Bavachin Protects Human Aortic Smooth Muscle Cells Against -Glycerophosphate-Mediated Vascular Calcification and Apoptosis Activation of mTOR-Dependent Autophagy and Suppression of -Catenin Signaling.

Vascular calcification is a major complication of cardiovascular disease and chronic renal failure. Autophagy help to maintain a stable internal and external environment that is important for modulating arteriosclerosis, but its pathogenic mechanism is far from clear. Here, we aimed to identify the bioactive compounds from traditional Chinese medicines (TCM) that exhibit an anti-arteriosclerosis effect.