Development and validation of a prediction model for ED using machine learning: according to NHANES 2001-2004.

Erectile Dysfunction (ED) is a form of sexual dysfunction in males that imposes significant health and financial burdens globally. Despite its high prevalence, diagnosing ED remains challenging due to the limitations of current diagnostic methods and patients' reluctance to seek medical help. Currently, some studies have used machine learning techniques for developing ED prediction models, but the performance and interpretability of existing models need to be further improved.

Post-marketing risk analysis of bendamustine: a real-world approach based on the FAERS database.

Bendamustine was approved for treating chronic lymphocytic leukemia and indolent B-cell non-Hodgkin lymphoma. Despite its therapeutic benefits, the long-term safety of bendamustine in a large population remains inadequately understood. This study evaluates the adverse events (AEs) associated with bendamustine, using a real-world pharmacovigilance database to support its clinical application.

Changes in the esophagogastric junction outflow obstruction manometric feature based on the Chicago Classification updates.

Background: The critical diagnostic criteria for esophagogastric junction outflow obstruction (EGJOO) were published in the latest Chicago Classification version 4.0 (CCv4.0).

Long-term effects of early stress due to earthquake exposure on depression symptoms in adulthood: a cross-sectional study.

Objective: This study aimed to investigate the long-term effects of early stress by Tangshan earthquake on symptoms of depression in adulthood.

Method: A total of 1534 volunteers born and raised in Tangshan were investigated; finally, 1328 subjects were enrolled in the study. They were divided into three groups according to their birth dates: infant exposure, prenatal exposure, and non-exposure.

Moxibustion regulates the polarization of macrophages through the IL-4/STAT6 pathway in rheumatoid arthritis.

Objective: To observe the effects of moxibustion on "Shenshu" and "Zusanli" on macrophage polarization and IL-4/STAT6 signaling pathway in rats with rheumatoid arthritis (RA). To further explore the possible anti-inflammatory mechanism of moxibustion in the treatment of RA.

Methods: The rats' right hind paws were injected with freund's complete adjuvant (FCA) to establish the model of RA.

Identification of breast cancer prognostic modules via differential module selection based on weighted gene Co-expression network analysis.

Breast cancer is a complex cancer which includes many different subtypes. Identifying prognostic modules, i.e.

Perinatal exposure to earthquake stress increases the risks of hypertension and diabetes in subsequent adult life: A cross-sectional study.

The objective of the current study was to determine whether exposure to earthquake stress during pregnancy and infancy impacted on the risk of chronic adult health problems. All subjects were divided into three groups: the infant exposure group, the fetus exposure group, and the non-exposure group. All subjects completed a standardized interview that included questions on demographic information, traumatic experiences during the earthquake, Anthropomorphic parameters such as body height, weight, and blood pressure were measured.

Effect of Moxibustion on Inflammatory Cytokines in Animals with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.

Background: This study aims to systematically evaluate the effect of moxibustion on the level of inflammatory cytokines in animal models with rheumatoid arthritis (RA) and to provide evidence for the clinical application of moxibustion to the treatment of RA and related basic researches.

Methods: The databases employed in this study include PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP), SinoMed, and Wanfang Data Information Site. The retrieval time was from the establishment of these databases to March 2020.

[Effects of moxibustion on serum cytokines in experimental animals with rheumatoid arthritis: a systematic review and meta-analysis].

Objective: To systematically review the effects of moxibustion on serum cytokines in experimental animals with rheumatoid arthritis.

Methods: PubMed, Embase, Web of Science, The Cochrane Library, CNKI, VIP, Wanfang Data, and CBM were searched for animal experiments on moxibustion intervention for rheumatoid arthritis. Related data were extracted, and RevMan 5.

Downregulating CREBBP inhibits proliferation and cell cycle progression and induces daunorubicin resistance in leukemia cells.

Low expression levels of CREB‑binding protein (CREBBP) have been demonstrated to be associated with high minimal residual disease at the end of induction therapy and adverse long‑term outcomes in pediatric patients with acute lymphoblastic leukemia (ALL). However, the effect of low CREBBP expression on the prognosis of ALL has not yet been investigated. In the present study, CREBBP was downregulated and overexpressed in ALL cell lines (Jurkat and Reh).

Acupuncture versus sham acupuncture for simple obesity: a systematic review and meta-analysis.

Obesity is a growing chronic health problem worldwide. Studies about acupuncture for obesity treatment are many. But there are some doubts about the effectiveness of acupuncture versus sham acupuncture in treating obesity due to its lack of medical evidence.

Acupuncture vs sham acupuncture for simple obesity: A protocol for systematic review and meta-analysis.

Background: Obesity is a growing chronic health problem worldwide. Studies about acupuncture for obesity treatment are many. But there are some doubts about the effectiveness of acupuncture vs sham acupuncture in treating obesity due to its lack of an evidence-based medical proof.

Isocyano(triphenylphosphoranylidene)acetates: Key to the One-Pot Synthesis of Oxazolo[4,5-]quinoline Derivatives via a Sequential Ugi/Wittig/aza-Wittig Cyclization Process.

A one-pot novel strategy is described for the construction of various oxazolo[4,5-]quinoline derivatives starting from the isocyano(triphenylphosphoranylidene)acetates, aldehydes, amines, and 2-azidobenzoic acids. The reactions generated the target products directly in moderate to good yields via a sequential Ugi/Wittig/aza-Wittig cyclization process. The salient features of the method are that all three groups of the multifunctional isocyanides were involved in the reaction with broad substituent scopes and mild reaction conditions, making the protocol a useful contribution to the synthesis of oxazolo[4,5-]quinoline heterocycles.

Synthesis of iminoisoindolinones via a cascade of the three-component Ugi reaction, palladium catalyzed isocyanide insertion, hydroxylation and an unexpected rearrangement reaction.

A robust ligand-free palladium-catalyzed cascade reaction for the synthesis of diversely substituted iminoisoindolinones has been developed. The cascade reaction involves isocyanide insertion into Ugi-3CR adducts, accompanied by unexpected hydroxylation and rearrangement.

[Effect of TBLR1-RARα Fusion Gene on Erythroid Differentiation of K562 Cells].

Objective: To explore the effects of TBLR1-RARα on the differentiation induction of leukemia cell line K562 cells into erythroid lineage and to investigate its related mechanisms.

Methods: Tet-Off inducible system was used to construct the conditional expression vector of TBLR1-RARα fusion gene by cloning the TBLR1-RARα fragment into lentivirus vector pLVX-Tight-Puro, the expression of TBLR1-RARα fusion gene was induced by doxycycline (Dox). Then, K562 cells were transfected with lentivirus pLVX-Tight-Puro-TBLR1-RARα-flag, and the expression of fusion proteins was verified by Western blot.

Baicalin Inhibits Lipopolysaccharide-Induced Inflammation Through Signaling NF-κB Pathway in HBE16 Airway Epithelial Cells.

Baicalin, a flavonoid monomer derived from Scutellaria baicalensis called Huangqin in mandarin, is the main active ingredient contributing to S. baicalensis' efficacy. It is known in China that baicalin has potential therapeutic effects on inflammatory diseases.

Lewis base catalyzed synthesis of multisubstituted 4-sulfonyl-1H-pyrazole involving a novel 1,3-sulfonyl shift.

A facile synthesis of highly substituted 4-sulfonyl-1H-pyrazoles from N-propargylic sulfonylhydrazone derivatives has been developed. Allenic sulfonamide formation and 1,3-sulfonyl shift were established to be the critical steps of this transformation.

[Prediction of respiratory motion based on nonparametric regression for real-time tumor-tracking radiotherapy].

Objective: It is necessary to compensate the system latencies in real-time tumor-tracking radiotherapy by prediction. However, due to the irregularities of respiratory motions, the results obtained with traditional methods were not acceptable. The purpose of this study is to evaluate the value of nonparametric regression model in respiratory motion prediction.

[Validation of an improved Demons deformable registration algorithm and its application in re-contouring in 4D-CT].

Objective: To validate the efficiency and accuracy of an improved Demons deformable registration algorithm and evaluate its application in contour recontouring in 4D-CT.

Methods: To increase the additional Demons force and reallocate the bilateral forces to accelerate convergent speed, we propose a novel energy function as the similarity measure, and utilize a BFGS method for optimization to avoid specifying the numbers of iteration. Mathematical transformed deformable CT images and home-made deformable phantom were used to validate the accuracy of the improved algorithm, and its effectiveness for contour recontouring was tested.

[Cone-beam CT reconstruction based on circular scan trajectory and ring artifact reduction].

The FDK algorithm is one of the most widely used algorithms for cone-beam CT reconstruction in circular trajectory due to its simplicity of implementation and computational efficiency. However, the images reconstructed by the FDK algorithm based on real projection data may be blurred without electronic correction and geometric calibration, and are often plagued by deleterious ring artifacts and shading artifacts. We compared the images reconstructed with and without detector correction based on computer experiment of the real biological object.

Comparative study of erythrocytes of polyploid hybrids from various fish subfamily crossings.

We have undertaken comparative studies of the number and phenotypes of erythrocytes in the peripheral blood of red crucian carp (RCC), blunt snout bream (BSB), and their hybrids, including triploids, tetraploids, and pentaploids. The results indicate that the mean nuclear volume of erythrocytes in peripheral blood increases regularly with increasing ploidy. Furthermore, many more mature erythrocytes have a dumbbell nucleus in the peripheral blood of polyploid hybrids compared with their diploid parents.

Application of photoluminescent CdS/PAMAM nanocomposites in fingerprint detection.

Uniform and well-dispersed photoluminescent semiconductor CdS (cadmium sulfide) QDs (quantum dots) were in situ prepared inside Generation 4.0-NH(2) PAMAM (polyamidoamine) dendrimers in methanol, methanol and water mixed solutions of volume ratio 1:9, respectively. The prepared solutions containing photoluminescent semiconductor CdS QDs were utilized for detection of cyanoacrylate ester fumed fingerprints on tinfoil.