Publications by authors named "Wen-Rui Zheng"
Article Synopsis
- Environmental pollution, specifically heavy metals, may negatively impact the prognosis of advanced high-grade serous ovarian cancer (HGSOC), but current evidence is limited.
- A study involving 159 deceased HGSOC patients and 159 matched living patients analyzed urinary levels of five heavy metals—arsenic, cadmium, chromium, mercury, and lead—using statistical models to determine associations with overall survival (OS).
- The results showed significant links between high levels of arsenic, cadmium, mercury, and lead in urine and poorer OS, with lead being the most influential in negatively affecting survival, indicating a need for further research.
Article Synopsis
- Meta-analyses have shown mixed results regarding the relationship between whole blood cell count-derived indexes (NLR, PLR, LMR) and cancer prognosis, highlighting the need for a clearer understanding of the evidence quality.* ! -
- The review analyzed 694 associations from 224 articles, revealing that 97.8% of these studies were rated as moderate to high quality based on AMSTAR criteria.* ! -
- Although there were four associations with strong evidence, many others were only suggestive, indicating a need for further research to clarify these relationships and determine causality.* !
Article Synopsis
- Research shows that per- and polyfluoroalkyl substances (PFASs) have possible links to various health issues, but more studies are needed for conclusive findings.
- A systematic review examined 157 meta-analyses assessing PFAS health impacts, indicating moderate-to-high quality results for most studies, particularly highlighting significant associations with low birth weight and immune response.
- While strong evidence connects some PFASs to specific health outcomes, many associations still lack certainty, with a substantial number of potential health effects needing further investigation.
A highly diastereoselective domino reaction of 2,6-diaminopyrimidine-4-one with structurally diverse aryl aldehydes and various barbituric acids in water under microwave irradiation is described. The products are 6-spiro-substituted pyrido[2,3-d]pyrimidines with high diastereoselectivities (up to 99: 1) in which the major diastereomer bears a cis relationship between substituents at the 5- and 7-positions. Furthermore, the mechanism for diastereoselectivity was confirmed by DFT (B3LYP) calculations.
View Article and Find Full Text PDFG3//BMK and Its Application to Calculation of Bond Dissociation Enthalpies.
J Chem Theory Comput
August 2008
On the basis of systematic examinations it was found that the BMK functional significantly outperformed the other popular density functional theory methods including B3LYP, B3P86, KMLYP, MPW1P86, O3LYP, and X3LYP for the calculation of bond dissociation enthalpies (BDEs). However, it was also found that even the BMK functional might dramatically fail in predicting the BDEs of some chemical bonds. To solve this problem, a new composite ab initio method named G3//BMK was developed by combining the strengths of both the G3 theory and BMK.
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