Prognostic significance of soluble CD25 in patients with sepsis: a prospective observational study.

Objectives: The diagnosis of sepsis is challenging, the need for sensitive and specific diagnostic and prognostic biomarkers has not been met. Soluble CD25 (sCD25) is a readily available biomarker reported to represent the severity of the disease. This study aimed to assess the association between sCD25 and mortality in patients with sepsis.

[Effect of Acupuncture Stimulation of Different Acupoint Combinations on Sleep and Expression of Circadian and Bmal 1 Genes in Hypothalamus of Insomnia Rats].

Objective: To observe the effect of manual acupuncture stimulation (MAS) of "Baihui"(GV 20)-"Shenmen"(HT 7)or GV 20-"Sanyinjiao"(SP 6) on sleep and expression of circadian rhythm genes ( and Bmal 1) in the hypothalamus in insomnia rats, so as to select a better acupoint group for insomnia.

Methods: A total of 53 SD rats were randomly divided into normal control (=12),insomnia model (=8), GV 20-HT 7(=12), GV 20-SP 6(=11),and GV 20-non-acupoint (=10) groups. The insomnia model was established by intraperitoneal injection of p-chlorophenylalanine (PCPA,500 mg/kg,100 mg/mL) once daily for 2 days.