[Effect of metformin on insulin resistance during catch-up growth in mice with fetal growth restriction].

Objective: To study the efficacy of metformin intervention on insulin resistance during catch-up growth in mice with fetal growth restriction (FGR).

Methods: Mouse models of FGR were established by low protein diet feeding of the pregnant mice. Both the newborn female mice with FGR and normal control (NC) mice were randomized for feeding with a standard diet (SF) or a high-fat diet (HF) after weaning and treatment with gavage of either metformin or normal saline.

Endocrine dysfunction and follow-up outcomes in patients with pituitary abscess.

Objective: Endocrine dysfunction caused by pituitary abscess (PA) and its outcomes have not been fully studied. This study aims to investigate endocrine dysfunction and outcomes in patients with PA.

Methods: Eight patients (3 males and 5 females) with PA were identified for collecting clinical, hormone, and therapeutic data before and after long-term follow-up lasting 12 to 116 months (median, 25 months) since the first hospitalization, which was regarded as the baseline time.

Complications of laparoscopic cholecystectomy and its prevention: a review and experience of 400 cases.

In the present era laparoscopic cholecystectomy (LC) has become the gold standard treatment of choice for gallstone disease. This technique has made a new revolution in minimal invasive surgery, but also the spectrum of complications has changed. In this paper we shared our personal experience of LC in 400 hundred cases from January 2007 to December 2010, its complications and prevention.

Insulin resistance and carotid atherosclerosis in 221 patients with potential hyperglycemia.

Objective: To investigate the relationship between insulin resistance and carotid atherosclerosis in patients with potential hyperglycemia.

Methods: A total of 221 patients were recruited among those with potential hyperglycemia. All participants underwent physical examination, medical history interview, and 75 g oral glucose tolerance test.

[Lymphocytic hypophysitis: a report of 3 cases].

Objective: Lymphocytic hypophysitis is a rare inflammatory lesion of pituitary gland. To enhance the knowledge of lymphocytic hypophysitis, herein we reported 3 cases of lymphocytic hypophysitis and reviewed the literature.

Methods: The clinical data of 3 patients diagnosed as having lymphocytic hypophysitis were analysed.

Proliferative response of human prostate cancer cell to hormone inhibited by androgen receptor antisense RNA.

Background: The failure of endocrine treatment for advanced prostate cancer might be related to aberrant activation of androgen receptor (AR). Prostate cancer cell line LNCaP contains AR that can be activated by androgen, estrogen and progesterone. This study was set to investigate the effects of antisense AR RNA on growth of LNCaP cultured in medium containing varied concentrations of R1881, 17beta-estradiol, and progesterone, respectively.

[Relationship between plasma glucose level and insulin secretion in type 2 diabetic patients].

Objective: To investigate the association between insulin secretion and plasma glucose levels, and the potential effect of plasma glucose concentration on insulin secretion stimulated by glucose in patients with type 2 diabetes.

Methods: A total of 124 patients with type 2 diabetes were enrolled to undergo 75 g oral glucose tolerance test (OGTT) and insulin releasing test (IRT), 24 h after discontinuation of oral hypoglycemic agent or insulin injection. The plasma levels of glucose and insulin, effects of fasting and postprandial plasma levels of glucose and insulin, the time of maximal glucose value in OGTT, the ratio of maximal to basal glucose levels (M/Bg) were determined to assess their effects on the basal and stimulated insulin secretion.