Publications by authors named "Wen-Zhe Nie"
Article Synopsis
- * In this study, 41 derivatives of dihydroartemisinin (DHA) were synthesized, with one compound, A3, showing remarkable anti-proliferative effects against cancer cells, 16 times more potent than DHA.
- * Compound A3 works through multiple mechanisms: it regulates key protein expressions that contribute to redox imbalance, triggers ferroptosis, induces apoptosis, and effectively inhibits tumor growth in a mouse model, suggesting it could be a promising anti-cancer drug candidate.
Usnic acid has a variety of biological activities, and has been widely studied in the fields of antibacterial, immune stimulation, antiviral, antifungal, anti-inflammatory and antiparasitic. Based on this, usnic acid is used as the lead compound for structural modification. In order to enhance the biological activity and solubility of usnic acid, scholars have carried out a large number of structural modifications, and found some usnic acid derivatives to be of more potential research value.
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