Publications by authors named "Wen-Yue Zhang"

Article Synopsis
  • Researchers developed a new method for breaking S-S bonds using a Se-S dynamic exchange reaction with NaSe-disulfide.
  • This method was successfully applied to create benzothiazole derivatives, showing effective bond cleavage with lower amounts of the reagent needed.
  • The findings suggest that this metal selenide-disulfide interchange could be a useful technique for synthesizing various sulfur-containing compounds.
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Background: Ischemic stroke, a major cause of death and disability worldwide, results from reduced blood flow to the brain, leading to irreversible neuronal damage. Recent evidence suggests that ferroptosis, a form of regulated cell death, plays a critical role in the pathogenesis of ischemic stroke. Rhein, a natural anthraquinone compound, has demonstrated neuroprotective effects; However, its role in ferroptosis and the underlying mechanisms remain unclear.

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Background: Skeletal muscle abnormalities, such as muscle mass depletion (sarcopenia) and fatty infiltration of the muscle (myosteatosis), are frequent complications in cirrhotic patients scheduled for transjugular intrahepatic portosystemic shunt (TIPS).

Aim: To investigate the association and predictive value of sarcopenia and myosteatosis for overt hepatic encephalopathy (HE) and mortality after TIPS.

Methods: The records of cirrhotic patients who underwent the TIPS procedure at our hospital between January 2020 and June 2021 were retrospectively retrieved.

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  • This study explores cutaneous tuberculosis, focusing on its various types and the unclear causes behind the disease.
  • Researchers analyzed 58 isolated strains over 20 years, looking into their genomic traits, including lineage, drug resistance, and mutations linked to infection sites.
  • Results revealed that while strains from skin and lung tuberculosis were genetically similar and showed lower drug resistance in skin cases, specific gene mutations correlated strongly with infection sites, indicating more research on these SNPs is needed.
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Purpose: The proximity function is an important index in microdosimetry for describing the spatial distribution of energy, which is closely related to the biological effects of organs or tissues in the target area. In this work, the impact of parameters, such as physic models, cut-off energy, and initial energy, on the proximity function are quantitated and compared.

Methods: According to the track structure (TS) and condensed history (CH) low-energy electromagnetic models, this paper chooses a variety of Monte Carlo (Monte Carlo, MC) codes (Geant4-DNA, PHITS, and Penelope) to simulate the track structure of low-energy electrons in liquid water and evaluates the influence of the electron initial energy, cut-off energy, energy spectrum, and physical model factors on the differential proximity function.

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Two new prenylated xanthones, mangoxanthones A-B (-), together with four known compounds -, were isolated from the ethanol extract of the pericarp of . The structures of these compounds have been elucidated based on spectroscopic analysis. The analysis results of chiral HPLC revealed compounds and were scalemic mixtures respectively.

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Article Synopsis
  • - The study focused on a skin infection in an immunocompromised patient in China caused by a new type of bacteria from the Mycobacterium gordonae complex.
  • - Whole-genome sequencing revealed that some strains previously identified as M. gordonae are actually distinct species, meaning they have different evolutionary histories.
  • - The findings suggest the need for reclassification of these strains to better reflect their relationships and differences.
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Background: There is a high incidence of leprosy among house-contacts compared with the general population. We aimed to establish a predictive model using these genetic factors along with epidemiological factors to predict leprosy risk of leprosy household contacts (HHCs).

Methods: Weighted genetic risk score (wGRS) encompassing genome wide association studies (GWAS) variants and five non-genetic factors were examined in a case-control design associated with leprosy risk including 589 cases and 647 controls from leprosy HHCs.

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Background: Nonalcoholic fatty liver disease (NAFLD) has become prevalent in recent decades, especially in developed countries, and approaches for the prevention and treatment of NAFLD are not clear. The aim of this research was to analyze and summarize randomized controlled trials that investigated the effects of probiotics on NAFLD.

Methods: Seven databases (PubMed, Embase, the Web of Science, the Cochrane Library, China National Knowledge Infrastructure, Wan Fang Data, and VIP Database) were searched.

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Objectives: To investigate factors that may lead to false-positive or false-negative results in a computer-aided diagnostic system (S-Detect; Samsung Medison Co, Ltd, Seoul, Korea) for ultrasound (US) examinations of solid breast lesions.

Methods: This prospective study was approved by the Institutional Review Board of Sun Yat-sen Memorial Hospital. All patients signed and provided written informed consent before biopsy or surgery.

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Aim: To investigate clarithromycin resistance positions 2142, 2143 and 2144 of the 23SrRNA gene in Helicobacter pylori (H. pylori) by nested-allele specific primer-polymerase chain reaction (nested-ASP-PCR).

Methods: The gastric tissue and saliva samples from 99 patients with positive results of the rapid urease test (RUT) were collected.

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Flexible organic light-emitting diodes (OLEDs) are emerging as a leading technology for rollable and foldable display applications. For the development of high-performance flexible OLEDs on plastic substrate, we report a transparent nanocomposite electrode with superior mechanical, electrical, and optical properties, which is realized by integrating the nanoimprinted quasi-random photonic structures into the ultrathin metal/dielectric stack to collectively optimize the electrical conduction and light outcoupling capabilities. The resulting flexible OLEDs with green emission yield the enhanced device efficiency, reaching the maximum external quantum efficiency of 43.

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The clinical effect of electroacupuncture on depression is widely recognized. However, the signal transduction pathways and target proteins involved remain unclear. In the present study, rat models of chronic restraint stress were used to explore the mechanism by which electroacupuncture alleviates depression.

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