Publications by authors named "Wen-Ying Song"
[Effect of Actinidia chinensis planch polysaccharide on the growth and apoptosis, and p-p38 expression in human gastric cancer SGC-7901 cells].
Zhongguo Zhong Xi Yi Jie He Za Zhi
March 2014
Article Synopsis
- The study investigated how polysaccharides from Actinidia chinensis affect the growth and death of SGC-7901 gastric cancer cells.
- Results showed that different concentrations of the polysaccharides decreased cell viability over time and enhanced apoptosis, with significant changes in protein markers involved in cell death.
- The findings suggest that these polysaccharides induce apoptosis mainly through the p38MAPK pathway, which activates pro-caspase-9 and PARP, leading to cell death.
Article Synopsis
- The study examines the protective effects of a fusion protein called TAT-M9 against oxidative stress and neuronal death during acute stroke events in mouse models of cerebral ischemia.
- Researchers induced stroke in mice and treated them with TAT-M9 or control substances, evaluating outcomes such as neurological function, brain damage, and cellular apoptosis.
- Results show that TAT-M9 significantly improved neurological function, reduced brain injury, and inhibited oxidative damage by blocking certain cellular processes, suggesting its potential as a treatment for stroke.
Objective: To test the hypothesis that spinal cord protection induced by ischemic postconditioning is mediated by an increase of endogenous antioxidant enzyme activities during reperfusion phase in spinal cord.
Methods: Seventy-eight male New Zealand rabbits were randomly divided into 3 groups: Sham group (n = 18) undergoing sham operation without aortic occlusion; ischemia/reperfusion (I/R) group (n = 30) undergoing occlusion of the infrarenal abdominal aorta for 20 min, followed by reperfusion; and postconditioning (PostC) group (n = 30) undergoing occlusion of the infrarenal abdominal aorta for 20 min followed by 3 cycles of 30 s reperfusion/30 s ischemia just at the onset of reperfusion. 30 min, and 1, 3, 6, 24, and 48 h after reperfusion 5 rabbits from each group (and 3 from the Sham group) were killed with their spinal cords taken out, and spectrophotometric method was used to determine the antioxidant enzyme activity and malondialdehyde (MDA) content 6, 24, and 48 h after reperfusion motor function scoring of the hind limbs was conducted.
Objective: To investigate whether postconditioning with sevoflurane could alleviate spinal cord ischemia reperfusion injury in rabbits, and whether the beneficial effect is dependent on oxygen free radicals.
Methods: In Experiment 1, 48 male New Zealand white rabbits were randomly assigned to six groups (n=8 each). Animals in the sham group only underwent sham-operation.