Glucose/Glutathione Co-triggered Tumor Hypoxia Relief and Chemodynamic Therapy to Enhance Photothermal Therapy in Bladder Cancer.

Photothermal therapy (PTT) is a potential treatment for cancer that makes use of near-infrared (NIR) laser irradiation and is expected to assist traditional anti-cancer drug therapies; however, the therapeutic efficacy of PTT is restricted by thermal resistance due to the overexpression of heat shock proteins and insufficient penetration depth of lasers. Thus, PTT needs to be combined with additional therapeutic methods to obtain the optimal therapeutic efficacy for cancer. Herein, a multifunctional therapeutic platform combining PTT with glucose-triggered chemodynamic therapy (CDT) and glutathione (GSH)-triggered hypoxia relief was developed via GOx@MBSA-PPy-MnO NPs (GOx for glucose oxidase, M for FeO, BSA for bovine serum albumin, and PPy for polypyrrole).

New Furanocembranoids from .

Three new furanocembranoids-briaviodiol F () and briaviotriols A () and B ()-along with a known analogue, briaviodiol A (), were obtained from a cultured-type octocoral . The structures of cembranoids ⁻ were elucidated by using spectroscopic methods. In vitro study demonstrated that compounds and exerted inhibition effects on inducible nitric oxide synthase (iNOS) release from RAW 264.

Neurological melioidosis (Burkholderia pseudomallei) in a chronic psychotic patient treated with antipsychotics: A case report.

Rationale: Neurological melioidosis, an extremely rare condition, is caused by the gram-negative bacterium Burkholderia pseudomallei. If treatment is suboptimal or delayed, this infection can produce diverse clinical symptoms and result in death.

Patient Concerns: A healthy 65-year-old female who had been treated with antipsychotic medication for neurotic depression for over 2 years presented with acute-onset fever, headache, lead-pipe rigidity of all limbs, and delirium.

Intrasinus thrombolysis by mechanical and urokinase for severe cerebral venous sinus thrombosis : a case report.

Purpose: Cerebral venous and sinus thrombosis (CVST) is a rare stroke disorder, which requires prompt recognition and appropriate intervention to prevent a devastating outcome. Intrasinus thrombolysis is an alternative and effective method to anticoagulant therapy for the treatment of CVST, but is rarely used in Taiwan.

Case Report: A 46-year-old man presented with a one-week history of intractable headache and progressive weakness of his right lower limb.

Panspinal epidural abscess concomitant with meningitis.

Panspinal epidural abscess is an extremely rare condition that can potentially lead to major permanent neurological deficits if treatment is delayed or suboptimal. Most patients with spinal epidural abscess have a short segment of vertebrae involved and classically present with fever, low back pain, and focal neurologic deficit. In severe cases, meningitis and septic shock may occur and lead to death.

Neurogenic stunned myocardium as a manifestation of encephalitis involving cerebellar tonsils.

Neurogenic stunned myocardium is defined as a myocardial injury or dysfunction after neurological insults. It is most commonly reported in patients with subarachnoid hemorrhage, and the presenting symptoms may mimic an acute myocardial infarction or myocarditis. In severe cases, cardiogenic shock and acute pulmonary edema may occur and lead to a devastating event.