Publications by authors named "Wen-Qin Fan"
Lycium barbarum (LB) is a famous traditional Chinese medicinal plant as well as food supplement possessing various pharmacological functions such as anti-aging and antioxidant effects. The Parkinson's disease (PD)-related kinase Pink1 plays vital role in maintaining the neuron cell homeostasis, having been recognized as a potential target for the development of anti-PD drugs. In this work, the neuroprotective effects of methanol extract of LB fruit (LBFE) were investigated using a Drosophila PD model (PINK1) and a human neuroblastoma SH-SY5Y cell line.
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- The rhizome tuber known as 'Bai Fuzi' in China has been used in traditional medicine for treating neurological diseases, especially Parkinson's disease (PD).
- Researchers isolated nineteen compounds from Bai Fuzi, among which four (berberine, nicotinamide, rutin, and 5-caffeoylquinic acid) were reported for the first time.
- Six of these compounds showed moderate inhibition of the MAO-B enzyme, and two exhibited significant protective effects in a PD cell model, indicating Bai Fuzi's potential as an anti-PD herb in traditional Chinese medicine.
Introduction: As a famous traditional Chinese medicine, roots of Platycodon grandiflorus (Jacq.) A.DC.
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