Publications by authors named "Wen-Shuo Xu"
Article Synopsis
- The study investigates how exogenous glutathione (GSH) impacts ischemic stroke in rats, focusing on its therapeutic effects and the underlying mechanisms, particularly through quantitative proteomic analysis.
- Rats underwent a middle cerebral artery occlusion (MCAO) followed by treatment with GSH or L-dopa/carbidopa, with findings indicating that tyrosine metabolism and dopaminergic synapses are key pathways involved in stroke and GSH's therapeutic action.
- The treatment with L-dopa/carbidopa not only improved neurological function and reduced brain damage but also enhanced GSH levels by increasing its synthesis, suggesting potential combined therapeutic strategies for stroke recovery.
The aim of this study was to investigate the effect of hyaluronic acid (HA) on the expression of osteopontin (OPN) and CD44 mRNA of fibroblast-like synoviocytes (FLS) in the patients with osteoarthritis (OA) of the knee. FLS were obtained from the knees of 10 patients with OA. Real-time quantitative polymerase chain reaction (Q-PCR) was used to assess the expression of the OPN mRNA and CD44 mRNA.
View Article and Find Full Text PDFBone turnover in passive smoking female rat: relationships to change in bone mineral density.
BMC Musculoskelet Disord
June 2011
Background: Many studies have identified smoking as a risk factor for osteoporosis, but it is unclear whether passive smoking has an effect on bone mineral density and bone turnover and if such an effect could cause osteoporosis.The purpose of the study was to investigate the effect of passive smoking on bone mineral density (BMD) and bone turnover and the relationship between BMD and bone turnover in female rat.
Methods: Forty-eight female Wistar rats were randomized into six groups: 2-month, 3-month,4-month smoke-exposed rats and their controls.