Publications by authors named "Wen-Wen Yang"

Article Synopsis
  • - The 4f subshell electronic structure of rare earth elements gives them unique electrical, magnetic, and optical properties, making them suitable for creating molecular probes with features like long fluorescence lifetimes and strong resistance to photobleaching.
  • - Different imaging techniques offer distinct benefits but also come with limitations, and dual-modality molecular probes help overcome these issues, particularly in advanced Magnetic Resonance Imaging (MRI) applications.
  • - This review explores the uses, advantages, challenges, and current state of research on rare earth elements in four dual imaging methods (MRI/OI, MRI/PET, MRI/CT, MRI/US), aiming to guide future advancements in dual-modality molecular probes.
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Aim: To investigate the role of lipopolysaccharide (LPS) from Porphyromonas gingivalis and miR-155-5p-enriched exosomes in the formation of foam cells and the occurrence of carotid atherosclerosis (CAS).

Methods: The CAS tissue samples and plasma from the healthy control group or patients undergoing periodontitis without CAS and with CAS were collected at the Xuanwu Hospital, Capital Medical University. The expression level of miR-155-5p was evaluated by immunofluorescent analysis and qRT-PCR.

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It was a systematic review and meta-analysis that aimed to compare the efficiency and safety of robot-assisted urological surgery using both the KangDuo and da Vinci robotic systems. The PubMed, Embase, and Cochrane Library databases were searched for all papers published through September 1, 2024. The focus was on English-language papers comparing the KangDuo surgical robot and the da Vinci system in urological procedures.

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Postoperative pain management has consistently been a critical topic in the medical field, with patient-controlled intravenous analgesia (PCIA) being one of the most commonly utilized methods for postoperative analgesia. Currently, opioids remain the primary choice for PCIA in clinical practice. However, in recent years, an increasing number of studies have explored analgesic strategies aimed at reducing or eliminating the use of opioids in PCIA to mitigate the associated side effects and dependence.

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Periodontitis is a significant independent risk factor for atherosclerosis. Yet, the exact mechanism of action is still not fully understood. In this study, we investigated the effect of exosomes-miR-155-5p derived from periodontal endothelial cells on atherosclerosis in vitro and in vivo.

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Owing to their inherent flexibility and excellent biocompatibility, liquid metals (LMs) have been explored at the frontiers of clinical therapy. Herein, a LM and tanshinone IIA (TA) drugs were dispersed into sodium alginate (SA) solution by ultrasonication to prepare SA/LM/TA, which is an injectable biomaterial for stable drug release and intrapericardial injection for the treatment of myocardial infarction (MI). The SA/LM/TA has a low viscosity and can be injected smoothly using a syringe.

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This review comprehensively examines the impact of anesthesia and surgical interventions on the immune function of cancer patients postoperatively. Recent studies have shown that surgery and its accompanying anesthesia management can significantly influence immune function in cancer patients, potentially affecting their prognosis. This review synthesizes clinical studies and basic research to summarize the specific effects of anesthesia methods, drugs, postoperative analgesia, intraoperative transfusion, surgical techniques, and trauma extent on the immune function of cancer patients post-surgery.

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Objective: To assess the efficacy of Qingda Granule (QDG) in ameliorating hypertension-induced cardiac damage and investigate the underlying mechanisms involved.

Methods: Twenty spontaneously hypertensive rats (SHRs) were used to develope a hypertension-induced cardiac damage model. Another 10 Wistar Kyoto (WKY) rats were used as normotension group.

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Article Synopsis
  • - Doping polycyclic conjugated hydrocarbons with sulfur, particularly through thiophene, is gaining significance for developing new functional materials, with recent focus on thiopyran-containing helicenes.
  • - The study presents the synthesis and structural analysis of a unique double [7]helicene that features thiopyran, showing distinct propeller-shaped structures and impressive solid-state interactions.
  • - The synthesized helicene demonstrates notable deep-red to near-infrared fluorescence and favorable properties, making it a promising candidate for applications in photodynamic therapy and bioimaging, particularly through its chiral and photosensitizing abilities.
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In order to elucidate the changes in the soil fungal community and soil organic carbon components of a garden after straw and biochar application, we measured the organic carbon components and soil fungal community of the 0-15 cm soil layer in a garden, which was divided into a control group, straw treatment group, and biochar treatment group. The carbon pool management index (CPMI) was also calculated. The results showed that the diversity of the soil fungal community was decreased after straw and biochar application, and the structure of dominant fungal genera was changed in each treatment.

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Background: Previous investigations have shown a positive relationship between baseball pitching velocity and the kinetic chain involved in pitching motion. However, no study has examined the influence of finger characteristics on pitching velocity and rate of spin via a sensor-embedded baseball.

Methods: Twenty-one pitchers volunteered and were recruited for this study.

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Article Synopsis
  • * Despite ambitious plans for an independent HTA center, the initiative hasn't succeeded due to factors like inadequate collaboration, lack of organizational support, and political-economic hurdles.
  • * Enhancing the current HTA system's autonomy and fostering a supportive learning environment are essential for making informed decisions and ensuring credible assessments in Taiwan's healthcare landscape.
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The copper-modified tubular carbon nitride (CTCN) with higher specific surface area and pore volume was prepared by a simple in-situ hydrolysis and self-assembly. Increased ∼4.7-fold and ∼2.

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Visible-light-induced EDA complex-promoted ring-opening of cycloketone oxime esters to synthesise various cyanoalkylated products with -methacryloyl benzamides was developed. Various radical receptors were compatible with the current reaction system to furnish diverse heterocyclic compounds. Mechanistic analysis shows that the formation of an EDA complex was crucial to the photocatalytic strategy.

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Background: The efficacy and safety of Qingda granule (QDG) in managing blood pressure (BP) among grade 1 hypertensive patients with low-moderate risk remain uncertain.

Methods: In the randomized, double-blind, double dummy, non-inferiority and multicenter trial, 552 patients with grade 1 hypertension at low-moderate risk were assigned at a ratio of 1:1 to receive either QDG or valsartan for 4 weeks, followed up by a subsequent 4 weeks.

Results: Post-treatment, clinic systolic/diastolic BPs (SBP/DBP) were reduced by a mean change of 9.

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Health technology assessment (HTA) is a multidisciplinary process that determines the value of health technology at different points in its lifecycle. Safety issues have become more important since regulatory authorities are increasingly adopting flexible standards, processes, and evidentiary requirements for drug approval. In this article, we compared the different role of regulatory authorities and HTA agencies.

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The estimated prevalence of anti-HCV was 3.1% in Taiwan. Studies have shown iatrogenic behavior was the major transmission route.

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Introduction: Body mass index (BMI) trajectories, such as non-linear time trends and nonlinear changes in BMI with age, can provide information on the underlying temporal health patterns. The relationship between BMI trajectories and the risk of hypertension remains controversial.

Methods: PubMed, Embase, Cochrane, Scopus, and Web of Science databases were searched from their inception to January 31, 2022.

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Background: To assess the effectiveness of the nurse-led individualised self-care model on myocardial infarction (MI) patients with diabetes.

Methods: A total of 120 MI patients were enrolled from May 2020 to December 2021. The intervention group received the nurse-led individualised self-care model (n = 60), whereas the control group only received routine health education (n = 60).

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This study was designed to systematically evaluate the effects of growth factor (GF) for therapeutic angiogenesis on ischemic heart disease (IHD) by pooling the results of randomized controlled trials (RCTs). PubMed, EMBASE, and CENTRAL databases were searched from inception to October 2022. RCTs, investigating the effects of GF therapy on IHD, were included.

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Objective: This study investigated the effects of 12 weeks of specifically designed physical activity intervention on working memory and motor competence in preschool children and explored the correlation between working memory changes and motor competence changes by the intervention.

Methods: Four classes of preschool children were grouped into an intervention group and a control group. Children in the intervention group received a 12-week physical activity intervention, while children in the control group followed their daily routine as usual.

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Multiple heterohelicenes are a unique class of helical nonplanar scaffolds that have attracted great attention due to their appealing shapes, optical and electronic properties, and potential applications in chiral materials. This review describes the recent advances and challenges in the design and synthesis of representative multiple heterohelicenes with intriguing chiral properties. And the corresponding applications are also covered.

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Protein fluorescence reporting systems are of crucial importance to in-depth life science research, providing systematic labeling tools for visualization of microscopic biological activities and revolutionizing basic research. Cotton somatic cell regeneration efficiency is low, causing difficulty in cotton transformation. It is conducive to screening transgenic somatic embryo using the fluorescence reporting system.

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Consistently, the multiple heart-kidney interactions make pharmaceutical research for cardiorenal syndrome difficult and complex. Guanxinning Injection (GXN) has been reported to provide unique advantage for treating cardiac and renal diseases compared to typical monotherapies. However, the protection mechanism of GXN is largely unknown.

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Article Synopsis
  • The estimated prevalence of anti-HCV in Taiwan's general population is 3.3%, with regional variations ranging from 0% to 65%, leading to around 623,323 individuals reactive to the virus.
  • Since 2018, Taiwan has made strides to eliminate hepatitis C, aiming to treat 80% of eligible patients by 2025 in line with the WHO's 2030 goals, supported by strong political commitment and reform in health insurance.
  • The National Hepatitis C Program focuses on harm reduction, improved screening awareness, and funding for care programs, emphasizing the need for expanded screening and diagnostics to reach the treatment target of 250,000 chronic hepatitis C patients by 2025.
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