[Clinical implication of microvasculopathy in patients post heart transplantation].

Objective: Assess the clinical implication of microvasculopathy detected by endomyocardial biopsy samples in patients post heart transplantation.

Methods: Light microscopic evaluations were performed in 278 endomyocardial biopsies harvested from 64 patients post heart transplantation for more than one year, microvasculopathy was defined as stenotic endothelial and/or medial disease.

Results: The patients with stenotic microvasculopathy were younger than those without microvasculopathy (40.

[Clinicopathologic analysis of dilated heart in cardiac transplant recipients].

Objective: To study the pathologic features of dilated heart in cardiac transplant recipients, with clinicoradiologic correlation.

Methods: Sixty recipient hearts from cardiac transplantation performed in Fuwai Hospital were analyzed by gross examination, histologic observation and electron microscopy. Clinicoradiologic correlation was available in 40 cases.

[The clinicopathological endomyocardial biopsy analysis in cardiac transplant recipients due to end-stage heart failure].

Objective: Endomyocardial biopsies from 42 (35 males and 7 females, aged 43.3 years) heart transplant recipients due to end-stage heart failure between June 2004 and January 2006 in our institute were obtained for pathological studies.

Methods: Sixteen patients underwent 1 endomyocardial biopsy (right ventricular septum) between 13 days to 5 months, 13 patients underwent second biopsy between 1.

[Effects of atenolol and metoprolol on cardiomyocyte apoptosis and related gene expression after acute myocardial infarction in rats].

Objective: To compare the beneficial effects of Atenolol and Metoprolol on cardiomyocyte apoptosis and related gene expressions after acute myocardial infarction (AMI) in rats.

Methods: AMI model was established with the ligation of anterior descending coronary artery in 251 randomly selected female SD rats. Twenty-four hours after operation, the 124 survivors were randomly assigned to AMI control group (MI group, n = 43), Atenolol group (group A, 10 mg x kg(-1) d(-1), n = 39), and Metoprolol group (group B, 20 mg x kg(-1) x d(-1), n = 42).

[Beneficial effects of carvedilol on cardiomyocyte apoptosis and bcl-2/bax expression after acute myocardial infarction an experiment with rats].

Objective: To investigate the beneficial effects of carvedilol on cardiomyocyte apoptosis and related gene expression after acute myocardial infarction (AMI).

Methods: Eighty-three female SD rats underwent ligation of left anterior descending coronary artery, and were randomly assigned to 2 groups 24 hours later: carvedilol (n = 40, 10 mg.kg(-1).

[Morphological study of severe acute respiratory syndrome (SARS)].

Objective: Seven cases of autopsy from SARS patients are studied to investigate the pathogenesis and the pathologic changes of the major organs.

Methods: Detailed gross and microscopic examination of the autopsy specimen is performed, including lung, heart, liver, kidney, spleen and lymph nodes.

Results: All of the lungs are markedly enlarged and consolidated.

[Lung pathology of severe acute respiratory syndrome].

Objective: To study the morphological features of the lungs obtained from autopsies of severe acute respiratory syndrome (SARS) patients.

Methods: Bilateral lungs from 7 patients died from SARS were carefully studied grossly and microscopically. All tissues from these cases were routinely processed and carefully studied.

[Clinical-pathological study on 10 cases of pulmonary thromboembolism].

Objective: To improve the diagnosis of pulmonary thromboembolism (PTE) by a clinical-pathological analysis of 10 cases of PTE.

Methods: Eight cases of massive and submassive (in the segmental and larger pulmonary arteries) PTE confirmed by autopsy and 2 cases of PTE who underwent surgical treatment in the past 10 years (1991 - 2001) were studied. The specimens were fixed in 10% buffered formalin, and paraffin sections cut, and stained with HE and ET + VG.