Publications by authors named "Wen-Wen Ping"
J Cell Physiol
April 2019
Article Synopsis
- MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression by binding to messenger RNAs, and miR-133b has been found to be downregulated in various cancers, including bladder cancer.
- The study discovered that lower levels of miR-133b in bladder cancer tissues and cell lines are linked to worse patient survival, while transgelin 2 (TAGLN2) is overexpressed and associated with advanced cancer stages.
- Overexpressing miR-133b shows potential benefits, such as reducing cancer cell invasion and enhancing chemosensitivity, suggesting a new pathway involving miR-133b, TAGLN2, and the cell cycle that could be targeted for bladder cancer treatments.
Onco Targets Ther
November 2017
Article Synopsis
- Bladder cancer (BC) is a serious tumor of the urinary system with high mortality rates due to a lack of specific biomarkers for diagnosis and treatment.
- This study utilized weighted gene coexpression network analysis on miRNA data from BC patients to find key miRNAs associated with cancer progression and identified several functional pathways they influence.
- The research revealed novel prognostic miRNAs that could improve understanding of BC development, potentially serving as biomarkers for prognosis or targets for treatment strategies.
