Publications by authors named "Wen-Min Pi"
Podophyllotoxin's undifferentiated cytotoxicity and poor selectivity limit its clinical application. To improve above disadvantages, conjugation of bile acids with podophyllotoxin could improve cell line selectivity of liver cancer to achieve clinical translation further. Enlightened by the bile acids' moiety magic characters, thirty podophyllotoxin-linked bile acid derivatives had been designed and synthesized.
View Article and Find Full Text PDFArticle Synopsis
- A combination of network pharmacology and mass spectrometry was employed to analyze the antioxidant properties of Hippophae tibetana, identifying key quality markers (Q-markers) responsible for its antioxidant effects.
- The study used ultra-high performance liquid chromatography to separate the chemical components of H. tibetana, revealing 51 different constituents, including various flavonoids, terpenoids, and alkaloids.
- The antioxidant efficacy of different extract fractions was evaluated, finding that flavonoids like quercetin, luteolin, and kaempferol significantly influence the antioxidant activity, primarily through the PI3 K-Akt and FoxO signaling pathways.