Publications by authors named "Wen-Ye Song"
Article Synopsis
- Metformin, commonly used for type-2 diabetes, has been investigated for its effects on recovery after spinal cord injuries, with mixed results reported in studies.
- High doses and immediate administration of metformin after injury were linked to increased mortality and limited recovery, prompting the exploration of a lower dose given later (3 days post-injury).
- Findings revealed that administering a lower dose of metformin later significantly improved locomotor function and reduced inflammation at the injury site, suggesting its potential benefits for spinal cord injury recovery via anti-inflammatory and neuroprotective effects.
Stem cell transplantation, especially treatment with bone marrow mesenchymal stem cells (BMSCs), has been considered a promising therapy for the locomotor and neurological recovery of spinal cord injury (SCI) patients. However, the clinical benefits of BMSCs transplantation remain limited because of the considerably low viability and inhibitory microenvironment. In our research, low-intensity pulsed ultrasound (LIPUS), which has been widely applied to clinical applications and fundamental research, was employed to improve the properties of BMSCs.
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- The study conducted at Tianjin Medical University General Hospital analyzed medical records of traumatic spinal cord injury (TSCI) patients from 1999 to 2016, focusing on the changing causes and characteristics of these injuries over two periods (1999-2007 and 2008-2016).
- Out of 831 identified cases, key findings include a significant shift in the leading causes of TSCI: from traffic accidents dominating in the earlier period to a rise in low falls during the latter.
- Demographic data showed a male-to-female ratio of 2.9:1, with an increasing mean age of patients over time, and a notable decrease in complete tetraplegia cases, indicating potential improvements in injury management
The treatment strategies for spine fractures in patients with ankylosing spondylitis: A case report.
Medicine (Baltimore)
November 2017
Purpose: The aim of the study was to explore surgical strategies for effectively treating spine fractures in patients with ankylosing spondylitis (AS) and investigate the postoperative outcomes.
Methods: We retrospectively analyzed 9 patients with AS that was complicated by spine fractures, who underwent surgery at our spine and spinal cord clinic between 2005 and 2012. The surgical methods included posterior instrumentation and bone grafting, with or without decompression.
Background: Postdural puncture headache (PDPH), mainly resulting from the loss of cerebral spinal fluid (CSF), is a well-known iatrogenic complication of spinal anesthesia and diagnostic lumbar puncture. Spinal needles have been modified to minimize complications. Modifiable risk factors of PDPH mainly included needle size and needle shape.
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