AAV-Mediated Gene Therapy Restores Hearing in Patients with DFNB9 Deafness.

Mutations in OTOFERLIN (OTOF) lead to the autosomal recessive deafness 9 (DFNB9). The efficacy of adeno-associated virus (AAV)-mediated OTOF gene replacement therapy is extensively validated in Otof-deficient mice. However, the clinical safety and efficacy of AAV-OTOF is not reported.

Detecting spatial chirp signals by Luneburg lens based transformation medium.

Gradient refractive index (GRIN) lens-based chirp signal chirpiness detection usually relies on the fractional Fourier transform (FRFT) functionality of a quadratic GRIN lens and is limited by paraxial conditions. In this paper, a non-FRFT mechanism-based chirpiness detection GRIN lens is proposed that converts the Luneburg lens' focus capacity of input plane waves to the designed lens' focusing of input chirp waves using transformation optics, and the source chirpiness can be obtained by sweeping the illumination wavelength rather than locating the focusing pulse, consequently greatly increasing the upper limit of the chirpiness detection range. The feasibility and robustness of the method are verified through numerical simulations.

A study of the genus Limnophora Robineau-Desvoidy (Diptera: Muscidae), with descriptions of six new species from China.

This paper provides the characters of genus Limnophora (Diptera: Muscidae) and a key to the Chinese species of Limnophora, six new species collected from Hainan Island of China, namely, L. brevispatula, n. sp.