Human epidermal growth factor receptor 2 expression level and combined positive score can evaluate efficacy of advanced gastric cancer.

Background: Although treatment options for gastric cancer (GC) continue to advance, the overall prognosis for patients with GC remains poor. At present, the predictors of treatment efficacy remain controversial except for high microsatellite instability.

Aim: To develop methods to identify groups of patients with GC who would benefit the most from receiving the combination of a programmed cell death protein 1 (PD-1) inhibitor and chemotherapy.

[AgBr] cluster-based 3D bromoargentate hybrid: crystal structure, optical/photoelectrical performance and theoretical study.

The self-assembly of cluster-based halide framework materials has been a matter of great interest but with great challenges. Herein, by exploiting hexamethylenetetramine (Hmta) with symmetry as a structural modifier, we successfully constructed and systematically characterized an unusual three-dimensional (3D) hybrid bromoargentate, namely K[NH][AgBr(Hmta)] (1), bearing a diamond-type [AgBr(Hmta)] anionic skeleton built up from adamantane-like units of inorganic [AgBr] clusters and organic Hmta ligands. UV-Vis diffuse reflectance analysis showed that the optical bandgap of the title compound was 2.

New group IIIA metal phosphate-oxalates containing dimethylammonium cations with proton conductivity.

Three new group IIIA metal phosphate-oxalate (MPO) compounds, namely [(CH)NH][M(HPO)(HPO)(CO)] (M = Al (1), Ga (2)) and [(CH)NH][In(HPO)(HPO)(CO)]·HO (3), have been synthesized. Their crystal structures feature an anionic layer with the topology net. In particular, 1 displays a proton conductivity () of 9.

Comparison of clinicopathological characteristics and survival outcomes between gallbladder mucinous adenocarcinoma and gallbladder adenocarcinoma: A propensity score-matched study.

Background: Gallbladder mucinous adenocarcinoma (GBMAC) is a rare subtype of gallbladder adenocarcinoma (GBAC), with limited knowledge of its survival outcomes from small case series and single-center retrospective analysis.

Aim: To compare the clinicopathological characteristics of GBMAC with typical GBAC and its prognostic factors to gain insights into this field.

Methods: This study was conducted using data from the Surveillance, Epidemiology, and End Results database, including cases of GBMAC and typical GBAC diagnosed from 2010 to 2017.

Recent advances in targeted therapy for pancreatic adenocarcinoma.

Pancreatic adenocarcinoma (PDAC) is a fatal disease with a 5-year survival rate of 8% and a median survival of 6 mo. In PDAC, several mutations in the genes are involved, with Kirsten rat sarcoma oncogene (90%), cyclin-dependent kinase inhibitor 2A (90%), and tumor suppressor 53 (75%-90%) being the most common. Mothers against decapentaplegic homolog 4 represents 50%.

Structural Evolution and Properties of Praseodymium Antimony Oxochlorides Based on a Chain-like Tertiary Building Unit.

Unveiling the structural evolution of single-crystalline compounds based on certain building units may help greatly in guiding the design of complex structures. Herein, a series of praseodymium antimony oxohalide crystals have been isolated under solvothermal conditions via adjusting the solvents used, that is, [HN(CHCH)][Fe(2,2'-bpy)][PrSbOCl]·EtOH () (2,2'-bpy = 2,2'-bipyridine), [HN(CHCH)][Fe(2,2'-bpy)][PrSbOCl)Cl]·N(CHCH)·2HO (), and (HO)[PrSbOCl(TEOA)]·2.5EtOH () (TEOA = mono-deprotonated triethanolamine anion).

Single-Crystal Superstructures via Hierarchical Assemblies of Giant Rubik's Cubes as Tertiary Building Units.

Intricate superstructures possess unusual structural features and promising applications. The preparation of superstructures with single-crystalline nature are conducive to understanding the structure-property relationship, however, remains an intriguing challenge. Herein we put forward a new hierarchical assembly strategy towards rational and precise construction of intricate single-crystal superstructures.

Rare Recurrent EWSR1-PLAGL1 Rearranged Intracranial Tumor With Biphasic Epithelioid Differentiation: One Case Report With Literature Review.

EWSR1-rearranged tumors encompass a rare and heterogeneous group of entities with features of the central nervous system (CNS) mesenchymal and primary glial/neuronal tumors. EWSR1-PLAGL1 gene fusion is a particularly rare form of rearrangement. We presented a recurrent intracranial EWSR1-PLAGL1 rearranged tumor and reviewed the relevant literature.

Long-term survival of a patient with pancreatic cancer and lung metastasis: A case report and review of literature.

Background: Pancreatic cancer (PC) is a leading cause of cancer-related death, given its poor prognosis and the limited benefits of traditional therapies. As tumors become more genetically disorganized as they progress, genetic mutations might become new markers for us to predict their behavior. Nowadays, many inhibitors can selectively target gene products as a form of targeted therapy, with some showing promise as treatment for various types of cancer.

[Development of critical nitrogen dilution curve based on leaf dry matter for maize under drip irrigation].

To provide a theoretical reference to nitrogen fertilizer management for maize and eco-enviromental protection in the irrigated area of Ningxia, we established the critical nitrogen concentration (N) dilution curve of maize under drip-irrigated condition. The nitrogen nutrition index (NNI) was deduced from the established N curve model, to diagnose feasibility of nitrogen nutrition. Six levels of nitrogen application rates including 0, 90, 180, 270, 360 and 450 kg·hm were conducted in field with maize variety 'Tianci 19'.

-derived outer membrane vesicles promote calcification of vascular smooth muscle cells through ERK1/2-RUNX2.

The outer membrane vesicle (OMV) derived from plays an essential role in causing inflammation which, in turn, plays an important part in the pathogenesis of cardiovascular diseases such as atherosclerosis and thromboembolism. However, the contribution of oral bacteria to vascular calcification is yet to be determined. Here, we evaluated the effect of OMV on vascular smooth muscle cell (VSMC) calcification both and .

Rho kinase mediates Porphyromonas gingivalis outer membrane vesicle-induced suppression of endothelial nitric oxide synthase through ERK1/2 and p38 MAPK.

Objective: To investigate the effect of Rho kinase (ROCK) on Porphyromonas gingivalis outer membrane vesicles (OMVs)-induced suppression of endothelial nitric oxide synthase (eNOS) and explore the potential mechanism.

Design: Firstly, we investigated the effect of OMVs on total eNOS expression and eNOS activity in Human Umbilical Vein Endothelial Cells (HUVECs) and if ROCK activation is involved. Furthermore, we estimated the effect of ROCK in regulating eNOS expression and the possible underlying mechanism in vitro.

Mapping brain injury with symmetrical-channels' EEG signal analysis--a pilot study.

A technique for detecting brain injury at the bedside has great clinical value, but conventional imaging techniques (such as computed tomography [CT] and magnetic resonance imaging) are impractical. In this study, a novel method-the symmetrical channel electroencephalogram (EEG) signal analysis-was developed for this purpose. The study population consisted of 45 traumatic brain injury patients and 10 healthy controls.

Modulation of frequency receptive field plasticity in rat auditory cortical neurons by electrical stimulation of medial prefrontal cortex.

Using conventional electrophysiological technique, we investigated the effects of stimulating the medial prefrontal cortex (mPFC) on plasticity of frequency receptive field (RF) in auditory cortical (AC) neurons in rats. When the mPFC was electrically stimulated, the RF plasticity of 51 (27.2%) neurons was not affected and that of 137 neurons (72.