Pharmacologic Effect of Miao Medicine Maxim. on Collagen-Induced Arthritis in Rats.

Objectives: To study the pharmacologic effect and mechanism of action of Miao medicine Maxim. (ISM) in treating rheumatoid arthritis.

Methods: Sixty rats were randomly divided to six groups: normal control (normal), collagen-induced arthritis (CIA) model (model), CIA + tripterygium glycosides (TG), CIA + ISM high dose oral (ISM-H), CIA + ISM low-dose oral (ISM-L), and CIA + ISM topical application (ISM-T).