Publications by authors named "Wen-Ye Zhu"
Background: Pulmonary artery (PA) aneurysms are usually diagnosed radiographically and present as small or large lesions resembling inflammation or a neoplasm on chest radiography. It has rarely been reported as an endobronchial mass.
Case Summary: We report the case of a 64-year-old man who presented with recurrent hemoptysis.
Objective: VEGF-D is a potential biomarker for lymphangioleiomyomatosis (LAM); however, its diagnostic performance has yet to be systematically studied.
Methods: We searched PubMed, EMBASE, Scopus, Web of Science, and Cochrane Library to identify primary studies on VEGF-D in relation to the diagnosis of LAM. The quality of the studies was evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2).
Association between Vitamin D Receptor Gene Polymorphisms with Childhood Temporal Lobe Epilepsy.
Int J Environ Res Public Health
October 2015
Vitamin D (VD) is implicated in multiple aspects of human physiology and vitamin D receptor (VDR) polymorphisms are associated with a variety of neuropsychiatric disorders. Although VD deficiency is highly prevalent in epilepsy patients and converging evidence indicates a role for VD in the development of epilepsy, no data is available on the possible relationship between epilepsy and genetic variations of VDR. In this study, 150 controls and 82 patients with temporal lobe epilepsy (TLE) were genotyped for five common VDR polymorphisms (Cdx-2, FokI, BsmI, ApaI and TaqI) by the polymerase chain reaction-ligase detection reaction method.
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- The study investigated the relationship between temporal lobe epilepsy and the NRG1 gene polymorphisms in a group of 73 patients and 69 controls.
- The results showed that the rs35753505 (T>C) variant was significantly associated with temporal lobe epilepsy, particularly with a higher frequency of the risk allele C in patients compared to controls.
- The significant association was observed only in males, and no links were found with other NRG1 polymorphisms tested.
Article Synopsis
- The study investigates how vitamin D, specifically calcitriol, influences neurotransmitter systems in rat brains over a 6-week period.
- Higher doses of calcitriol led to increased levels of GABA and enhanced the expression of related enzymes, suggesting a positive impact on GABAergic signaling.
- Calcitriol also raised levels of glutamate and glutamine in the prefrontal cortex and influenced the expression of enzymes involved in dopamine and serotonin metabolism, indicating potential effects on mood and cognitive functions.
The impacts of swimming exercise on hippocampal expression of neurotrophic factors in rats exposed to chronic unpredictable mild stress.
Evid Based Complement Alternat Med
December 2014
Depression is associated with stress-induced neural atrophy in limbic brain regions, whereas exercise has antidepressant effects as well as increasing hippocampal synaptic plasticity by strengthening neurogenesis, metabolism, and vascular function. A key mechanism mediating these broad benefits of exercise on the brain is induction of neurotrophic factors, which instruct downstream structural and functional changes. To systematically evaluate the potential neurotrophic factors that were involved in the antidepressive effects of exercise, in this study, we assessed the effects of swimming exercise on hippocampal mRNA expression of several classes of the growth factors (BDNF, GDNF, NGF, NT-3, FGF2, VEGF, and IGF-1) and peptides (VGF and NPY) in rats exposed to chronic unpredictable mild stress (CUMS).
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