Publications by authors named "Wen-Rui Hou"
[Study on effect of total coumarins from Urtica dentata on dextran sulfate sodium-induced colitis in mice].
Zhongguo Zhong Yao Za Zhi
November 2012
Article Synopsis
- The study investigates the impact of total coumarins from Urtica dentata on colitis induced by dextran sulfate sodium in mice.
- Mice treated with total coumarins experienced less weight loss, lower levels of inflammation markers IL-6 and IFN-gamma, and increased anti-inflammatory cytokines IL-10 and TGF-beta1.
- The findings suggest that total coumarins have an anti-inflammatory effect, improving colitis symptoms by modulating inflammatory protein expressions and cytokine levels.
The aim of this study is to investigate the therapeutic effect of RegIII-proinsulin-pBudCE4.1 plasmid on streptozotocin (STZ)-induced type 1 diabetes mellitus and its underlying mechanisms. The model of type 1 diabetes mellitus was established by intraperitoneal injections of STZ (40 mg kg(-1)) to Balb/c mice for five consecutive days.
View Article and Find Full Text PDFType 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by inflammation of pancreatic islets and destruction of β cells. Up to now, there is still no cure for this devastating disease and alternative approach should be developed. To explore a novel gene therapy strategy combining immunotherapy and β cell regeneration, we constructed a non-viral plasmid encoding proinsulin (PI) and pancreatic regenerating (Reg) III protein (pReg/PI).
View Article and Find Full Text PDFA novel biscoumarin, 6,6',7,7'-tetramethoxyl-8,8'-biscoumarin (1), was isolated from the ethyl acetate extract of Urtica dentata Hand, together with five known compounds named as 7,7'-dihydroxy-6,6'-dimethoxy-8,8'-biscoumarin (2), 7,7'-dimethoxy-6,6'-biscoumarin (3), scoparone (4), vanillic acid (5), and daucosterol (6). Structures of the isolated compounds were elucidated on the basis of spectroscopic analysis including 2D NMR experiments. Compounds 1 and 2 were confirmed to be a rare carbon-carbon linked symmetrical biscoumarin.
View Article and Find Full Text PDFAim Of The Study: To investigate the immunosuppressive effects of HPLC qualitied ethyl acetate extract (EAE) from Urtica dentate Hand on skin allograft rejection in a murine model.
Materials And Methods: Allo-skin transplantation model was established by placing skin allograft of C57BL/6 mice in the wound bed which was on the back of Balb/c mice. We used FACS to study the effects of EAE on dendritic cells (DCs) maturation and CD4(+)CD25(+)T regulatory cells (Tregs) differentiation.