Publications by authors named "Wen-Qing Geng"
Article Synopsis
- Men who have sex with men (MSM) with experience in oral PrEP are generally willing to adopt long-acting injectable PrEP (LAI-PrEP), with 77.8% expressing interest in free LAI-PrEP.
- Factors influencing this willingness include a higher number of sexual partners, male partners with unknown HIV statuses, and recreational drug use, while those who used event-driven oral PrEP and had poor adherence to oral PrEP were less inclined to switch to LAI-PrEP.
- Findings suggest that LAI-PrEP could enhance PrEP coverage, but special attention is needed for those struggling with adherence to existing oral PrEP methods.
Prevention and control of HIV/AIDS in China: lessons from the past three decades.
Chin Med J (Engl)
November 2021
In the past 37 years, human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) has undergone various major transmission routes in China, with the world most complex co-circulating HIV-1 subtypes, even the prevalence is still low. In response to the first epidemic outbreak of HIV in injecting drug users and the second one by illegal commercial blood collection, China issued the Anti-Drug Law and launched the Blood Donation Act and nationwide nucleic acid testing, which has avoided 98,232 to 211,200 estimated infections and almost ended the blood product-related infection. China has been providing free antiretroviral therapy (ART) since 2003, which covered >80% of the identified patients and achieved a viral suppression rate of 91%.
View Article and Find Full Text PDFObjectives: Peripheral blood lymphocyte subsets are important parameters for monitoring immune status; however, lymphocyte subset detection is time-consuming and error-prone. This study aimed to explore a highly efficient and clinically useful autoverification system for lymphocyte subset assays performed on the flow cytometry platform.
Methods: A total of 94,402 lymphocyte subset test results were collected.
Article Synopsis
- This study investigates the preference between daily and on-demand PrEP (pre-exposure prophylaxis) among men who have sex with men (MSM) in developing countries, specifically in major cities of China.
- Out of 1,933 MSM participants, 57.1% preferred on-demand PrEP, while 42.9% leaned towards daily PrEP; factors like marital status and perceived HIV risk influenced these preferences.
- The study found that individuals currently in a relationship with a female partner had a lower preference for daily PrEP, while those with more male sexual partners and a higher perception of HIV risk preferred daily PrEP.
Background: Human immunodeficiency virus (HIV) prevalence among student men who have sex with men (MSM) in college is more than 5.0% and keeps on increasing in China. This study aims to clarify the proportion of HIV recent infection, its propeller and the source among college student MSM.
View Article and Find Full Text PDFBackground: Biomedical interventions such as antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) are highly effective for prevention of human immunodeficiency virus (HIV) infection. However, China has not released national PrEP guidelines, and HIV incidence among men who have sex with men (MSM) is unchanged despite substantial scale-up of ART. We evaluated reductions in HIV transmission that may be achieved through early initiation of ART plus partners' PrEP.
View Article and Find Full Text PDFIntimate partner violence (IPV) and HIV are highly prevalent worldwide among MSM. However, the association between IPV and HIV seroconversion is virtually unknown. This 12-month prospective cohort study was conducted among MSM in Shenyang, China to explore the causality between IPV and the incidence of HIV.
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- The study redefines migration status based on how long men who have sex with men (MSM) have lived in their current city, instead of just residency registration, to explore HIV infection risks.
- Conducted in seven Chinese cities, the research indicated that migrant MSM, particularly those residing for less than a year, exhibited lower HIV knowledge and higher-risk sexual behaviors compared to transitional (longer-resident) and local MSM.
- Findings revealed that migrant MSM had a higher prevalence of HIV compared to local MSM, with specific behaviors like male sex work and drug use linked to increased HIV risk, suggesting a need for targeted prevention efforts.
The use of poppers is highly prevalent in MSM, but little is known about the association between their use and HIV incidence in China. A prospective cohort study was conducted from 2011 to 2013 in MSM in Shenyang. 475(79.
View Article and Find Full Text PDFObjective: To estimate the medicine-taking compliance (MTC) level, explore its facilitators and barriers, and quantify the association between MTC level and pre-exposure prophylaxis (PrEP) protective efficacy in individuals at risk of acquiring HIV being administered oral PrEP.
Design: Meta-analysis.
Data Sources: We searched PubMed, Cochrane and Embase databases for published randomized controlled trials (RCTs) pertaining to MTC of oral PrEP for HIV prevention up to 16 January 2017.
HIV testing is the first step to the fulfillment of Treat as Prevention (TasP) and reaching the 90-90-90 goal in HIV control. However, there are still a large number of Men who have Sex with Men (MSM) have never been tested for HIV before, and little is known about the HIV incidence and care linkage among this population. A Mixed method was used to recruit MSM who had never tested for HIV before from January 2012 to December 2014 in Shenyang, China.
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- HIV prevalence is rising among Chinese men who have sex with men (MSM), particularly among those seeking partners online, with Internet-based MSM significantly increasing from 43.3% to 61.5% between 2009 and 2014.
- The study showed that HIV rates for Internet-based MSM (IBM) rose from 5.7% to 20.7%, compared to 7.0% to 14.7% for non-Internet-based MSM (NIBM), indicating IBM faces higher infection rates.
- Risk factors contributing to higher HIV prevalence in IBM included being a migrant MSM and infrequently using condoms during casual encounters, suggesting a need for tailored interventions for this demographic.
Background: Delayed or inappropriate treatment for sexually transmitted diseases (STDs) increases the risk of HIV acquisition and may cause other harmful outcomes. However, studies on STD treatment-seeking behaviour and correlated factors in men who have sex with men (MSM) are scarce. This information is crucial for the promotion of STD treatment-seeking behaviour and reduction of HIV transmission among Chinese MSM.
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- Men who have sex with men (MSM) are at heightened risk for HIV and STIs, particularly those engaged in commercial sex in China.
- A study surveyed 3,717 MSM across six cities, revealing significant prevalence rates: 11.1% for HIV, 8.8% for syphilis, and 12.1% for HSV-2, with MSM selling sex showing the highest infection rates, although not statistically significant.
- The findings indicate that MSM selling sex are likely to engage in risky behaviors, such as unprotected sex and drug use, highlighting the need for targeted health interventions for this vulnerable group.
Article Synopsis
- The study focused on the prevalence and risk factors for HSV-2 and syphilis infections among HIV-positive men who have sex with men (MSM) in China.
- The research involved examining 545 MSM in Shenyang from 2009 to 2014, revealing that 48.6% had HSV-2 mono-infection, 34.3% had syphilis mono-infection, and 22.9% had both infections simultaneously.
- Key determinants for co-infection included older age, having regular female partners, and the age of first MSM experience, highlighting the urgent need for targeted detection and treatment initiatives.
Background: Recent upsurge of new HIV infections among men who have sex with men (MSM) is a major concern in China. Paucity of national-level information regarding the burden and predictors of this progressive epidemic of new infections called for a multi-centric, timely and comprehensive investigation.
Methods: Mixed methods were used to recruit MSM from seven cities in China between 2012 and 2013.
Objectives: To understand the current risk of HIV infection and transmission and further elucidate the underlying risk factors among men who have sex with men and women (MSMW) in China.
Methods: Following PRISMA guidelines, we conducted a systematic review and meta-analysis of searching through Chinese and English available literature databases between January 2000 and June 2014 to identify articles.
Results: Thirty-six articles (including 19,730 MSMW and 53,536 MSMO) met the selection criteria and the aggregated results found that MSMW have significantly higher HIV prevalence than MSMO (6.
Background: Recreational drug use (RDU) may result in sexual disinhibition and higher risk for HIV and other sexually transmitted infections (STIs) among men who have sex with men (MSM) in China. We assessed whether RDU was associated with HIV, syphilis, and herpes simplex virus type 2 (HSV-2) within the context of multiple sexual partnerships and unprotected sex.
Methods: We conducted a cross-sectional study among sexually-active MSM in six Chinese cities (Kunming, Jinan, Changsha, Zhengzhou, Nanjing, and Shanghai) in 2012-2013.
Article Synopsis
- The study investigates short-term mortality rates among critically ill HIV-1 patients in China, highlighting important clinical and laboratory factors that contribute to their increased risk of death.
- Among the 141 patients analyzed, common symptoms included fever and weight loss, with significant laboratory abnormalities like low CD4+ counts and hypoalbuminemia being prevalent among those who died.
- Key independent risk factors for mortality identified were active tuberculosis, hyponatremia, and being classified as clinical stage 4 by the World Health Organization.
Article Synopsis
- A study in Shenyang, China, found that 23.2% of 625 surveyed MSM used recreational drugs, with alkyl nitrites being the most common.
- The prevalence of HIV was 9.6% and syphilis was 10.4%, with drug use linked to factors like being under 25, single status, and finding partners online.
- Recreational drug use was identified as increasing the risk of HIV infection significantly, highlighting the need for targeted prevention programs.
The identification of broadly cross-reactive neutralizing (BCN) antibodies is essential for the development of a more universally effective vaccine for human immunodeficiency virus (HIV). In this study, CRF07_BC serum was analyzed for cross-clade antibody reactivity and neutralization. A total of 117 HIV-1 sera (CRF07_BC) were screened for their capacity to neutralize three primary HIV-1 isolates.
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- TLR7 and TLR8 are crucial for recognizing viral RNA and could influence HIV infection and its progression.
- A study involving 81 individuals from China assessed how TLR7/8 expression and signaling in monocytes varied between HIV-infected and uninfected subjects.
- Results showed that TLR7/8 mRNA levels decreased with advancing disease, and stimulating these receptors with R-848 not only reduced HIV replication in cultured monocytes but also suggested potential for new treatments to delay HIV disease progression.