Luspatercept enhances hemoglobin levels in a Chinese boy with congenital sideroblastic anemia: A case report.

Background: Congenital sideroblastic anemia (CSA) is a rare and heterogeneous group of genetic disorders. Conventional treatment include pyridoxine (vitamin B6) and allogeneic hematopoietic stem cell transplantation (allo-HSCT), and can alleviate anemia in the majority of cases. Nevertheless, some CSA cases remain unresponsive to pyridoxine or are unable to undergo allo-HSCT.

[Relationship between Changes of Lymphocyte Subsets and Early Hematologic Response in Immunosuppressive Therapy of Severe Aplastic Anemia Patients].

Objective: To explore the relationship between the change of lymphocyte subsets before and after immunosuppressive therapy (IST) with disease severity of severe aplastic anemia (SAA) and hematologic response to IST.

Methods: The clinical data of 94 patients with SAA/VSAA treated by r-ATG and CsA in our hospital from December 2009 to October 2011 was analyzed retrospectively. Among them, 26 patients who had sequential data of lymphocyte subsets and cytokines before and after treatment were enrolled.

Next generation sequencing reveals co-existence of hereditary spherocytosis and Dubin-Johnson syndrome in a Chinese gril: A case report.

Background: Hereditary spherocytosis (HS) is a hereditary disease of hemolytic anemia that occurs due to the erythrocyte membrane defects. Dubin-Johnson syndrome (DJS), which commonly results in jaundice, is a benign hereditary disorder of bilirubin clearance that occurs only rarely. The co-occurrence of HS and DJS is extremely rare.

[Predicting early response to immunosuppressive therapy in severe aplastic anemia by soluble transferrin receptor assay].

Objective: To evaluate the value of serum soluble transferrin receptor (sTfR) concentration in predicting early response to immunosuppressive therapy (IST) in severe aplastic anemia (SAA).

Methods: Clinical data and hematologic responses of 140 SAA patients treated with rabbit antithymocyte globulin (rATG) combination with cyclosporine in our hospital were retrospectively analyzed. Correlation of pre-IST baseline of sTfR and IST responses was statistically analyzed and receiver operating characteristic (ROC) curve was used to estimate the sensitivity and specificity of sTfR in prediction of early responses.

[Adaptive optimized technologies for ecological sanitation and their complex ecological benefits].

Aiming at the ecological characters of the cities in central and west China, several ecological sanitary (ecosan) technologies with different adaptability were integrated, and five adaptive optimized technologies were established. The environmental effects, resources recyclable potential, economic benefits, management difficulties, and public acceptance of each of the technologies were studied, with the possible complex eco-benefits of the technical improvement assessed. The results showed that decentralized ecosan technologies had the advantages of conserving water, recycling nutrients and saving cost, but also had the problems in management and public acceptance.

[Application of inverse distance weighted interpolation method in contaminated site assessment].

There are many difficulties in ascertaining the area that needs to be remedied in contaminated site. This paper integrated the experts' judgments with grids as the sampling strategy in an abandoned pesticide plant in northern China, and applied a geostatistical method, inverse distance weighted interpolation (IDW), to simulate the pollutants- and risk spatial distribution. Based on soil environmental benchmark, two scenarios were designed for ascertaining the polluted area.

[Ecological risk assessment and its research progress].

Ecological risk is a hotspot in the present environmental management study, which mainly focuses on the chemical, physical, and biological stressors that may damage ecosystem or its components. Ecological risk assessment (ERA) has a great significance for making scientific environmental management strategies. In order to lessen the damage of ecosystem or its parts, and to manage the ecosystem effectively, it is necessary to predict the probability the adverse ecological effects would occur and the consequences.