Publications by authors named "Wen-Tao Zhong"
Article Synopsis
- Research shows significant differences between left-sided colon cancers (LCC) and right-sided colon cancers (RCC), particularly regarding the immune marker pan-immune-inflammation value (PIV) and its prognostic implications.
- A study with 1510 colon cancer patients found that while PIV levels were generally higher in RCC, after matching for other factors, there was no difference in PIV between the two groups.
- PIV is a useful predictor for disease-free survival (DFS) in LCC patients, where high PIV levels indicate worse DFS, but it does not show the same predictive ability in RCC patients.
Article Synopsis
- Immune checkpoint inhibitors (ICIs) are important in cancer treatment, but challenges like low response rates and differences in patient responses still need to be addressed.
- This study explores the major histocompatibility complex (MHC) as a key factor influencing ICI effectiveness by analyzing various types of RNA sequencing data from a large number of cells across multiple cancer types.
- The findings suggest that the MHC transcriptional feature (MHC.sig) can serve as a universal marker for anti-tumor immunity and may help identify new therapeutic targets, improving predictions for ICI responsiveness and guiding treatment strategies.
Article Synopsis
- * A case study features a 70-year-old man with pMMR rectal adenocarcinoma and multiple lymph node metastases, who underwent chemoradiotherapy followed by immunotherapy with Tislelizumab, resulting in a complete disappearance of the tumor.
- * This suggests that comprehensive chemoradiotherapy combined with immunotherapy may improve treatment outcomes for patients with advanced pMMR rectal cancer and preserved distant metastatic lymph nodes.
Implantation of nanofibrous silk scaffolds seeded with bone marrow stromal cells promotes spinal cord regeneration (6686 words).
Artif Cells Nanomed Biotechnol
December 2021
Spinal cord injury (SCI) is a common pathology often resulting in permanent loss of sensory, motor, and autonomic function. Numerous studies in which stem cells have been transplanted in biomaterial scaffolds into animals have demonstrated their considerable potential for recovery from SCI. In the present study, a three-dimensional porous silk fibroin (SF) scaffold with a mean pore size of approximately 383 μm and nanofibrous structure was fabricated, the silk scaffold enabling the enhanced attachment and proliferation of bone marrow stromal cells (BMSCs).
View Article and Find Full Text PDFExpression, purification, and bioactivity of GST-fused v-Src from a bacterial expression system.
J Zhejiang Univ Sci B
January 2006
v-Src is a non-receptor protein tyrosine kinase involved in many signal transduction pathways and closely related to the activation and development of cancers. We present here the expression, purification, and bioactivity of a GST (glutathione S-transferase)-fused v-Src from a bacterial expression system. Different culture conditions were examined in an isopropyl beta-D-thiogalactopyranoside (IPTG)-regulated expression, and the fused protein was purified using GSH (glutathione) affinity chromatography.
View Article and Find Full Text PDFCloning and GST-fused expression in E. coli of mouse beta-1,4-galactosyltransferase.
J Zhejiang Univ Sci
February 2004
Beta-1,4-galactosyltransferase (beta4Gal-T) (EC 2.4.1.
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