Publications by authors named "Wen-Qian Zhong"
Article Synopsis
- Scientists are trying to find out how drugs work with proteins in our body, but traditional methods are expensive and take a lot of time.
- They created a new method using a computer to better predict how drugs interact with proteins, achieving a high accuracy of 92.53% in their results.
- This method helped identify 2272 possible drug-protein interactions that could lead to treatments for diseases like Torg-Winchester syndrome and rhabdomyosarcoma.
Identifying potential drug target proteins is a crucial step in the process of drug discovery and plays a key role in the study of the molecular mechanisms of disease. Based on the fact that the majority of proteins exert their functions through interacting with each other, we propose a method to recognize target proteins by using the human protein-protein interaction network and graph theory. In the network, vertexes and edges are weighted by using the confidence scores of interactions and descriptors of protein primary structure, respectively.
View Article and Find Full Text PDF