Sequential treatment of anti-PD-L1 therapy prior to anti-VEGFR2 therapy contributes to more significant clinical benefits in non-small cell lung cancer.

Objective: Anti-angiogenic therapy and immune checkpoint blockade therapy are currently important treatments for non-small cell lung cancer. However, the combined use of the two therapies is controversial, and few studies have investigated the effects of different time sequences of the two therapies on treatment outcomes.

Methods: The tumor-bearing mouse model was established and the mice were divided into four groups, including AA-ICB sequence group, ICB-AA sequence group, synchronization group and the control group.

Anticancer Benefit of Metformin in Patients With Early-Stage Pancreatic Cancer: A Retrospective Cohort Study.

Epidemiologic studies have produced conflicting results on the effects of metformin on pancreatic cancer. This study aimed to observe and analyze whether metformin use is associated with better prognosis in pancreatic cancer. In this retrospective cohort study, all baseline data were retrieved from The Chinese Medicine Information Retrieval System (https://dc.

[Effects of Invasion on Soil Phosphorus Forms in the Jiaozhou Bay Wetland].

To investigate the effects of invasion on soil phosphorus(P) cycling in coastal wetlands, we selected a zone(SA zone) and mudflat zone(MF zone) in the Jiaozhou Bay as the target areas for the study. The variability of total phosphorus(TP), inorganic phosphorus(IP), and their component contents in wetland soils after invasion and their influencing factors was evaluated. The results showed that the average contents of TP(472.

Synthesis of 1-substituted phenazines as novel antichlamydial agents.

A novel series of 1-substituted phenazines - were designed and synthesized Palladium-catalyzed reactions from 1-phenazine trifluoromethanesulfonate. These phenazines showed antichlamydial activity with IC values from 1 to 10 μM. Among them, compounds and exhibited the best antichlamydial activity with IC values from 2.

[Influence of Pervious/Impervious Pattern on Runoff and Pollution in Parcel-based Catchment].

Determining the influence of pervious/impervious underlying surface pattern (composition, position, proportion, etc.) on the generation capacity of surface runoff and pollution in the urban parcel-based catchment could aid in alleviating the urban waterlogging and control non-point source pollution significantly. Landscape metrics were used to analyze the relationship between the characteristics of pervious/impervious underlying surface pattern and total runoff () and the cumulative load of dissolved pollutants () and particulate pollutants ().

[Transition of Particulate Pollutant in the Parcel-based Catchment of Sponge City].

Most sponge city constructions in China are carried out in urban parcel-based catchments, and the quality and quantity of surface runoff can be controlled by several low impact development (LID) facilities. However, there are few reports on the generation and control of urban diffuse pollution. In this study, two areas with different hardening rates were compared to analyze the load conditions during the accumulation-wash-off-transport process of particulate pollutants.

[Pollutant Transport Analysis and Source Apportionment of the Entire Non-point Source Pollution Process in Combined Sewer Systems].

A comprehensive and scientific understanding of non-point source pollutant transport pathways and source apportionment in combined sewer systems is essential for managing and improving the urban water environment. This study analyzed build-up and wash-off processes of pollutants on road surfaces and in sewers within a catchment of combined sewer systems in a typical old district in Zhuhai. Besides, source apportionment of the entire urban non-point source pollution was investigated by using the mass conservation method.

Adenosine A2A Receptor Mediates Inhibition of Synovitis and Osteoclastogenesis after Electroacupuncture in Rats with Collagen-Induced Arthritis.

Background: This study was to investigate the role of adenosine A2A receptors (A2AR) in inhibiting the effect of electroacupuncture (EA) on osteoclastogenesis in collagen-induced arthritis (CIA).

Methods: Wistar rats were divided into four groups: sham-control group, CIA-control group, CIA-EA group, and CIA-EA-SCH58261 (A2AR antagonist) group. We detected tumor necrosis factor- (TNF-), nuclear transcription factor-B (NF-B), receptor activator of NF-B ligand (RANKL), protein kinase A (PKA), and extracellular regulatory protein kinase 1/2 (ERK1/2) in peripheral blood by ELISA.

[Vertical distribution and seasonal variation of nitrogen, phosphorus elements in Spartina alterniflora wetland of Jiaozhou Bay, Shandong, China].

In order to study the vertical distribution and the seasonal variation of N and P in Spartina alterniflora wetland of Jiaozhou Bay, soil samples in S. alterniflora wetland and bare flat in April, July, September, October, November and December 2015 were collected, and TN, NH-N, TP, AP, TOC, pH, salinity and water content were tested. The average values of soil TN, NH-N, TP and AP contents in S.

Repeated Electroacupuncture Persistently Elevates Adenosine and Ameliorates Collagen-Induced Arthritis in Rats.

The aim of this paper was to investigate the effect of repeated electroacupuncture (EA) over 21 days on the adenosine concentration in peripheral blood of rats with collagen-induced arthritis (CIA). Wistar rats were divided into three groups of 6 animals each: sham-control, CIA-control, and CIA-EA. We determined the adenosine concentration in peripheral blood and assessed pathological changes of ankle joints.

[Emissions of methyl halides from coastal salt marshes: A review].

Methyl halides are the major carrier of halogens in the atmosphere, and they play an important role in tropospheric and stratospheric ozone depletion. Meanwhile, methyl halides can act as greenhouse gases in the atmosphere, and they are also environmentally significant because of their toxicity. Coastal salt marshes, the important intertidal ecosystems at the land-ocean interface, have been considered to be a large potential natural source of methyl halides.

[Research advances in methyl bromide in the ocean].

Methyl bromide is an important atmospheric trace gas, which plays significant roles in the global warming and atmospheric chemistry. The ocean plays important and complex roles in the global biogeochemical cycles of methyl bromide, not only the source of atmospheric methyl bromide, but also the sink. Therefore, developing the chemical research of the soluble methyl bromide in the ocean, will not only have a certain guiding significance to the atmospheric ozone layer protection, but also provide a theoretical basis for estimating methyl bromide's contribution to the global environmental change on global scale.

Adenosine A2A Receptors Mediate Anti-Inflammatory Effects of Electroacupuncture on Synovitis in Mice with Collagen-Induced Arthritis.

To study the role of adenosine A2A receptor (A2AR) in mediating the anti-inflammatory effect of electroacupuncture (EA) on synovitis in collagen-induced arthritis (CIA), C57BL/6 mice were divided into five treatment groups: Sham-control, CIA-control, CIA-EA, CIA-SCH58261 (A2AR antagonist), and CIA-EA-SCH58261. All mice except those in the Sham-control group were immunized with collagen II for arthritis induction. EA treatment was administered using the stomach 36 and spleen 6 points, and stimulated with a continuous rectangular wave for 30 min daily.

[Effects of acupuncture on different acupoints in combination with rehabilitation on hemiplegic muscle spasticity in hemiplegia patients].

Objective: To observe the clinical effect of hemiplegic muscle spasticity treated with acupuncture on different acupoints in combination with rehabilitation.

Methods: Ninety cases of post-stroke muscle spasticity were randomized into a corresponding and central axis acupuncture group (group A), a conventional acupuncture group (group B) and a rehabilitation group (group C), 30 cases in each one. In group A, the acupoints on the Governor Vessel were mainly selected, as well as those on Hand-Shaoyang meridian and Foot-Taiyang meridian.

[Effect of transcutaneous acupoint electrical stimulation on blood bioactive compounds involving cerebral injury during craniotomy].

Objective: To observe the effect of transcutaneous acupoint electrical stimulation (TAES) on plasma ET, CGRP and serum IL-6, S100beta during craniotomy.

Methods: Fifty patients scheduled for neurosurgery were randomly divided into TAES group (n=25) and control group (n=25). TAES (2/100 Hz, 8-12 mA) of bilateral Hegu (LI 4)-Quchi (LI 11), Zusanli (ST 36)-Sanyinjiao (SP 6) was administrated for patients of TAES group starting 30 min before anesthesia till the end of the operation.

Potential production simulation and optimal nutrient management of two hybrid rice varieties in Jinhua, Zhejiang Province, China.

Potential growth of two widely-grown hybrid rice varieties in the Jinhua district of Zhejiang Province, Shanyou63 for mid-rice and Xieyou46 for late rice, was simulated using a crop growth model of WOFOST. Parameters of the rice growth in WOFOST were calibrated through field experiments from 1999 to 2002 in Jinhua. The potential yield simulated with WOFOST was about 12 t/ha for Shanyou63 and 10 t/ha for Xieyou46, which are in good agreement with the highest recorded yield obtained in this area.

Effects of nitrogen fertilization strategies on nitrogen use efficiency in physiology, recovery, and agronomy and redistribution of dry matter accumulation and nitrogen accumulation in two typical rice cultivars in Zhejiang, China.

Field experiments were conducted in farmers' rice fields in 2001 and 2002 to study the effects of nitrogen (N) management strategies on N use efficiency in recovery (RE), agronomy (AE) and physiology (PE) and redistribution of dry matter accumulation (DMA) and nitrogen accumulation (NA) in two typical rice cultivars in Jinhua, Zhejiang Province. This study aimed mainly at identifying the possible causes of poor fertilizer N use efficiency (NUE) of rice in Zhejiang by comparing farmers' fertilizer practice (FFP) with advanced site-specific nutrient management (SSNM) and real-time N management (RTNM). The results showed that compared to FFP, SSNM and RTNM reduced DMA and NA before panicle initiation and increased DMA and NA at post-flowering.