculatory duct or prostatic utricle or under the guide of TRUS. We compared the success rate and complications among the three approaches.

Excited state dynamics of symmetric and asymmetric Cr(dpa)Cl measured using femtosecond transient absorption spectroscopy.

Herein, the excited-state dynamics of an extended metal atom chain complex, Cr(dpa)Cl (dpa = dipyridylamide), in tetrahydrofuran solution were investigated using femtosecond transient absorption spectroscopy. Upon excitation at a wavelength of 330 nm, two distinct excited-state absorption species with varied dynamics were identified and assigned to the symmetric (s-) and unsymmetric (u-) Cr(dpa)Cl. The major species is s-Cr(dpa)Cl that undergoes rapid conversion at less than 100 fs from the ligand-centred π-π* state, which is the initially accessed state, to the metal-centred d-d state and then vibrational cooling accompanying the structural relaxation at a time constant ∼2.

[Effect of human concentration nucleoside transporters 1 and multi-drug resistance protein 4 gene polymorphism on response of chronic hepatitis B to nucleoside analogues treatment].

Objective: To investigate the effect of human concentration nucleoside transporters 1 (hCNT1/ SLC28A1) and multi-drug resistance protein 4 (MRP4/ABCC4) gene polymorphism on the response of chronic hepatitis B patients to nucleoside analogues treatment.

Methods: There were 136 patients of chronic hepatitis B treated with entecavir (68) or telbivudine (68). The allele and gene frequency distributing of the four loci of hCNT1/SLC28A1 and MRP4/ABCC4 as well as the polymorphisms were detected in all patients by multiplex snapshot single base extension method.

A magnetic and conductive study on a stable defective extended cobalt atom chain.

Two pentacobalt(II) EMACs were synthesized. A pyrazine-modulated tripyridyldiamine resulted in an EMAC with fully delocalized Co-Co bonds along molecules. From a pyrazine- and naphthyridine-containing ligand, a defective cobalt linear EMAC with an 8-coordinated cobalt(II) in the center was obtained for the first time.

A coordination polymer consisting of two different one-dimensional copper(II) chains.

The title compound, catena-poly[[[diaqua(methanol-κO)copper(II)]-μ-N-(4-methylpyrimidin-2-yl-κN(1))pyrazin-2-amine-κ(2)N(1):N(4)] [[aqua(aqua/methanol-κO)(perchlorato-κO)copper(II)]-μ-N-(4-methylpyrimidin-2-yl-κN(1))pyrazin-2-amine-κ(2)N(1):N(4)] tris(perchlorate) methanol monosolvate 1.419-hydrate], {[Cu(C9H9N5)(CH3OH)(H2O)2][Cu(C9H9N5)(ClO4)(CH3OH)0.581(H2O)1.

Overexpression of human telomerase reverse transcriptase promotes the motility and invasiveness of HepG2 cells in vitro.

Recent studies have indicated that telomerase activity promotes cancer invasion and metastasis, but the underlying mechanism remains unclear. Several studies have shown that expression of exogenous human telomerase reverse transcriptase (hTERT) can promote motility and invasiveness among telomerase-negative tumor cells, and inhibition of endogenous telomerase activity can reduce invasiveness in tumor cells. However, whether overexpression of hTERT can further enhance the motility and invasiveness of telomerase‑positive tumor cells has yet to be determined.

N-(Pyrazin-2-yl)-1,8-naphthyridin-2-amine.

There are two independent mol-ecules in the asymmetric unit of the title compound, C12H9N5, in which the C-N(amine)-C angles differ slightly [129.63 (11) and 132.02 (11)°].

Bis(morpholin-4-ium) tetra-chlorido-cobalt(II).

The title compound, (C(4)H(10)NO)(2)[CoCl(4)], is an ionic compound consisting of two protonated tetra-hydro-1,4-oxazine (morpholine) cations and a [CoCl(4)](2-) dianion. The Co(II) ion is in a tetra-hedral coordination geometry. The cations exhibit chair-shaped conformations.

A novel system of artificial antigen-presenting cells efficiently stimulates Flu peptide-specific cytotoxic T cells in vitro.

Therapeutic numbers of antigen-specific cytotoxic T lymphocytes (CTLs) are key effectors in successful adoptive immunotherapy. However, efficient and reproducible methods to meet the qualification remain poor. To address this issue, we designed the artificial antigen-presenting cell (aAPC) system based on poly(lactic-co-glycolic acid) (PLGA).

Excited-state dynamics of the metal string complex Co3(dpa)4(NCS)2 from femtosecond transient absorption spectra.

Transient absorption spectroscopy is used to study the excited-state dynamics of Co(3)(dpa)(4)(NCS)(2), where dpa is the ligand di(2-pyridyl)amido. The pi pi*, charge-transfer, and d-d transition states are excited upon irradiation at wavelengths of 330, 400 and 600 nm, respectively. Similar transient spectra are observed under the experimental temporal resolution and the transient species show weak absorption.

Excited-state dynamics of metal string complex Ni3(dpa)4X2 from femtosecond transient absorption spectra.

The excited-state dynamics of Ni(3)(dpa)(4)X(2), in which dpa is the ligand di(2-pyridyl)amido and X = NCS or Cl, are investigated by transient absorption spectroscopy. The pi pi* and dd states are excited upon irradiation at wavelengths of 330 and 600 nm, respectively. Similar transient spectra are observed under the experimental temporal resolution.

New generation of metal string complexes: strengthening metal-metal interaction via naphthyridyl group modulated oligo-alpha-pyridylamido ligands.

To design new metal string complexes, several naphthyridyl group modulated oligo-alpha-pyridylamido ligands have been synthesized in the past five years. Because these ligands are less anionic than pyridylamido ligands, the resulting metal string complexes tend to form reduced mixed-valence [Ni(2)(napy)(4)](3+) dinuclear units which contain a delocalized unpaired electron and thus significantly enhance the conductance of metal string complexes. Furthermore, the asymmetric naphthyridyl group modulated oligo-alpha-pyridylamido ligands can stabilize the central heteronuclear or charge disproportionational metal frameworks, providing a plausible strategy to build inorganic molecular rectifiers.